Liquid components for oral use.

Abstract

DEPCT66 The purpose of this invention is to provide an orally administered liquid formulation containing an extract. Derived from plants, it has a good feel when used and a sufficiently stable appearance, and can provide results. The medicinal properties of plant extracts are adequately provided by this invention; that is, it provides the necessary components. Oral liquids that include (A) one or more types of plant-derived extracts, (B) Sodium chloride and (C) anionic surfactant. -----------------------------------------------------------

Description

liquid oral composition

[0001] The present invention relates to a liquid oral composition.

[0002] Plant-derived extracts are blended into toothpastes as functional and effective ingredients from the perspective of periodontal disease care and caries care, and they also provide a noticeable tightening effect. However, when blended at effective and noticeable concentrations in liquid oral preparations such as liquid toothpastes, mouthwashes, and mouth sprays, which do not normally require rinsing with water after use, the plant-derived extracts can cause an unpleasant feeling in the throat after use, and can also cause issues with formulation stability, such as the generation of sediment and turbidity.

[0003] Patent Document 1 describes that an oral care composition containing an active compound from a magnolia extract, a non-surfactant electrolyte, etc., has long-term stability. Patent Document 2 describes that an oral composition containing a plant extract and predetermined amounts of N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide provides a refreshing feeling and reduces irritation.

[0004] Patent Publication No. 2014-505077 International Publication No. 2018 / 221621

[0005] However, none of the conventional technologies have been able to sufficiently and balancedly suppress the occurrence of discomfort after use caused by plant-derived extracts and improve the formulation stability.

[0006] The present invention aims to provide a liquid oral composition that contains a plant-derived extract, has a good feel when used and good appearance stability, and is capable of fully exerting the medicinal efficacy of the plant-derived extract.

[0007] The present invention provides the following: [1] (A) one or more plant-derived extracts selected from rosemary, Scutellaria root, carrot, sage, licorice, Angelica sinensis, tea, Phellodendron bark, Kuromoji, peony, clove, perilla, hamamelis, guava, Quercus salicina, amla, bamboo, aloe vera, Chinese cedar, Centella asiatica, magnolia, shell ginger, calendula, chamomile, soapberry, myrrh, ginger, propolis, eucalyptus, persimmon, sword bean, olive, Japanese pepper, thyme, birch, Asca oleracea, turmeric, stevia, marjoram, melissa, laurel, cola, Monk fruit, camellia, allspice, Sappan root, Lithospermum root, Rhubarb, Forsythia fruit, Tangerine peel, cinnamon bark, oregano, basil, basil sage, Peony root, Myrobalan, pine bark, evening primrose, and saxifrage; A liquid oral composition containing (B) sodium chloride, and (C) anionic surfactant. [2] The composition according to [1], wherein the content of the (A) component (pure extract) is 0.0001 to 0.1% by mass. [3] The composition according to [1] or [2], wherein the content of the (B) component is 0.1 to 2% by mass. [4] The composition according to any one of [1] to [3], wherein the content of the (C) component is 0.01 to 1% by mass. [5] The composition according to any one of [1] to [4], further containing (D) a nonionic surfactant.

[0008] According to the present invention, a liquid oral composition can be provided that contains a plant-derived extract, has a good feel when used and good appearance stability, and is able to fully exert the medicinal efficacy of the plant-derived extract.

[0009] The present invention will be described in detail below with reference to preferred embodiments thereof. In this specification, the content of each component is a value based on the amount of each component charged when preparing the composition.

[0010] [1. Liquid Oral Composition] In the present invention, the composition contains components (A) to (C), and preferably further contains component (D).

[0011] [(A) Plant-Derived Extract] Component (A) is a plant-derived extract. By containing component (A), a tightening sensation can be exhibited. Furthermore, if component (A) has other physiological activities, the other physiological activities can be exhibited in addition to the tightening sensation.

[0012] -Plants- The plant-derived extract (plant-derived component) may be an extract derived from at least a part of the raw plant (it may be an unextracted secretion such as sap), and is preferably an extract containing hydrophilic components such as polyphenols, and more preferably an extract that can exert a firming effect. Examples of plant species include rosemary, Scutellaria root, carrot, sage, licorice, angelica tree, tea, Phellodendron bark, Kuromoji, peony, clove, perilla, hamamelis, guava, oak, amla, bamboo, aloe vera, Chinese cedar, Centella asiatica, magnolia, shell ginger, calendula, chamomile, soapberry, myrrh, ginger, propolis, eucalyptus, persimmon, sword bean, olive, Japanese pepper, thyme, white birch, asafoetida, turmeric, stevia, marjoram, melissa, laurel, cola, monk fruit, camellia, allspice, Sappan root, Lithospermum root, Rhubarb, Forsythia, Tangerine peel, cinnamon bark, oregano, basil, basil sage, moutan seed oil, balsam myrobalan, pine bark, evening primrose, and saxifrage. The parts to be extracted include, for example, leaves, stems, roots, flowers, seeds, and combinations thereof, and may be appropriately selected depending on the plant species and extraction method.

