Glypican-3 targeting compositions and uses thereof

Abstract

Provided herein are GPC-3 binding peptides and non-radionuclide conjugates thereof, and compositions comprising the same. The GPC-3 targeting peptides and non-radionuclide conjugates thereof have avidity to GPC3. The GPC-3 targeting peptides described herein can optionally further comprise a linker connecting the GPC-3 targeting peptide to a non-radionuclide moiety. The non-radionuclide conjugates described herein comprises the GPC-3 targeting peptide linked to a non-radionuclide moiety, either directly or through a linker. Further provided herein are methods of diagnosing and / or treating a disease or condition characterized by GPC-3 expression (e.g., overexpression), such as various cancers, by administering the described peptides and non-radionuclide conjugates thereof, or compositions thereof.

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