Cognitive Function Support System with Biogel Containing Postbiotic and Neurotransmitter Precursor Suitable for Nasal Application.

Abstract

This invention relates to the application of Lactobacillus brevis postbiotic metabolites, glutamic acid, and neuropeptide in a hyaluronic acid-chitosan matrix in the form of a nasal biogel to support cognitive function. The system reduces mental fatigue and supports neurocognitive functions.

Description

Containing Postbiotic and Neurotransmitter Precursor Suitable for Nasal Application Biogel-Based Cognitive Function Support System Technical Area: This invention has implications for neurobiotechnology, postbiotic applications, and nasal biological delivery systems. It relates to the field. The aim is to deliver active ingredients that support cognitive function via the nasal route, close to the brain-brain barrier. It is targeted distribution. State of the Art: Oral supplements have low bioavailability in cases of brain fog and mental fatigue. Postbiotics are effective at the gut-brain axis, but nasal targeting is limited in the literature. Nasal gels are generally used solely for moisturizing purposes. Purpose of the Invention: A biogel containing postbiotic metabolites and neurotransmitter precursors that can be applied nasally. The goal is to improve and reduce brain fog, mental fatigue, and cognitive sluggishness. Summary of the Invention: • Source: Lactobacillus brevis postbiotic supernatant • Active ingredient: GABA precursor glutamic acid + short peptide neuromodulator • Matrix: hyaluronic acid + chitosan nasal gel • Effect: absorption from the nasal mucosa that indirect / immune neuroendocrine support to the central nervous system that cognitive performance ↑ that mental fatigue ↓ Application Example: 1. Lactobacillus brevis culture supernatant is filtered. 2. Glutamic acid is added at a rate of 0.1–0.3% w / v. 3. Short neuropeptide 20–100 μg / mL 4. Gel: HA 0.3% + chitosan 0.2% 5. Mouse cognitive tests (Y-maze): memory score increased by 22% those markers of mental fatigue ↓ synaptic protein expression ↑ Industrial Applicability: 35 Nasal nootropic biotechnology products, mental performance supplements, neuro-wellness therapeutics. 1

Claims

1. It is a cognitive function support system. Its characteristic feature is the presence of postbiotic metabolites derived from Lactobacillus brevis, along with glutamic acid and It is the stabilization of neuropeptide within a hyaluronic acid-chitosan nasal gel matrix.

2. Is it a system according to claim 1? Its defining characteristic is that the glutamic acid concentration is in the range of 0.05–0.3% w / v.

3. Is it a system according to claim 1? Its defining characteristic is that the neuropeptide concentration ranges from 20–100 μg / mL. 2