[0013] -Extraction- Examples of extraction solvents include water, polar solvents, nonpolar solvents, and mixed solvents thereof. Examples of polar solvents include ethyl ether, ethylene chloride, dioxane, acetone, alcohols (e.g., lower monohydric alcohols having 1 to 5 carbon atoms, such as ethanol, methanol, propyl alcohol, and isopropyl alcohol), glycols (e.g., propylene glycol and butylene glycol), ethyl acetate, and glycerin. Examples of nonpolar solvents include n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, and benzene. Among these, hydrophilic solvents are preferred, and water, lower monohydric alcohols having 1 to 5 carbon atoms, glycols, and mixed solvents combining two or more selected from these are more preferred. Mixed solvents are preferably mixed solvents of water and lower monohydric alcohols or glycols, and more preferably mixed solvents in which the mixing ratio of water to lower monohydric alcohols or glycols is 10:90 to 90:10 (mass ratio). Examples of extraction methods include a method in which a sample is taken from the part of the plant to be extracted, crushed if necessary, and then extracted using an extraction solvent, and a method in which the extraction residue obtained after extraction is used as a raw material and subjected to an extraction process using the above-mentioned solvent.

[0014] -Examples of Plant-Derived Extracts- As component (A), plant-derived extracts obtained from the above plants can be used, and commercially available products may also be used. Preferred examples are as follows:

[0015] Rosemary extract: For example, an extract obtained by extracting rosemary (Rosmarinus officinalis L.) leaves using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or a mixed solvent of two or more selected therefrom.

[0016] Scutellaria root extract: For example, an extract extracted from the root of Scutellaria root (Scutellaria baicalensis) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or a mixed solvent of two or more selected therefrom.

[0017] Ginseng extract: For example, an extract obtained by extracting the roots of ginseng (Panax ginseng) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or a mixed solvent of two or more selected therefrom.

[0018] Sage extract: For example, an extract obtained by extracting sage (Salvia officinalis) leaves using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or a mixed solvent of two or more selected therefrom.

[0019] Licorice extract: For example, an extract obtained by extracting the root of licorice (e.g., Glycyrrhiza uralensis Fisher, Glycyrrhiza glabra Linne) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or a mixed solvent of two or more selected therefrom.

[0020] Angelica acutiloba extract: For example, an extract obtained by extracting the roots of Angelica acutiloba using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or a mixed solvent of two or more selected therefrom.

[0021] Tea extract: For example, an extract extracted from tea (Camellia sinensis) leaves using water, glycol (e.g., 1,3-butylene glycol), or a mixed solvent of two or more selected therefrom.

[0022] Phellodendron amurensis extract: For example, an extract obtained by extracting the bark of Phellodendron amurensis using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or a mixed solvent of two or more selected therefrom.

[0023] Kuromoji extract: For example, an extract extracted from the bark of Kuromoji (Lindera umbellata) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or a mixed solvent of two or more selected therefrom.

[0024] Peony extract: For example, an extract obtained by extracting the roots of peony (Paeonia lactiflora) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0025] Perilla extract: An extract extracted from the leaves of (Perilla frutescens var. crispa) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0026] Hamamelis extract: An extract obtained by extracting the leaves and / or bark of Hamamelis virginiana using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0027] Shell ginger extract: For example, an extract obtained by extracting from the leaves of Alpinia zerumbet using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0028] Saxifraga extract: For example, an extract obtained by extracting the whole plant of Saxifraga stolonifera Curtis with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom, or a 1% urea-containing ethanol solution, or a 1% urea-containing 1,3-butylene glycol solution.

[0029] Calendula officinalis extract: For example, an extract obtained by extracting the flower heads of Calendula officinalis (Calendula officinalis L.) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0030] Sapindus mukorossi extract: For example, an extract extracted from the peel of Sapindus mukorossi (Sapindus mukorossi Gaertn.) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0031] Chamomile extract: For example, an extract obtained by extracting chamomile (Matricaria chamomilla L.) flowers using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0032] Pine bark extract: For example, an extract obtained by extracting the bark of French maritime pine (Pinus pinaster) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or two or more hydrophilic solvents selected therefrom.

