Improved Magnesium Composition and Manufacturing Method for Use in Headache Treatment

Abstract

The invention relates to a dietary supplement developed to alleviate symptoms of migraine and chronic headaches, aiming to reduce the severity and frequency of headaches by protecting nerve cells through its neuroprotective effects. This supplement contains a combination of magnesium bisglycinate, magnesium taurate, coenzyme Q10, vitamin B2, and vitamin B12. Furthermore, the relaxing effect of magnesium salts on muscles and blood vessels contributes to the alleviation of tension headaches.

Description

Magnesium developed for use in treating headaches. Composition and Related Production Method TECHNICAL FIELD The invention aims to be a symptom regulator with regular use in migraine and chronic headaches. magnesium bisglycinate, magnesium taurate, coenzyme Q10, vitamin B2 to provide It relates to a food supplement containing a combination of vitamin B12 and other vitamin components. PREVIOUS TECHNIQUE Food supplements, also known as dietary supplements, contain vitamins, minerals, amino acids, These are products containing plant extracts and enzymes. These products are available in tablet, capsule, and effervescent forms. syrup, drops, spray, sachets, softgel capsules, gummy tablets, and drcaps (cellulose) It is offered in various forms (such as food-based capsules). Food supplements are used to maintain a healthy lifestyle. and additional nutrients to the body to support individual health needs. They provide. Headaches are one of the most common types of pain. If left untreated, they can be severe. This can happen and negatively affect an individual's daily life. The World Health Organization (WHO) About half of adults worldwide experience headaches every year. This indicates that headaches have a significant impact on public health. This shows that it is a universal phenomenon with various and complex causes. It manifests as a symptom. The trigeminal nerve, scalp, blood vessels inside and outside the skull, meninges (brain membranes) (meninges) and sensory signals from the face, mouth, neck, ears, eyes, and throat areas. It has three branches that carry it. Headaches can occur in all age groups and genders. Migraine affects both children and adults. It can occur in adults. However, in adults, women are three times more likely to experience it than men. They are greatly affected. Headaches are quite common in children. They start at an early age. Headaches can develop into migraines during adolescence. Childhood or adolescence. Migraines that appear during this period may eventually turn into tension headaches. 1 Magnesium deficiency may play a role in triggering migraine attacks. Magnesium Supplements have been shown to reduce the frequency and severity of migraines, particularly. Magnesium's vasodilatory effect may alleviate the severity of migraine attacks. Studies show that migraine sufferers have low magnesium levels in their blood and cerebrospinal fluid. Studies have shown that it has certain levels. Migraine sufferers who take magnesium supplements. In patients, a decrease in the frequency and severity of headaches has been observed. The use of magnesium supplements, particularly in women who experience menstrual migraines, can help with headaches. It stands out as an effective method for relieving pain symptoms. Magnesium is essential for many biochemical reactions to occur in the body. It plays a vital role in nervous system and muscle function, as well as energy production. It prevents overstimulation by regulating communication between nerve cells. It helps with chronic pain. Reducing stress and anxiety is of great importance in management. Magnesium, nerve It can alleviate symptoms of stress and anxiety by calming the nervous system. Additionally, it can soothe the nervous system. by controlling the release of neurotransmitters that regulate communication between cells It supports these processes. Migraine is a nervous system disorder involving changes in the electrical activity of the brain. It can be triggered by abnormalities and changes in blood vessels. Magnesium is a natural substance. It acts as a calcium channel blocker; this property allows it to relax blood vessels. and improves blood flow. These effects reduce vasoconstriction (narrowing of blood vessels) associated with migraines. and can help prevent dilation (vasodilation). Magnesium taurate is an amino acid-mineral complex that combines with both taurine and... It combines magnesium's cell membrane stabilizing properties. These two components, It has calming effects and affects nerve cells throughout the central nervous system. It creates a calming effect by inhibiting excitability. Magnesium bisglycinate is a form in which magnesium is chelated with two glycine molecules. This The structure increases the bioavailability of magnesium and is better absorbed by the digestive system. It ensures tolerance. Magnesium bisglycinate, magnesium enzyme activation, ATP While supporting the stabilization of nerve and muscle function, glycine's anti- Thanks to its anti-inflammatory and calming effects, it has positive effects on chronic pain. It creates neurotransmitters with high bioavailability and low gastrointestinal effects. It supports production and plays a vital role in improving overall cellular function. 