ITGβ6 antibody and its uses

Abstract

This invention belongs to the field of biomedicine, specifically relating to an ITGβ6 antibody and its uses. The antibody or its antigen-binding fragment of this invention can specifically recognize / bind to ITGβ6, but does not bind to ITGβ1, ITGβ3, ITGβ5, ITGβ8, ITGαV, αVβ1, αVβ3, αVβ5 and / or αVβ8, exhibiting good endocytic activity. Furthermore, the FcγR binding function of this antibody or its antigen-binding fragment is removed, lacking ADCC and / or CDC activity, effectively avoiding side effects caused by ADCC and / or CDC function. This antibody does not bind to Fc receptors CD16a, CD32a, and CD64 proteins, reducing Fc receptor-mediated non-specific killing and improving drug safety, while retaining FcRn protein binding activity without affecting the drug's half-life.

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