Methods and compositions for treating TNNT2 related cardiomyopathy or symptoms thereof

Abstract

The present disclosure relates to compositions and methods for the treatment of cardiomyopathy. Some embodiments provided for herein relate to virally-mediated transfer of a gene to host cells to induce expression of an encoded polypeptide, protein or other product for use in ameliorating one or more symptoms of the cardiomyopathy. In some embodiments, the methods and compositions relate to recombinant adeno-associated virus particles encoding human TNNT2 in order to treat cardiomyopathies, including dilated cardiomyopathy or hypertrophic cardiomyopathy.

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