2 Combinations of different magnesium salts can affect nerve and muscle function in various ways. by supporting mechanisms to reduce muscle spasms, cramps and neuropathic pain It can be effective. Migraine may be related to disruptions in mitochondrial energy production. It is thought that Coenzyme Q10 supports mitochondrial function by promoting energy production. It increases [strength], which can reduce the severity and frequency of migraines. It also provides a strong [strength]. Coenzyme Q10, an antioxidant, reduces oxidative stress by neutralizing free radicals. And in this way, it can help prevent migraine attacks. Riboflavin (vitamin B2) plays an important role in cellular energy production, according to Krebs cycle. In the cycle, it acts as a cofactor, serving as a precursor to flavin mononucleotides. Maintaining the stability of the cell membrane and ensuring the continuation of energy-dependent cellular functions. It is essential for providing [health]. Riboflavin has been found to be particularly effective in preventing migraines. And it provides benefits through regular use rather than in the treatment of acute migraine. Migraine and Riboflavin, a natural and safe treatment option for chronic headaches, is beneficial for migraines. It can reduce the frequency and severity of attacks, especially those associated with mitochondrial dysfunction. It has been shown to be beneficial in some types of migraine. Riboflavin supplementation with magnesium and Combining it with other supplements such as coenzyme Q10 can be more effective in treating migraines. It can offer comprehensive support. Magnesium taurate and magnesium bisglycinate have positive effects on nerve health. These compounds prevent the overstimulation of nerve cells, thus providing relief. It can help reduce pain and migraines. Both forms are muscle relaxants. Its properties contribute to the alleviation of tension headaches. Magnesium taurate, By relaxing blood vessels, sudden throbbing of the arteries can be a trigger in some types of migraine. It can help prevent contractions. Magnesium supplements can also aid sleep. Improving its quality of life can indirectly help reduce headaches. Research and development efforts in these areas highlight the negative impacts of their shortcomings on human health. In order to reduce their effects, the relevant substances are combined with other supplements. Whether it will be effective using this method needs to be developed further. In conclusion, all the problems mentioned above necessitate innovation in the relevant field. It has brought it to this state. 3 THE PURPOSE OF THE INVENTION The present invention aims to eliminate the aforementioned problems and provide technical solutions in the relevant field. It is introduced with the aim of creating an innovation. The main purpose of the invention is to protect nerve cells by means of its neuroprotective properties. The goal is to provide support in reducing the severity and frequency of their pain. Another aim of the invention is to relax muscles while increasing blood flow through the effect of magnesium salts. by contributing to the dilation of blood vessels, it helps alleviate tension headaches. It is about providing support. DETAILED DESCRIPTION OF THE INVENTION This detailed description of the invention concerns a device for use in the treatment of headaches. Improved Magnesium Composition and Related Production Method is just one aspect of the subject. with examples that will not create any limiting effects so that it can be understood better It is explained. The subject of the invention is symptom relief for regular use in migraine and chronic headaches. by protecting nerve cells and helping to relax blood vessels Magnesium to help alleviate tension headaches. bisglycinate, magnesium taurate, coenzyme Q10, vitamin B2 and vitamin B12 content It relates to the use of a combination of its components as a food supplement. In its preferred configuration, the invention provides regular treatment for migraine and chronic headaches. In use, it aims to regulate symptoms, protect nerve cells, and promote blood flow. By helping to relax the blood vessels, it helps to relieve tension headaches. It is a food supplement composition designed to provide support, accordingly by weight;  Magnesium taurate in the range of 7.6899 – 61.1028%  Magnesium bisglycinate in the range of 7.9974 – 64.2256%  Coenzyme Q10 in the range of 9.4458 – 66.3565%  Vitamin B2 concentration range: 0.2428 – 55.5552%  Vitamin B12 (methylcobalamin) in the range of 0.0003 – 0.1237% It includes. 4 Composition components Daily Use Daily Use Minimum Dosage Maximum Dosage Magnesium Taurate 50 mg 175 mg Magnesium Bisglycinate 50 mg 200 mg Coenzyme Q10 60 mg 200 mg Vitamin B2 1.4 mg 200 mg Vitamin B12 (Methylcobalamin) 0.0025 mg 0.20 mg Table-1 Daily dosage range formulation for a preferred example of the invention. Table 1 shows the maximum and minimum preferred composition of the invention. The formulations are given. Daily dosage is based on the above components and the maximum dosage used. It includes minimum mg formulations. The final product obtained is a food supplement in the form of tablets, capsules, effervescent tablets, syrups, or drops. It comes in spray, sachet, softgel capsule, gummy and drcaps forms and is used for migraine and In accordance with the needs for relieving chronic headaches, and in line with health standards It has been prepared appropriately. Composition components by weight Daily weight Daily Minimum Usage Maximum Usage Percent Magnesium Taurate 7.6899% 61.1028% Magnesium Bisglycinate 7.9974% 64.2256% Coenzyme Q10 9.4458% 66.3565% Vitamin B2 0.2428% 55.5552% Vitamin