[0033] Evening primrose extract: An extract obtained by extracting from parts such as seeds of evening primrose, such as evening primrose (Oenothera striata), evening primrose (Oenothera biennis), evening primrose (Oenothera laciniata), and evening primrose (Oenothera erythrosepala), using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0034] Sword bean extract: For example, an extract obtained by extracting sword bean (Canavalia gladiata (Jacq.) DC.) beans (e.g., roasted beans) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0035] Aloe vera extract: For example, an extract obtained by extracting Aloe vera leaves or their juice using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0036] Salvadora persica (bark & ​​root) extract: For example, an extract extracted from the bark or root of Salvadora persica (bark & ​​root) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0037] Clove extract: For example, an extract obtained by extracting dried buds of Syzygium aromaticum (L.) Merr. & L. M. Perry (Eugenia caryophyllata Thumb.) from the clove tree using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0038] Centella extract: For example, an extract obtained by extracting leaves and / or stems of Centella (Centella asiatica (L.) Urb.) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0039] Eucalyptus extract: For example, an extract obtained by extracting the leaves of eucalyptus (e.g., Eucalyptus globulus Labill.) or its related plants (Myrtaceae) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0040] Persimmon extract: For example, an extract obtained by extracting from the fruit or peel of a persimmon tree (Diospyros kaki Thumb.) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or two or more hydrophilic solvents selected therefrom.

[0041] Thyme extract: For example, an extract obtained by extracting the aerial parts of Thymus serpyllum L. or Thymus vulgaris L. using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0042] Birch extract: For example, an extract obtained by extracting the leaves, bark, or wood of European birch (Betula pendula Roth) or other plants of the same genus using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0043] Uncaria extract: For example, an extract obtained by extracting leaves and young branches of Uncaria gambir (W. Hunter) Roxb. (Rubiaceae) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0044] Turmeric extract: For example, an extract extracted from the rhizome of turmeric (Curcuma longa L.) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0045] Stevia extract: For example, an extract obtained by extracting from the aerial parts of stevia (Stevia rebaudiana (Bertoni) Bertoni), such as leaves, using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0046] Zanthoxylum piperitum (L.) DC. extract: For example, an extract obtained by extracting the pericarp of Zanthoxylum piperitum (L.) DC. or a plant of the same genus using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0047] Melissa extract: For example, an extract obtained by extracting leaves of Melissa officinalis L. with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom, or a 1% urea-containing ethanol solution, or a 1% urea-containing 1,3-butylene glycol solution.

[0048] Monk fruit extract: For example, an extract obtained by extracting the fruit of Monk fruit (Siraitia grosvenorii) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or two or more hydrophilic solvents selected therefrom.

[0049] Camellia extract: For example, an extract obtained by extracting defatted seeds of camellia (Camellia japonica L.) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom, or a 1% urea-containing ethanol solution, or a 1% urea-containing 1,3-butylene glycol solution.

[0050] Lithospermum erythrorhizon Siebold & Zucc. root extract: For example, an extract obtained by extracting the root of Lithospermum erythrorhizon Siebold & Zucc. with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom, or a 1% urea-containing ethanol solution, or a 1% urea-containing 1,3-butylene glycol solution.

[0051] Rheum extract: For example, an extract obtained by extracting, typically from a part such as the rhizome, of a plant of the genus Rheum (e.g., Rheum palmatum Linne, Rheum tanguticum Maximowicz, Rheum officinale Baillon, Rheum coreanum Nakai, or an interspecific hybrid thereof with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or two or more hydrophilic solvents selected from these.

[0052] Forsythia extract: For example, an extract obtained by extracting forsythia (Forsythia suspensa Vahl) fruit with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or two or more hydrophilic solvents selected therefrom.

[0053] Citrus unshiu extract: For example, an extract obtained by extracting the mature peel of Unshiu mandarin (Citrus unshiu (Swingle) Marcow. or Citrus reticulata Blanco) or other related plants (family Rutaceae) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom, or a 1% urea-containing ethanol solution, or a 1% urea-containing 1,3-butylene glycol solution.

[0054] Cinnamon bark extract: For example, an extract of the bark or periderm of cinnamon bark (Cinnamomum cassia Blume (Lauraceae)) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or two or more hydrophilic solvents selected therefrom.

