Manufacturing process and formula for relieving nervous system symptoms from Mucuna pruriens and banana blossom.

Abstract

------13 / 11 / 2560------(OCR) Page 1 of 1 Summary of the invention. Manufacturing process and formula for products to relieve nervous system symptoms from Mucuna pruriens and banana blossom. In the form of standard film-coated tablets containing 10-15 mg of Mucuna pruriens extract. The percentage by weight, according to this pharmaceutical manufacturing process, results in a product with the following properties: Relieving neurological symptoms caused by Parkinson's disease, such as stiffness, rigidity, and slow movement. ------------ Updated 15 / 03 / 2017 Manufacturing process and formula for products to relieve nervous system symptoms from Mucuna pruriens and banana blossom. In the form of standard film-coated tablets containing 10-15 mg of Mucuna pruriens extract. The percentage by weight, according to this pharmaceutical manufacturing process, results in a product with the following properties: Relieving neurological symptoms caused by Parkinson's disease, such as tremors, rigidity, and slow movement. --------------------- Manufacturing process and formula for products to relieve nervous system symptoms from Mucuna pruriens and banana blossom. In the form of standard film-coated tablets containing 10-15 mg of Mucuna pruriens extract. The percentage by weight, according to this pharmaceutical manufacturing process, results in a product with the following properties: Relieving neurological symptoms caused by Parkinson's disease, such as tremors, rigidity, and slow movement.

Claims

------13 / 11 / 2017------(OCR) Page 1 of 2 pages Claims 1. A formula for a film-coated tablet formulation containing Mucuna pruriens extract (10-15% by weight), corn starch (1-5%), lactose (55-70%), talcum (1-3%), magnesium stearate (1-3%), PVPK-30 (5-10%), and gelatin (1-5%) by weight, for relieving nervous system symptoms.