B12 (Methylcobalamin) 0.0003% 0.1237% Table-2 Preferred formulation of the invention Table 2 shows the maximum and minimum weight values ​​of the preferred composition of the invention. Their structures are given. In alternative formulations of the invention, tablets or capsules containing the appropriate composition, effervescent tablets, syrups, drops, sprays, sachets, softgel capsules, gummies (chewable tablets), and Dr. Caps It is a dietary supplement in any of the following forms: (cellulose-based capsules). In alternative formulations of the invention, the dietary supplement in capsule form consists of 1 capsule. The dosage for this includes the following components;  Magnesium Taurate 50 mg  Magnesium Bisglycinate 65 mg  Coenzyme Q10 65 mg  Vitamin B2 65 mg  Vitamin B12 0.065 mg The invention is intended to be a symptom regulator with regular use in migraine and chronic headaches. It helps protect nerve cells and relaxes blood vessels, reducing tension. Production of food supplements to help alleviate certain types of headaches. It is a method related to this. Accordingly, the invention, a. Magnesium taurate, magnesium bisglycinate, and coenzyme Q10, vitamin B2, and vitamin B12 Vitamin active ingredients should be stored at a temperature range of 15-25°C and a humidity level of 30-60% RH. weighing and sifting within the specified range, The raw material mixture obtained in the first step of the process is transferred to the manufacturing boiler. and the manufacturing boiler at a temperature range of 15-25°C and a humidity range of 30-60% RH. and stirring for 1-5 minutes, c. Weighing and sieving of magnesium stearate to prevent clumping and manufacturing. added to the boiler and the mixture inside the manufacturing boiler is heated to 15-25°C. within a range of 30-60% RH humidity and for 2-5 minutes. mixing, The mixture obtained in the dc method step is stored at a temperature range of 15-25°C, with a concentration of 30-60%. Filling is done by transferring the capsules to the capsule filling machine within the RH humidity range. to be done, e. Making adjustments to the punch and capsule settings on the capsule filling machine and filling the capsules. The mixture is filled and stored at a temperature range of 15-25°C and a humidity range of 30-60% RH. Encapsulation within the specified range, f. Transferring the filled capsules to primary packaging. The method includes the steps. a. The weighing and sieving processes mentioned in method step a are used in pharmaceutical production and many other applications. It is involved in the initial stages of the formulation process. The purpose of these steps is to ensure the product... The goal is to ensure its quality and consistency. The weighing process ensures that the raw materials used in the formulation are measured in accurate quantities. This step directly affects the effectiveness and safety of the product, because each 6 The ratio of a component determines the overall performance and stability of the formula. Weighing The process is carried out using precision balances. These balances are used for very small quantities. It measures even the smallest particles with precision. The screening process removes clumps from powdered raw materials and... This is done to obtain a homogeneous mixture. Sieving involves passing the powders through a fine mesh. This is achieved by passing the powders through a filter. This process results in the powders becoming finer and more uniform. This ensures the right consistency, allowing them to mix more evenly in the production tank. Filtering also involves removing foreign substances and unwanted particles. It also helps to remove it from the formulation, which improves product quality. In the preferred configuration of the invention, magnesium taurate is used in step a. of the methodology. magnesium bisglycinate and coenzyme Q10, vitamin B2 and vitamin B12 are active ingredients. raw materials in the temperature range of 15-25°C and the humidity range of 30-60% RH. The weighing and sieving process is carried out. "RH" stands for "Relative Humidity". Humidity is the amount of water vapor in the air, the maximum amount of water the air can hold at that temperature. It expresses the ratio of the amount of steam to the total amount as a percentage. Because these processes are carried out at the beginning of the formulation, they affect all subsequent production stages. This is crucial for its success. Any mistakes or deviations in these early stages... If this occurs, it will negatively affect the quality of the entire batch of product, so these processes... It is being carried out in accordance with the procedure. In step b, the raw material mixture obtained in step a is used for manufacturing. and the material is placed in the boiler and manufactured in a boiler temperature range of 15-25°C and 30-60% RH humidity. The mixing process is carried out within a specific ratio and for a duration of 1-5 minutes. A suitable boiler is selected for manufacturing, and the necessary cleaning and sterilization processes are carried out. Mixing is a process that generally involves homogeneously mixing solid particles within a liquid. To ensure even distribution, to ensure that the solutes in a liquid are distributed homogeneously. to ensure dispersion or homogeneous mixing of different solid components It is a process carried out to ensure mixing. This process ensures the homogeneity of the mixture. This is done with the aim of increasing and ensuring an equal distribution among the components. The mixing process is carried out for a specific period of time and at a specific speed. In the preferred design of the invention, in step b, the raw material obtained. 