[0055] Guava extract: For example, an extract obtained by extracting the fruit and / or leaves of guava (Psidium guajava) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0056] Quercus salicina extract: For example, an extract obtained by extracting Quercus salicina leaves using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0057] Amla extract: For example, amla extract obtained from the fruit of amla (Phyllanthus emblica L.) in a solvent such as water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0058] Bamboo extract: For example, an extract extracted from the epidermis of Moso bamboo (Phyllostachys heterocycla f. pubescens) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0059] Magnolia extract: For example, an extract obtained by extracting the flowers, buds, or bark of magnolia (Magnolia liliiflora) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0060] Myrrh: e.g., secretions from trees of the Myrrh genus (e.g., Commiphora myrrha)

[0061] Ginger extract: For example, an extract obtained by extracting ginger (Zingiber officinale (Willd.) Roscoe) root using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0062] Propolis: a resinous mixture collected by, for example, honeybees from tree buds, sap, or other plant sources

[0063] Olive extract: For example, an extract obtained by extracting olive (Olea europaea) leaves, flowers, fruits, or stems using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0064] Marjoram extract: For example, an extract extracted from marjoram (Origanum majorana L.) leaves using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0065] Laurel extract: For example, an extract obtained by extracting leaves such as dried leaves of Laurus nobilis using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or two or more hydrophilic solvents selected therefrom.

[0066] Cola extract: For example, an extract obtained by extracting from the seeds of a cola tree using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0067] Allspice extract: For example, an extract obtained by extracting allspice (Pimenta dioica) fruit using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0068] Sappan extract: For example, an extract obtained by extracting the bark or stem of Sappan (Caesalpinia sappan L.) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0069] Oregano extract: An extract obtained by extracting at least a portion of oregano (Origanum vulgare) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0070] Basil extract: An extract obtained by extracting at least a portion of basil (Ocimum basilicum L.) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0071] Elsholtzia ciliata (Thumb.) Hyl. extract: an extract obtained by extracting at least a portion of Elsholtzia ciliata (Thumb.) Hyl. using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected from these.

[0072] Peony extract: For example, an extract obtained by extracting the root bark of Paeonia suffruticosa Andrews (Paeonia moutan Sims) using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1,3-butylene glycol), or two or more hydrophilic solvents selected therefrom.

[0073] Terminalia bellirica extract: For example, an extract obtained by extracting the fruit of Terminalia bellirica using water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), or two or more hydrophilic solvents selected therefrom.

[0074] The component (A) may be a single plant-derived extract or a combination of two or more plant-derived extracts.

[0075] - Content of Component (A) - The content of component (A) (pure extract content) is typically 0.00001% by mass or more, and preferably 0.0001% by mass or more, relative to the total amount of the composition. This provides the firming sensation that component (A) provides, and also allows the physiological activity of component (A) to be exerted. The upper limit is typically 0.5% by mass or less, and preferably 0.1% by mass or less. This particularly suppresses the occurrence of bitterness, sweetness, or other unpleasant sensations in the throat, as well as sediment and turbidity. Therefore, the content of component (A) is typically 0.00001 to 0.5% by mass, and preferably 0.0001 to 0.1% by mass.

[0076] [(B) Sodium Chloride] Component (B) is sodium chloride. By including component (B), the discomfort in the throat caused by component (A) can be alleviated and a feeling of firmness can be achieved.

[0077] -Content of Component (B)- The content of component (B) is typically 0.05% by mass or more, and preferably 0.1% by mass or more, relative to the total amount of the composition. This particularly suppresses the occurrence of an unpleasant feeling due to component (A). The upper limit is typically 3% by mass or less, and preferably 2% by mass or less. This particularly suppresses the occurrence of an unpleasant feeling due to the salty taste of component (B) and the occurrence of sediment and cloudiness. Therefore, the content of component (B) is typically 0.05 to 3% by mass, and preferably 0.1 to 2% by mass.

[0078] [(C) Anionic Surfactant] Component (C) is an anionic surfactant. By including component (C), appearance stability such as suppression of condensation and clouding can be achieved.

[0079] Examples of Anionic Surfactants: Examples of anionic surfactants include alkyl sulfates, acylamino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and alkyl sulfoacetates. When an alkyl group is present, the alkyl group may be either linear or branched, saturated or unsaturated, and typically has 12 to 14 carbon atoms. When an acyl group is present, the acyl group may be either linear or branched, saturated or unsaturated, and typically has 10 to 20 carbon atoms. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts, lysine salts, and histidine salts. Among these, inorganic base salts are preferred, alkali metal salts (for example, sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0080] Examples of alkyl sulfates include lauryl sulfate and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt and N-methyl-N-acylalanine salt; and acyl aspartates such as lauroyl aspartate. Examples of acyltaurine salts include lauroyl methyl taurine salt, N-methyl-N-acyltaurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonates include α-olefin sulfonates having 12 to 14 carbon atoms, such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate and sodium lauryl sulfoacetate.

