Anti-aging compositions and their use in promoting telomere elongation

Abstract

This invention discloses an anti-aging composition and its use in promoting telomere elongation. The anti-aging composition comprises at least one microalgae extract, one ramie complex extract, one amla extract, one buckwheat complex extract, and one salmon extract. Because the anti-aging composition disclosed in this invention has the activity of elongating telomere length, administering an effective amount of the anti-aging composition to an individual can achieve the effects of slowing down aging and preventing age-related diseases.

Description

Technical Field

[0001] This invention relates to a composition and its use, particularly to an anti-aging composition and its use in promoting telomere elongation. Prior Technology

[0002] Note that telomeres are structures at the ends of human chromosomes, primarily functioning to protect gene stability and are associated with aging and lifespan. Recent studies have indicated a correlation between telomere length and lifespan, as well as the occurrence of age-related diseases. This means that shortened telomeres reduce their protective effect on chromosomes, leading to an increased risk of cardiovascular disease, diabetes, neurodegenerative diseases, cancer, and ultimately, increased mortality.

[0003] Telomere length is affected by external factors; for example, increased stress causes telomere shortening, while the length increases after stress is removed. Intracellular telomerase maintains telomere length and prevents shortening, meaning that increased telomerase activity slows down telomere shortening, thus reducing the rate of aging and the risk of disease. Studies indicate that telomerase activity increases due to a healthy diet and / or exercise. Summary of the Invention

[0004] The main objective of this invention is to provide an anti-aging composition and its use in promoting telomere elongation. This composition can enhance telomerase activity by taking or supplementing with natural extracts, thereby slowing down the rate of telomere shortening or increasing telomere length, thus achieving anti-aging and prevention of age-related diseases.

[0005] Therefore, to achieve the above objectives, this invention discloses an anti-aging composition and its use in promoting telomere elongation. The anti-aging composition mainly comprises various plant extracts, such as microalgae extract, ramie complex extract, amla extract, buckwheat complex extract, and salmon extract. Because this anti-aging composition has the activity of elongating telomere length and reducing telomere age, administering an effective amount of this anti-aging composition to an individual can effectively maintain physical strength, slow down the aging process, and reduce the risk of developing age-related diseases.

[0006] In the anti-aging composition disclosed in this invention, the weight of the microalgae extract is approximately 1.7-2 times the weight of the buckwheat compound extract; the weight of the ramie compound extract is approximately 1.2-1.5 times the weight of the buckwheat compound extract; the weight of the amla extract is approximately 1-1.2 times the weight of the buckwheat compound extract; and the weight of the salmon extract is approximately 0.05-0.1 times the weight of the buckwheat compound extract.

[0007] In one embodiment of the present invention, the anti-aging composition further comprises a multivitamin, the multivitamin being approximately 0.05-0.1 times the weight of the buckwheat complex extract.

[0008] Furthermore, in the anti-aging composition disclosed in this invention, the weight ratio of the microalgae extract, the ramie complex extract, the amla extract, the buckwheat complex extract, the multivitamin, and the salmon extract is: 1.7-2:1.3-1.5:1.3-1.5:1:0.05-0.1:0.05-0.1.

[0009] The ramie compound extract comprises a ramie root extract and an astragalus extract. Both the ramie root extract and the astragalus extract are aqueous extracts.

[0010] The buckwheat compound extract comprises a buckwheat extract, a green tea extract, a golden pine mushroom extract, and a yeast ferment. Specifically, the buckwheat extract is obtained by extracting buckwheat using water as the extraction solvent; the green tea extract is obtained by extracting green tea using water as the extraction solvent; and the golden pine mushroom extract is obtained by extracting golden pine mushroom using water as the extraction solvent.

[0011] The salmon extract is derived from salmon nasal cartilage and mainly contains type II collagen, chondroitin, and peptides with a content of less than 500 Da.

[0012] The amla extract was obtained by extracting amla fruit with sodium chloride aqueous solution at 65-75°C.

[0013] The microalgae extract is derived from a marine microalga and mainly contains 10-35% Omega-3 fatty acids.

[0014] In a further embodiment of the present invention, the anti-aging composition can be used as a composition for extending telomere length. Simple Explanation of the Diagram

[0015] Figure 1 shows the results of detecting posterior granular length in the control and experimental groups before and after the experiment. Figure 2 shows the results of detecting posterior granulomatous age in the control and experimental groups before and after the experiment. Figure 3 shows the results of detecting the posterior granular length of the subjects in the experimental group before and after the experiment. Figure 4 shows the results of detecting the posterior granulation age of the subjects in the experimental group before and after the experiment. Figure 5 shows the comparison between the actual age of the subjects in the experimental group and their telogen effluvium age after the experiment. Implementation

[0016] This invention discloses an anti-aging composition and its use in promoting telomere elongation. The anti-aging composition comprises at least one microalgae extract, one ramie complex extract, one amla extract, one buckwheat complex extract, and one salmon extract. By administering an effective amount of the anti-aging composition to an individual, it is possible to effectively increase the length of the individual's telomeres, thereby achieving the effects of slowing down aging and rejuvenating.

