Compositions of engineered cytokine expressing cells and methods of use thereof

Abstract

Provided herein is an immune cell expressing a recombinant IL-2 or IL-2 mutein, wherein the immune cell is a natural killer cells (e.g., a cord blood derived NK (CB-NK) cell) or a γδ T cell, and wherein the IL-2 mutein has reduced binding to IL2 receptor (IL2R) (e.g., IL2Rβ). These immune cells can also be used in conjunction with cells genetically engineered with chimeric antigen receptors (CARs). Also provided are methods of modulating immune function by administering said immune cell, and methods of treating cancer, for example, acute myeloid leukemia.

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