Compound for the sequestration of undesirable Anti-peg antibodies in a patient

Abstract

The present invention provides a compound for the sequestration of undesirable anti-polyethylene glycol (PEG) antibodies interfering with therapy by PEGylated active agents (such as PEGylated enzymes or antibodies) in a patient. The compound comprises an inert biopolymer scaffold and one or more PEG chains. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more anti-PEG antibodies present in an individual and a method of inhibiting an immune reaction to a treatment with ana PEGylated active agent.