[0017] In one embodiment of the present invention, the weight of the microalgae extract is approximately 1.7-2 times the weight of the buckwheat compound extract; the weight of the ramie compound extract is approximately 1.2-1.5 times the weight of the buckwheat compound extract; the weight of the amla extract is approximately 1-1.2 times the weight of the buckwheat compound extract; and the weight of the salmon extract is approximately 0.05-0.1 times the weight of the buckwheat compound extract.

[0018] In one embodiment of the present invention, the anti-aging composition further comprises a multivitamin. The multivitamin weighs approximately 0.05-0.1 times the weight of the buckwheat complex extract.

[0019] Specifically, the anti-aging composition disclosed in this invention comprises the microalgae extract, the ramie complex extract, the amla extract, the buckwheat complex extract, the multivitamin, and the salmon extract, and the weight ratio of the above components in the anti-aging composition is 1.7-2:1.3-10.5:1.3-1.5:1:0.05-0.1:0.05-0.1.

[0020] Furthermore, the anti-aging composition is a food or a nutritional supplement, and can be prepared into different dosage forms, such as powder, tablets, capsules, jelly, etc., depending on the needs.

[0021] In the embodiments disclosed in this invention, the microalgae extract is extracted from a marine microalga. Specifically, the microalgae extract is algal oil obtained by supercritical fluid extraction of the marine microalgae, which contains 10-35% Omega-3 fatty acids. To improve the convenience of use, it can be further prepared into water-soluble algal oil powder using flow granulation.

[0022] The ramie compound extract disclosed in this invention comprises a ramie root extract and an astragalus extract. Specifically, the preparation method of the ramie compound extract is as follows: the whole ramie root plant and astragalus are separately concentrated and extracted with pure water, then filtered to obtain ramie root extract and astragalus extract; the ramie root extract and astragalus extract are mixed in a predetermined weight ratio, and then concentrated and dried to obtain the brown powder of the ramie compound extract; wherein, the ramie root extract and the astragalus extract are mixed in a weight ratio of 1:0.01-1, and it is preferable that the ramie root extract and the astragalus extract are mixed in an equal weight ratio or nearly equal weight.

[0023] The amla extract disclosed in this invention is extracted from the fruit of *Emblica officinalis*. The amla extract is prepared by the following steps: first, amla fruit is soaked in an aqueous sodium chloride solution, then heated in a steam bath at 65-75°C for 1 hour, followed by filtration; the filtrate is frozen and then dried to obtain the amla extract in the form of a brown powder.

[0024] The buckwheat compound extract disclosed in this invention is composed of a buckwheat extract, a green tea extract, a golden pine mushroom extract, and a yeast ferment. The buckwheat compound extract is prepared by the following steps: buckwheat, green tea leaves, and golden pine mushroom are extracted separately with pure water, and the filtrates are collected; the three filtrates are mixed in a predetermined weight ratio and then concentrated to obtain a concentrate; liquid yeast ferment is added to the concentrate, and then freeze-dried to obtain a brown powdery buckwheat compound extract; wherein the buckwheat extract, green tea extract, and golden pine mushroom extract are mixed in a weight ratio of 1:0.01-1:0.01-1, preferably with each component mixed in equal or nearly equal weights; and the amount of yeast ferment added is 0.01-1 times the weight of the buckwheat extract.

[0025] The salmon extract disclosed in this invention is derived from salmon nasal cartilage and is rich in type II collagen, chondroitin, and peptides with a content of less than 500 Da.

[0026] The term "marine microalgae" refers to microalgae that exist in the ocean. They have different species and names depending on their origin, such as Nannochloropsis sp. and Schizochytrium sp.

[0027] The term "ramie" refers to a perennial herbaceous shrub that grows to a height of 1-2 meters and is native to Asia.

[0028] The term "emulsifiable concentrate" (Phyllanthus Emblica or Emblica Officinale), also known as amla, amla fruit, oil orange, amalaka, Pokok Melaka, and Indian gooseberry, is a deciduous sub-tree of the genus Emblica in the family Euphorbiaceae. It is distributed from India to Malaysia and southern China, and is generally considered to be native to India.

[0029] The term "multivitamin" refers to a product containing vitamins necessary for maintaining life, typically containing at least two of vitamins A, B, C, D, E, and K. Currently, in the technical field to which this invention pertains, this ingredient is purchased from the market.

[0030] Furthermore, in order to illustrate the technical features of the present invention and the effects it can achieve, several examples will be given below in conjunction with drawings for detailed explanation.