7 the mixture is transferred to the manufacturing boiler and the manufacturing boiler is heated to a temperature range of 15-25°C. Mixing process at a humidity range of 30-60% RH for 1-5 minutes. This process involves ensuring that the raw material components are thoroughly integrated with each other. It ensures that a homogeneous mixture is formed. In the next method step, step c, we will prevent clumping. Weighing and sifting magnesium stearate, adding it to the manufacturing tank, and manufacturing... The mixture inside the boiler should be at a temperature range of 15-25°C and a humidity level of 30-60% RH. The mixing process takes place within a range of 2-5 minutes. The process aims to ensure the homogeneity of the mixture and the integration of the components. This means that it is carried out for a specified period of time and at a specific pace in order to provide support. Magnesium stearate is used as an anti-caking agent in powdered products. It is used to increase the fluidity of the products, thus ensuring a homogeneous mixture. It also prevents the dispersion of powdered products entering the mold and the powder It ensures that the products come out of the mold smoothly and evenly. In the next method step, step d, the results obtained in method step c are used. The mixture is filled into capsules at a temperature range of 15-25°C and a humidity range of 30-60% RH. The process involves transferring the contents to the machine and then filling them. During this process... the mixture is fed into the filling machine homogeneously and in specified quantities. Capsule filling machines are available as semi-automatic or fully automatic. It is positioned. Staple size is selected according to capsule size, and filling parameters are adjusted. Entry is made and the relevant filling is ensured. In the preferred configuration of the invention, d. In step c of the method, the mixture obtained in step c is at a temperature range of 15-25°C. Filling is done by transferring the capsules to the capsule filling machine within a humidity range of 30-60% RH. The process is being carried out. In the next method step, method step e, the punch and in the capsule filling machine... Capsule adjustments are made and the mixture is filled into the capsules at 15-25°C. encapsulation process within the temperature range and humidity range of 30-60% RH. is being carried out. The adjustments on the filling machine are made according to the type of capsule used. Capsule Adjustments are made according to their dimensions, shapes, and filling quantities. This ensures that the product is filled in the correct dosage and quality. Filling 8 The staples in the machine ensure that the capsules are properly sealed during the filling process. and ensures sealing. Correct positioning and adjustment of the staples, ensuring the capsules are filled securely and protected from external factors. This is ensured by staple and capsule adjustments, which increase the efficiency of the filling process. It ensures a faster and more orderly progress in the production process. The preferred invention In its structure, in step e of the process, the punch and capsule in the capsule filling machine. Adjustments are made and the mixture is filled into the capsules at a temperature of 15-25°C. Encapsulation is carried out within a humidity range of 30-60% RH. Capsules are usually filled using specially designed filling machines. To ensure the mixture is filled into the capsules in the correct amount, the filling machine must be pre-filled. It has defined dosage settings. This ensures the product is at the labeled dosage and quality. This process ensures that the product is in the correct quantities, of the correct quality, and in accordance with the procedure. By ensuring that the filling is done under these conditions, it improves product quality and reliability. In the next step of the method, step f, the information filled in step e is used. The capsules are transferred to primary packaging. The filled capsules are then placed in the packaging. The process step of transferring capsules to primary packaging is the final preparation of the product for end use. This is an important step in making it suitable. Depending on the type and characteristics of the product, the appropriate one will be chosen. Primary packaging materials are selected. These packages are airtight, protecting the product from the outside. It is designed to protect against harmful elements and to allow the product to be stored for a long time. It has the durability and protection to provide. These steps are the building blocks of the production process and have a direct impact on the quality of the final product. They are effective. Each step must be planned and implemented in accordance with the procedure. This ensures that the product is manufactured in accordance with the desired specifications and standards. The scope of protection of the invention is specified in the claims attached hereto, and these details are strictly adhered to. The explanation cannot be limited to those given for illustrative purposes. Because a technically skilled person... the person, without deviating from the main theme of the invention, in light of what has been described above, similar It is clear that these structures can emerge. 9