[0081] The component (C) may be a single anionic surfactant or a combination of two or more anionic surfactants.

[0082] -Content of Component (C)- The content of component (C) is typically 0.001% by mass or more, preferably 0.01% by mass or more, based on the total amount of the composition. This particularly suppresses the generation of turbidity and allows for good foaming. The upper limit is typically 3% by mass or less, preferably 1% by mass or less. This particularly suppresses the generation of bitterness or irritation due to anionic surfactants. Therefore, the content of component (C) is typically 0.001 to 3% by mass, preferably 0.01 to 1% by mass.

[0083] -(B) / (C)- The mass ratio of the component (B) to the component (C) ((B) / (C)) is usually 0.1 or more, and preferably 0.3 or more, from the viewpoint of exerting the effects of the present invention, and the upper limit is usually 50 or less, and preferably 30 or less, 20 or less, or 10 or less.

[0084] [(D) Nonionic Surfactant] The component (D) is a nonionic surfactant. By incorporating the component (D), particularly good stability of appearance can be achieved, such as further suppressing the occurrence of condensation and cloudiness.

[0085] -Nonionic Surfactants- Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is typically 14 to 18, and the average number of moles of ethylene oxide added is typically 15 to 30 moles. The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is typically 20 to 100 moles, preferably 60 to 100 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As the nonionic surfactant, polyoxyethylene hydrogenated castor oil is preferred.

[0086] -Content of Component (D)- The content of component (D) is typically 0.01% by mass or more, preferably 0.05% by mass or more, based on the total amount of the composition. This allows the effects of component (D) to be exerted, and the generation of cloudiness can be sufficiently suppressed. The upper limit is typically 3% by mass or less, preferably 2% by mass or less. This allows the generation of the strange taste characteristic of nonionic surfactants and the generation of oil and cloudiness to be suppressed. Therefore, the content of component (D) is typically 0.01 to 3% by mass, preferably 0.05 to 2% by mass.

[0087] [Optional Components] The composition may contain components other than components (A) to (D). The other components may be any components that do not impair the solubility in the solution, such as humectants, solvents, medicinal components, flavorings, thickeners, viscosifiers, preservatives, sweeteners, surfactants other than component (D), and pH adjusters, and can be selected from components that can be incorporated into liquid oral compositions.

[0088] -Humectant- The inclusion of a humectant in the composition can further improve the feel upon use. The humectant is preferably a polyhydric alcohol, and examples thereof include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, and xylitol; glycerin; glycols such as ethylene glycol, polyethylene glycol (molecular weight 200 to 6000), and propylene glycol; and reduced starch saccharification products. The content of the humectant is typically 1 to 50% by mass, and preferably 2 to 20% by mass, of the total amount of the composition.

[0089] -Solvent- Examples of the solvent include water, a lower monohydric alcohol (e.g., ethanol), and a mixed solvent thereof. The amount of the solvent is usually 50% by mass or more, preferably 60 to 99.5% by mass, based on the total amount of the composition. In the case of a mixed solvent, the amount of the lower monohydric alcohol added is usually 1 to 30% by mass, preferably 1 to 20% by mass, based on the total amount of the composition.

[0090] -Medicinal Ingredients (Other than Ingredients (A) and (B))- Examples of medicinal ingredients other than ingredients (A) and (B) include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; enzymes such as dextranase, mutanase, amylase, protease, and Liteque Enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; anti-inflammatory agents such as ε-aminocaproic acid, allantoin, tranexamic acid, glycyrrhizinate (for example, glycyrrhizin dipotassium salt), glycyrrhetinate, aluminum chlorohydroxyallantoin, azulene, and dihydrocholesterol; metal salts such as zinc, copper salts, and tin salts; and condensed phosphate Examples of the medicinal ingredient include anti-calculus agents such as salts and ethanehydroxydiphosphonate; blood flow promoters such as vitamin E (e.g., tocopherol acetate); anti-dentin hypersensitivity agents such as potassium nitrate, aluminum lactate, and strontium chloride; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; astringents other than component (B) such as allantoin chlorohydroxyaluminum, vitamins (e.g., vitamin C), lysozyme chloride, and glycyrrhetinic acid and its salts; water-soluble copper compounds such as copper chlorophyll and copper gluconate; anti-calculus agents such as zeolites, amino acids such as alanine, glycine, and proline; plant extracts other than component (A); caropeptide, polyvinylpyrrolidone, sodium lauroyl sarcosinate, anti-calculus agents, and anti-plaque agents. The content of the medicinal ingredient can be appropriately determined to be an effective amount.

