Oligonucleotide fragments and methods of making rnai agents using the same
TW202629226APending Publication Date: 2026-07-16ELI LILLY & CO
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Patent Information
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- ELI LILLY & CO
- Filing Date
- 2023-12-22
- Publication Date
- 2026-07-16
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Figure TWG2TA001069360_001 
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Abstract
Intermediate compounds (i.e., oligonucleotide fragments) are disclosed for making RNAi agents, or pharmaceutically acceptable salts thereof. In addition, methods are disclosed for making single-stranded oligonucleotides by ligating two or more of the intermediate compounds herein via a hybrid chemical-enzymatic route.
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