Methods for the continuous preparation of antibody conjugates

Abstract

This invention relates to a method for the continuous preparation of antibody-drug conjugates, comprising: 1) providing an unpurified or partially purified antibody or its antigen-binding fragment thereof; 2) conjugating the unpurified or partially purified antibody or its antigen-binding fragment thereof to a payload via a linker to prepare an antibody-drug conjugate; and 3) purifying the antibody-drug conjugate. The method of this invention simplifies the process, significantly shortens the production cycle, reduces reagent consumption, and is both efficient and economical.

Images