[0031] We recruit participants who are 35 years of age or older and have no specific diseases. The participants are not gender-specific. Specific diseases are such as cancer or other diseases that are not clinically recognized as common in the age group to which the participants belong.

[0032] Subjects were randomly divided into two groups: a control group and an experimental group, with a trial period of one month. Before the trial, blood samples were drawn from each group to measure telomere length and telomere age. During the trial, the dietary and lifestyle habits of the subjects in each group were not changed. Subjects in the experimental group were instructed to take one capsule of the anti-aging composition disclosed in this invention each morning and at noon. This anti-aging composition contains microalgae extract, ramie compound extract, amla extract, buckwheat compound extract, multivitamins, and salmon extract, with a weight ratio of approximately 1.7-2:1.3-10.5:1.3-1.5:1:0.05-0.1:0.05-0.1, and each capsule contains 500mg. Subjects in the control group took one placebo (500mg, with starch as the main component) each morning and at noon. After the trial, blood samples were drawn from each group again for analysis of telomere length and telomere age. The above-mentioned detection methods are all well known to those skilled in the art and therefore will not be elaborated upon here.

[0033] The telomere length and telomere age of the control group and the experimental group before and after the experiment were compared, and the results are shown in Figures 1 and 2. Furthermore, the differences in telomere length, telomere age, and the relationship between telomere age and actual age before and after the experiment in the experimental group were analyzed, and the results are shown in Figures 3 to 5. The relevant data are shown in Table 1 below.

[0034] Table 1: Test Results control group experimental group Testing items 0 months (before the trial) One month (after the trial) 0 months (before the trial) One month (after the trial) Average telomere length (Kb) 8.3 8.5 8.3 10.4 Average telomere detection rejuvenation age 59 59 59.4 43.3 Average Actual Age vs. Telomere Detection Age 42 43.5 42 30.5

[0035] The results shown in Figures 1 to 5 indicate that there was no difference in telomere length and age before and after the experiment in subjects who did not take the anti-aging composition disclosed in this invention. However, the telomere length of subjects in the experimental group who took the anti-aging composition disclosed in this invention for one month was increased compared to that of the control group, and the telomere age of the experimental group was significantly reduced compared to before the experiment or the control group. The comparison results of the experimental group before and after the experiment show that after taking the anti-aging composition disclosed in this invention, the telomere length of the subjects increased by 22.35% compared to before the experiment, the telomere age decreased by 26.61% compared to before the experiment, and the telomere age decreased by approximately 30% compared to their actual age.

[0036] The results above show that the anti-aging composition disclosed in this invention can indeed prolong telomere length and reduce telomere age. That is, by administering an effective amount of the anti-aging composition disclosed in this invention to an individual, it is possible to delay individual aging, prevent the occurrence of age-related diseases, and maintain individual physical strength.

[0037] none

Claims

1. An anti-aging composition comprising a microalgae extract, a ramie compound extract, an amla extract, a buckwheat compound extract, and a salmon extract; wherein the weight of the microalgae extract is approximately 1.7-2 times the weight of the buckwheat compound extract; the weight of the ramie compound extract is approximately 1.2-1.5 times the weight of the buckwheat compound extract; the weight of the amla extract is approximately 1-1.2 times the weight of the buckwheat compound extract; and the weight of the salmon extract is approximately 0.05-0.1 times the weight of the buckwheat compound extract; wherein: The microalgae extract is algal oil obtained by supercritical extraction of a marine microalga, containing 10-35% Omega-3 fatty acids; the ramie compound extract is obtained by mixing a ramie root extract and an astragalus extract in a weight ratio of 1:0.01-1, wherein the ramie root extract and the astragalus extract are obtained by concentrating and extracting a ramie root and an astragalus extract respectively using pure water as the extraction solvent; the amla extract is the filtrate obtained by soaking amla fruit in a sodium chloride aqueous solution and heating it at 65-75°C. The buckwheat compound extract is composed of buckwheat extract, green tea extract, golden oyster mushroom extract, and yeast fermentation product. The buckwheat extract, green tea extract, and golden oyster mushroom extract are mixed in a weight ratio of 1:0.01-1:0.01-1. The buckwheat extract, green tea extract, and golden oyster mushroom extract are obtained by extracting buckwheat, green tea, and golden oyster mushroom separately using water as the extraction solvent. The salmon extract is extracted from salmon nasal cartilage and is rich in type II collagen, chondroitin, and peptides with a content of less than 500 Da.

2. The anti-aging composition as claimed in claim 1, further comprising a multivitamin, wherein the multivitamin is approximately 0.05-0.1 times the weight of the buckwheat complex extract.

3. Use of an anti-aging composition as described in claim 1 or 2 for preparing a composition for extending telomere length.

Images