Systems and methods for precision dose delivery, sterilization, and packaging of medical devices

Abstract

A drug delivery device that includes a body storing a VEGF antagonist, a plunger rod contacting a stopper inside the body, and a flange coupled to the body. The body is silicone-free. The plunger rod includes protrusions and the flange includes a proximal collar and slots positioned along the proximal collar. The flange is configured such that when the protrusions and slots are misaligned, distal movement of the plunger rod relative to the body is limited upon the protrusions contacting the proximal collar to prime the drug delivery device. The flange is configured such that when the protrusions and slots are aligned, distal movement of the plunger rod relative to the body is limited upon the protrusions extending into the slots to deliver the VEGF antagonist.