[0091] - pH Adjuster - The inclusion of a pH adjuster in the composition ensures the pH stability of the formulation. Examples of pH adjusters include organic acids or salts thereof, such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid; inorganic acids, such as hydrochloric acid and phosphoric acid (orthophosphoric acid); and inorganic salts, such as sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate. The content of the pH adjuster is typically an amount that results in a pH of 5 to 9, preferably 6 to 8.5, after addition of the pH adjuster. In this specification, the pH value is typically measured at 25°C and 3 minutes after the start of measurement, and can be measured using a pH meter (model Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0092] -Fragrance- The composition can improve the sensation of use by containing a fragrance. Examples of fragrances include natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, orange oil, nutmeg oil, lavender oil, paracles oil, cinnamon oil, pimento oil, cinnamon leaf oil, and perilla oil; menthol, 1-carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spilanthol, n-decyl alcohol, citronellol, α- These include fragrance components contained in the above-mentioned natural essential oils, such as terpineol, citronellyl acetate, cineole, ethyl linalool, and vanillin; fragrance components such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, and ethylene glycol-1-menthyl carbonate; and various blended flavors, such as mint, fruit, and herb flavors, which are obtained by combining several fragrance components and natural essential oils. The fragrances may be used alone or in combination of two or more. The content of the fragrance is typically 0.00001 to 3% by mass based on the total amount of the composition.

[0093] Sweeteners The composition can further improve the texture when used by including a sweetener, such as xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame, or sucralose.

[0094] -Surfactant (Other than Components (C) and (D))- Examples of surfactants other than components (C) and (D) include amphoteric surfactants. Examples of amphoteric surfactants include acetate betaine-type amphoteric surfactants such as alkyl dimethylamino acetic acid betaine (e.g., lauryl dimethylamino acetic acid betaine) and fatty acid amidopropyl dimethylamino acetic acid betaine (e.g., cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts (e.g., N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut oil fatty acid imidazolium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; and alkyl betaines such as lauryl dimethylamino acetic acid betaine. The surfactant content (total amount including components (C) and (D)) is usually 0.1 to 4 mass%, preferably 0.2 to 3 mass%, of the total amount of the liquid oral composition.

[0095] [Uses] The composition of the present invention is preferably a liquid oral composition, and more preferably a mouthwash (including undiluted and concentrated types), a liquid dentifrice, or a mouth spray composition. When commercializing the composition, a container made of a material such as PET (polyethylene terephthalate), glass, polypropylene, or polyethylene can be used, and from the viewpoint of suppressing adsorption of flavorings, it is preferable to use a container made of PET or glass.

[0096] The method of using the liquid oral composition of the present invention is not particularly limited. For example, the liquid oral composition of the present invention may be used by holding an appropriate amount of the composition in the mouth, rinsing the mouth for a predetermined time (usually about 10 to 30 seconds), spitting it out, and then brushing the teeth as needed, or by spraying it into the mouth.

[0097] The present invention will be described in more detail below with reference to examples. The following examples are provided to suitably explain the present invention, but are not intended to limit the present invention. The methods for measuring physical properties are as described above unless otherwise specified. "%" means "% by mass" unless otherwise specified.

[0098] (Examples 1 to 24 and Comparative Examples 1 to 4) Liquid oral compositions (mouthwashes) of the present invention were prepared by the following preparation method according to the blending amounts shown in Tables 1 to 5. The obtained mouthwashes were evaluated by the following method. The results are also shown in Tables 1 to 5.

[0099] [Method of preparing mouthwash] The mouthwash was prepared by sequentially adding the ingredients to purified water according to the composition shown in the table, stirring, and dissolving uniformly. A Three-One Motor (BL1200, manufactured by HEIDON) was used for the production.

