uPA peptide-imprinted conductive polymer, biosensor, and its preparation method effectively applied to the detection of uPA in human serum samples by means of extended gate field-effect transistor (EG-FET) sensing or electrochemical sensing

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A peptide-imprinted conductive polymer biosensor addresses the limitations of existing uPA detection methods by providing rapid, accurate, and cost-effective uPA concentration measurement, suitable for home healthcare applications.

TW202630001AActive Publication Date: 2026-07-16NATIONAL UNIVERSITY OF KAOHSIUNG

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Patent Information

Application Number: TW114100260
Authority / Receiving Office: TW · TW
Patent Type: Applications
Current Assignee / Owner
Filing Date: 2025-01-03
Publication Date: 2026-07-16
Estimated Expiration: 2045-01-02

Application Information

Patent Timeline

03 Jan 2025

Application

TW114100260

16 Jul 2026

Publication

TW202630001A

IPC: G01N27/26; G01N33/50

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Application Domain

Biological testing Material electrochemical variables

Technology Topics

Serum samples Small peptide

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AI Technical Summary

Technical Problem

Existing methods for detecting uPA concentration in samples are limited by high costs, complex procedures, low accuracy, and high labor requirements, making them unsuitable for widespread adoption and home healthcare applications.

Method used

A peptide-imprinted conductive polymer biosensor utilizing a conductive polymer monomer and a peptide template of specific amino acid composition is developed for uPA detection, enabling high sensitivity, low cost, and portability.

Benefits of technology

The biosensor achieves rapid, accurate, and cost-effective detection of uPA concentrations, suitable for home healthcare, with improved specificity and reduced detection limits, facilitating timely treatment of thrombotic diseases.

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Abstract

The present invention relates to a uPA peptide-imprinted conductive polymer and its preparation method, particularly to a peptide-imprinted conductive polymer containing a monomer of a conductive polymer and a small peptide portion of the uPA molecule as a template. The uPA peptide-imprinted conductive polymer provided by the present invention exhibits advantages of high sensitivity, high accuracy, rapid analysis, small sample volume required, reusability, high chemical stability, simple preparation process, low cost, portability, and low detection limit. It can be effectively applied to the detection of uPA in human serum samples by means of extended gate field-effect transistor (EG-FET) sensing or electrochemical sensing.

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