Single immunoglobulin domain bispecific antibodies against il-10r alpha and beta subunits and methods of use
TW202626731APending Publication Date: 2026-07-01GILEAD SCIENCES INC
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Patent Information
- Application Number
- TW114145454
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-11-22
- Filing Date
- 2025-11-21
- Publication Date
- 2026-07-01
Abstract
Provided are bispecific antibodies comprising first and second VHH binding domains that specifically bind to the extracellular domains of interleukin-10 receptor (IL-10R) alpha subunit (IL-10Rα) and beta subunit (IL-10Rβ), and that selectively suppress activation of myeloid cells and induce minimal or no direct activation of T cells or B cells.
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