[0100] Details of each ingredient are given below. Component A Licorice extract: Licorice extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) Rosemary extract: Rosemary extract-J (manufactured by Maruzen Pharmaceutical Co., Ltd.) Scutellaria root extract: Scutellaria root extract-J (manufactured by Maruzen Pharmaceutical Co., Ltd.) Ginseng extract: Ginseng extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) Sage extract: Salvia extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) Angelica acutiloba extract: Angelica acutiloba extract-JC (manufactured by Maruzen Pharmaceutical Co., Ltd.) Tea extract: Wa-ism (registered trademark) <Green Tea> (manufactured by Maruzen Pharmaceutical Co., Ltd.) Phellodendron bark extract: Phellodendron bark extract (manufactured by Ogi Pharmaceutical Co., Ltd.) Kuromoji extract: Kuromoji extract (manufactured by Japan Kampo Medicine Research Institute) Peony extract: Peony extract-J (manufactured by Maruzen Pharmaceutical Co., Ltd.) Perilla extract: Perilla extract BG (manufactured by Maruzen Pharmaceutical Co., Ltd.) Hamamelis extract: Hamamelis extract BG-J (manufactured by Maruzen Pharmaceutical Co., Ltd.) Component B: Sodium chloride (manufactured by Nihon Kaisui Co., Ltd.) Component C: Sodium lauryl sulfate (manufactured by BASF) Sodium lauroyl sarcosinate (manufactured by Kawaken Fine Chemicals Co., Ltd.) Sodium lauroyl methyl taurate (manufactured by Nikko Chemicals Co., Ltd.) Sodium tetradecene sulfonate (manufactured by Lion Specialty Chemicals Co., Ltd.) Sodium lauroyl glutamate (manufactured by Asahi Kasei Corporation) Component D: Polyoxyethylene (POE) (60) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd.) Other components: Citric acid (manufactured by Fuso Chemical Co., Ltd.) Sodium citrate (manufactured by Fuso Chemical Co., Ltd.) Ingredients other than those mentioned above that complied with the Standards for Quasi-drug Raw Materials 2006 were used.

[0101] [Evaluation method] (1) Evaluation of usability (effect of reducing discomfort associated with sweetness and bitterness felt in the throat due to plant extracts) 10 mL of the mouthwash (sample) shown in the table was placed in the mouth, rinsed for 30 seconds, and then spit out. The usability (lack of discomfort in the throat, pleasant aftertaste) was evaluated on the following four-point scale, and the average scores of 10 panelists are shown in the table as ++, +, ±, - according to the following criteria.

[0102] ●No discomfort in the throat after use Rating criteria 4: No discomfort in the throat at all 3: Almost no discomfort in the throat 2: Some discomfort in the throat 1: Strong discomfort in the throat Evaluation criteria ++: Average score of 3.5 to 4.0 points +: Average score of 3.0 to less than 3.5 points ±: Average score of 2.0 to less than 3.0 points -: Average score of 1.0 to less than 2.0 points

[0103] ●Good aftertaste after use Rating criteria 4: Very good aftertaste 3: Slightly good aftertaste 2: Slightly bad aftertaste 1: Very bad aftertaste Evaluation criteria ++: Average score of 3.5 to 4.0 points +: Average score of 3.0 to less than 3.5 points ±: Average score of 2.0 to less than 3.0 points -: Average score of 1.0 to less than 2.0 points

[0104] (2) Evaluation of appearance stability (effect of suppressing turbidity) Rating criteria ++: When the PET container is inspected, no turbidity or sediment is observed. +: When the PET container is inspected, slight turbidity and sediment are observed, but this is not a problem. ±: When the PET container is inspected, turbidity and sediment are observed. -: When the PET container is inspected, turbidity and sediment are clearly observed.

[0105] (3) Evaluation method for effectiveness (feeling of gum tightening): Approximately 10 ml of the sample (liquid oral composition) was placed in the mouth and rinsed for 30 seconds, after which the feeling of effectiveness (feeling of gum tightening) after rinsing was evaluated using the following four-point rating scale. The average of the evaluation results of 10 people was calculated and evaluated using the following criteria. A score of + or higher was considered a pass.

[0106] Rating criteria: 4 points: There was a sufficient feeling of gum tightening. 3 points: There was a slight feeling of gum tightening. 2 points: There was almost no feeling of gum tightening. 1 point: There was no feeling of gum tightening. Evaluation criteria: ++: Average score of 3.5 points or more and 4.0 points or less +: Average score of 3.0 points or more and less than 3.5 points ±: Average score of 2.0 points or more and less than 3.0 points -: Average score less than 2.0 points

[0107]

[0108]

[0109]

[0110]

[0111]

[0112] Comparative Example 1, which did not contain licorice extract, did not provide a sufficient firming sensation. Comparative Example 2, which contained licorice extract and sodium lauryl sulfate but no sodium chloride, and Comparative Example 3, which contained licorice extract and sodium chloride but no sodium lauryl sulfate, were insufficient or poor in terms of either usability, firming sensation, or turbidity suppression (Table 5). In contrast, Examples 1 to 24, which contained various plant extracts, sodium chloride, and various anionic surfactants in various proportions, were rated as good in all evaluation categories (Tables 1 to 4). These results demonstrate that the liquid oral composition of the present invention has good usability and appearance stability and can exert the medicinal effects of the plant extracts.

[0113] The following are examples of formulations for the liquid oral composition (mouthwash) of the present invention. The extracts used in each formulation are those exemplified in the specification.