Claims

1. The invention relates to symptom regulation for regular use in migraine and chronic headaches. It helps protect nerve cells and relax blood vessels. to help alleviate tension headaches This is a method related to the production of food supplements, and its characteristics are as follows: A. Magnesium taurate, magnesium bisglycinate, coenzyme Q10, vitamin B2 and Vitamin B12 active ingredients are stored at a temperature range of 15-25°C, at a concentration of 30-60%. Weighing and sieving within the RH moisture content range, In the BA process step, the raw material mixture obtained is transferred to the manufacturing boiler. and manufacturing process in a boiler with a temperature range of 15-25°C and humidity of 30-60% RH. Mixing within the specified ratio range and for a duration of 1-5 minutes. C. To prevent clumping, magnesium stearate should be weighed and sieved. adding it to the manufacturing boiler and the mixture inside the manufacturing boiler being heated to 15-25°C within a temperature range, a humidity range of 30-60% RH, and for 2-5 minutes. mixing within the range, The mixture obtained in the DC method step is kept in the temperature range of 15-25°C. By transferring the capsules to the capsule filling machine within a humidity range of 30-60% RH. filling process E. Making adjustments to the punch and capsule settings on the capsule filling machine. The mixture is filled into capsules and stored at a temperature range of 15-25°C. Encapsulation should be carried out within a humidity range of 30-60% RH. F. Transferring filled capsules to primary packaging. It is characterized by including methodological steps.

2. The invention describes symptom relief for regular use in migraine and chronic headaches. It helps protect nerve cells and relax blood vessels. to help alleviate tension headaches It is a food supplement composition, characterized by its weight.  Magnesium taurate in the range of 7.6899 – 61.1028%  Magnesium bisglycinate in the range of 7.9974 – 64.2256%  Coenzyme Q10 in the range of 9.4458 – 66.3565%  Vitamin B2 concentration range: 0.2428 – 55.5552% 35  Vitamin B12 concentration in the range of 0.0003 – 0.1237% It is characterized by its inclusion.

3. The food supplement composition conforms to Claim 2, and its characteristic feature is that the daily dosage is... It includes the following components: Magnesium Taurate 50-175 mg Magnesium Bisglycinate 50-200 mg Coenzyme Q10 60-200 mg vitamin B2 1.4-200 mg o Vitamin B12 (Methylcobalamin) 0.0025-0.20 mg 4. Tablets or capsules containing the composition conforming to any of the requirements 2-3. effervescent, syrup, drops, spray, sachet, softgel capsule, gummy and drcaps (cellulose) It is a dietary supplement that comes in any of the following forms: capsule-based.

5. Complies with claim 4, and its characteristic is; a dietary supplement in capsule form, 1 capsule The dosage should include the following components:  Magnesium Taurate 50 mg  Magnesium Bisglycinate 65 mg  Coenzyme Q10 65 mg  Vitamin B2 65 mg  Vitamin B12 0.065 mg 11