Her2 binding immunoglobulin single variable domains, constructs comprising the same and uses thereof

Abstract

The present technology provides HER2-binding immunoglobulin single variable domains (ISVDs), polypeptides comprising such HER2-binding ISVDs, and polypeptide constructs comprising such HER2-binding ISVDs and an Fc region. The present technology further provides nucleic acids encoding said ISVDs, polypeptides, and polypeptide constructs as well as vectors, hosts and methods to produce these ISVDs, polypeptides, and polypeptide constructs. Moreover, the present technology relates to methods of treatment making use of the ISVDs, polypeptides or polypeptide constructs according to the present technology.