[0114] Formulation Example 1 Shell ginger extract 0.02% by mass Sodium chloride 0.3% by mass Sodium lauryl sulfate 0.2% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Xylitol 4% by mass Glycerin 2% by mass Fragrance 0.1% by mass Purified water Balance Total 100% by mass

[0115] Formulation Example 2 Saxifraga extract 0.02% by mass Sodium chloride 0.3% by mass Sodium lauryl sulfate 0.2% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Xylitol 4% by mass Glycerin 2% by mass Fragrance 0.1% by mass Purified water Balance Total 100% by mass

[0116] Formulation Example 3 Calendula extract 0.02% by mass Sodium chloride 0.3% by mass Sodium lauryl sulfate 0.2% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Xylitol 4% by mass Glycerin 2% by mass Fragrance 0.1% by mass Purified water Balance Total 100% by mass

[0117] Formulation Example 4 Soapberry extract 0.02% by mass Sodium chloride 0.3% by mass Sodium lauryl sulfate 0.2% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Xylitol 4% by mass Glycerin 2% by mass Fragrance 0.1% by mass Purified water Balance Total 100% by mass

[0118] Formulation Example 5 Chamomile extract 0.02% by mass Sodium chloride 0.3% by mass Sodium lauryl sulfate 0.2% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Xylitol 4% by mass Glycerin 2% by mass Fragrance 0.1% by mass Purified water Balance Total 100% by mass

[0119] Formulation Example 6 Pine bark extract 0.02% by mass Sodium chloride 0.3% by mass Sodium lauryl sulfate 0.2% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Xylitol 4% by mass Glycerin 2% by mass Fragrance 0.1% by mass Purified water Balance Total 100% by mass

[0120] Formulation Example 7 Evening primrose extract 0.02% by mass Sodium chloride 0.3% by mass Sodium lauryl sulfate 0.2% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Xylitol 4% by mass Glycerin 2% by mass Fragrance 0.1% by mass Purified water Balance Total 100% by mass

[0121] Formulation Example 8: Sword bean extract 0.02% by mass, sodium chloride 0.3% by mass, sodium lauryl sulfate 0.2% by mass, citric acid 0.05% by mass, sodium citrate 0.3% by mass, polyoxyethylene (60) hydrogenated castor oil 0.5% by mass, xylitol 4% by mass, glycerin 2% by mass, fragrance 0.1% by mass, purified water, balance: total 100% by mass

[0122] Formulation Example 9 Aloe vera extract 0.02% by mass Sodium chloride 0.3% by mass Sodium lauryl sulfate 0.2% by mass Citric acid 0.05% by mass Sodium citrate 0.3% by mass Polyoxyethylene (60) hydrogenated castor oil 0.5% by mass Xylitol 4% by mass Glycerin 2% by mass Fragrance 0.1% by mass Purified water Balance Total 100% by mass

[0123] Formulation Example 10: Cedar extract 0.02% by mass, sodium chloride 0.3% by mass, sodium lauryl sulfate 0.2% by mass, citric acid 0.05% by mass, sodium citrate 0.3% by mass, polyoxyethylene (60) hydrogenated castor oil 0.5% by mass, xylitol 4% by mass, glycerin 2% by mass, fragrance 0.1% by mass, purified water, balance: total 100% by mass

Claims

DEPCT661. Oral liquid components containing: (A) one or more selected plant extracts from licorice, Japanese angelica root, tea, cork bark, kuromoch, peony, perilla, hamamelis, rosemary, scutellaria root, ginseng, sage, clove, guava, urajiro-gashi, amla, bamboo, aloe vera, kayusuki, gotu kola, magnolia, galangal, pot marigold, chamomile, soapberry, sandalwood, ginger, propolis, eucalyptus, persimmon, pea, olive, xanthosylum, thyme, silver birch, Gambia, turmeric, stevia, marje Aram, Melissa, Laurel, Cola, Luo Han Guo, Camellia, Allspice, Logwood, Cromwell Root, Rhubarb, Forsythia, Dried Citrus Bark, Chinese Cinnamon, Oregano, Basil, Crested Summer Mint, Pomegranate Bark, Terminalia Chebula, Pine Bark, Evening Primrose and Saxifrage; (B) Sodium Chloride; and (C) Anionic Surfactants.

2. Composition according to claim 1 where the amount present of (purified extract) of component (A) is 0.0001 to 0.1% by mass.

3. Composition according to claim 1 or 2 where the amount present of component (B) is 0.1 to 2% by mass. 4.One of the components in Reputations 1 to 3 where the amount of component (C) present is 0.01 to 1% by mass.

5. One of the components in Reputations 1 to 4 which is further combined with (D) a nonionic surfactant.