Novel process for purifying heparan-n-sulfatase.

TN2025000054A1Undetermined Publication Date: 2026-10-01GC BIOPHARMA CORP +1
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Patent Information

Application Number
TN2025000054P0
Authority / Receiving Office
TN · TN
Patent Type
Applications
Current Assignee / Owner
Filing Date
2025-02-21
Publication Date
2026-10-01
Patent Text Reader

Abstract

The present invention relates to a pharmaceutical composition of a high concentration of heparan N-sulfatase (H NS) with enhanced stability for CNS delivery and a pharmaceutical formulation comprising the same. The pharmaceutical composition and pharmaceutical formulation comprising the same according to the present invention have excellent formulation stability, such as a reduction in turbidity and a significant improvement in purity, which may be useful in enzyme replacement therapy (ERT) for the treatment of mucopolysaccharidosis type III.
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