2. The manufacturing process for the Mucuna pruriens extract product, which involves the following steps: Step a.The preparation of core tablets is as follows: Mix 55-70% by weight of lactose, 1-5% by weight of corn starch, and 10% by weight of PVPK-305. Gradually add 10-15% by weight of Mucuna pruriens extract and mix thoroughly. Dissolve 1-5% by weight of gelatin in 8-9% volume / weight of the formula water to help wet the powder. Sieve the wet granules and dry them at 50°C. Sieve the dried granules again, then mix with 1-3% by weight of talcum and 1-3% by weight of magnesium stearate, and then compress into tablets. B. The two-layer film coating of core tablets is as follows: The formula for the first layer film coating of the core tablet is: Methocel E5 (formula) 1-5% by weight, Methocel E15 (formula) 1-5% by weight, Titanium dioxide 5-10% by weight, Talcum 1-5% by weight, Polyethylene glycol 6000 1-5% by weight, Antifoam (10% solution) 0.1-1% by weight, Water 80-85% by weight. (Page 2 of 2) Mixture 1: Mix Methocel E5, Methocel E15, Talcum, and Titanium dioxide together according to the formula. Mixture 2: ...Dissolve polyethylene glycol 6000 and antifoam in water according to the formula. Pour mixture 1 into mixture 2 and grind both mixtures until a smooth, homogeneous mixture is obtained. Then use it to coat the tablets. The second film coating formula for core tablets consists of: Methocel E5 (formula) 1-5% by weight, Methocel E15 (formula) 1-5% by weight, Titanium dioxide 5-10% by weight, Talcum 1-5% by weight, Brilliant blue (Aluminium Lake) 1-3% by weight, Tartrazine (Aluminium Lake) 0.1-2% by weight, and polyethylene glycol 6000. 1-5% by weight antifoam (Antifoam-10% solution) 0.1-1% by weight water 80-85% by weight. Mixture 1: Mix Methocell E5, Methocell E15, Talgam, Titanium Dioxide, Brilliant Blue, and Tartrazine according to the formula. Mixture 2: Dissolve Polyethylene Glycol 6000 and antifoam according to the formula in water. Pour Mixture 1 into Mixture 2. Grind both mixtures until a smooth, homogeneous mixture is obtained. Then use it to coat the tablets. ------------Revised 15 / 03 / 2017.The manufacturing process and formulation of the film-coated tablet formulation of Mucuna pruriens (V.C. pruriens) for relieving nervous system symptoms are as follows: a. The pharmaceutical formulation for relieving nervous system symptoms from Mucuna pruriens (V.C. pruriens) in film-coated tablet form consists of Mucuna pruriens extract 10-15% by weight, corn starch 1-5% by weight, lactose 55-70% by weight, talcum 1-3% by weight, magnesium stearate 1-3% by weight, PVPK-30 5-10% by weight, and gelatin 1-5% by weight. b. ... (The rest of the text appears to be cut off.)The manufacturing process for the nutritional pharmaceutical product for relieving neurological symptoms from Mucuna pruriens and Musa acuminata is as follows: Step 1: Preparation of core tablets. Prepare granules using the "wet granulation" method. Mix 55-70% by weight of lactose, 1-5% by weight of corn starch, and 10% by weight of PV-PK-305-10. Gradually add 10-15% by weight of Mucuna pruriens extract and mix thoroughly. Dissolve 1-5% by weight of gelatin in 8-9% volume / weight of water (the formula's volume / weight ratio) to help wet the powder. Sieve the mixture and dry the wet granules at 50°C. Sieve the dried granules again, then mix with 1-3% by weight of talcum and 1-3% by weight of magnesium stearate, and press into tablets. Step 2: Two-layer film coating of core tablets. The first layer film coating formula for Methocel E5 core tablets is as follows: (MethocelE5 formula). 1-5% by weight Methocel E15 (formula), 1-5% by weight Titanium dioxide, 5-10% by weight Talcum, 1-5% by weight Polyethylene glycol 6000, 1-5% by weight Antifoam (10% solution), 0.1-1% by weight of water; 80-85% by weight of mixture 1: Mix Methocel E5, Methocel E15, Talcum, and Titanium Dioxide together according to the formula. 2: Dissolve Polyethylene Glycol 6000 and Antifoam in water according to the formula. Pour mixture 1 into mixture 2 and grind both mixtures until a smooth, homogeneous mixture is obtained. Then use it to coat the tablets. The second film coating formula for core tablets consists of: Methocel E5 (formula) 1-5% by weight, Methocel E15 (formula) 1-5% by weight, Titanium Dioxide 5-10% by weight, Talcum 1-5% by weight, and Brilliant Blue (Aluminium Lake). 1-3% by weight Tartrazine (Aluminium Lake), 0.1-2% by weight Polyethylene Glycol 6000, 1-5% by weight Antifoam (10% solution), 0.1-1% by weight Water, 80-85% by weight. Mixture 1: Mix Mettocell E5, Mettocell E15, Talcum, Titanium Dioxide, Brilliant Blue, and Tartrazine according to the formula. Mixture 2: Dissolve Polyethylene Glycol 6000 and Antifoam according to the formula in water. Add Mixture 1...Pour into the second mixture and grind both mixtures until a smooth, homogeneous mixture is obtained, then use it to coat the tablets. ---------------------1. The manufacturing process and formula for relieving nervous system symptoms from Mucuna pruriens and banana blossom are as follows: a.The formulation of a nutritional pharmaceutical product for relieving nervous system symptoms from Mucuna pruriens and Curcuma longa in the form of film-coated tablets consists of a core tablet containing Mucuna pruriens extract (10-15% by weight), corn starch (1-5% by weight), lactose (55-70% by weight), talcum (1-3% by weight), magnesium stearate (1-3% by weight), and PVPK-30 (5-10% by weight). Gelatin (1-5%) by weight is the standard film coating formula of the core tablet of the pharmaceutical nutraceutical product for relieving neurological symptoms from Mucuna pruriens and Musa acuminata. The first layer of the film coating of the core tablet consists of: Methocel E5 (formula) 1-5% by weight, Methocel E15 (formula) 1-5% by weight, Titanium dioxide 5-10% by weight, Talcum 1-5% by weight, Polyethylene glycol 6000 1-5% by weight, Antifoam (10% solution) 0.1-1% by weight water, 80-85% by weight second film coating of the core tablet: Methocel E5 (formula) 1-5% by weight, Methocel E15 (formula) 1-5% by weight, Titanium dioxide 5-10% by weight, Talcum 1-5% by weight, Brilliant Blue (Aluminium Lake) 1-3% by weight, Tartrazine (Aluminium Lake) 0.1-2% by weight, Polyethylene glycol 6000 1-5% by weight, Antifoam (10% solution) 0.1-1% by weight, Water 80-85% by weight.The manufacturing process for the nutraceutical product for relieving nervous system symptoms from Mucuna pruriens (Vitamin Bryo) in film-coated tablet form is as follows: The core tablet manufacturing process involves the following steps: Prepare granules using the "wet granulation" method. Mix lactose, corn starch, and PVP-K-30 together, then gradually pour the Mucuna pruriens extract into the mixture and mix thoroughly. Dissolve gelatin in 8-9% water (volume / weight of the formula) as a wetting agent to help moisten the powder. The wet granules are sieved and then dried at 50°C. The dried granules are sieved again, then mixed with talcum and magnesium stearate, and pressed into tablets. The manufacturing process for the pharmaceutical nutraceutical product for relieving nervous system symptoms from Mucuna pruriens and banana blossom is as follows, specifically for the film coating of the core tablets: First layer film coating: Mixture 1: Mix methocell E5, methocell E15, talcum, and titanium dioxide together. Mixture 2: Dissolve polyethylene glycol 6000 and antifoam in water. Then, use mixture 1...Pour into mixture 2 and grind both mixtures until a smooth, homogeneous mixture is obtained. Then use it to coat the tablets. For the second layer of the core film coating, mix Tosel E15, talcum, titanium dioxide, beryllium blue, and tartrazine together. For mixture 2, dissolve polyethylene glycol 6000 and antifoam in water. Pour mixture 1 into mixture 2 and grind both mixtures until a smooth, homogeneous mixture is obtained. Then use it to coat the tablets.