Anti-HIV-1 antibodies and uses thereof

Abstract

The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to HIV-1, e.g. CD4 binding site of HIV-1 env, and can neutralize HIV-1 infection. Also provided are polynucleotides that encode an antibody, vectors that comprise such polynucleotides, host cells that can express the antibodies, related compositions, and methods of using the herein disclosed compositions to, for example, treat or prevent an HIV-1 infection.