Antibody-drug complexes (ADCs) containing VLK peptide linkers, and pharmaceutical compositions containing such ADCs.
TW202637221APending Publication Date: 2026-09-16CAST BIO INC
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Patent Information
- Application Number
- TW114146386
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-11-27
- Filing Date
- 2025-11-27
- Publication Date
- 2026-09-16
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Abstract
This disclosure provides an ADC containing a plasma cleavage site. The ADC disclosed herein may be hydrophobic between the antibody and the plasma cleavage site, for example, it does not contain non-charge-dependent hydrophilic polymers such as polyethylene glycol (PEG).
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