Treatment of previously treated subjects having colorectal cancer using an Anti-EGFR rechallenge treatment with a bispecific antibody that binds EGFR and LGR5

Abstract

The disclosure relates to means and methods in the treatment of a subject having a colorectal cancer. The disclosure in particular relates to therapeutic uses and methods involving a bispecific antibody that binds EGFR and LGR5. Such bispecific antibody is particularly useful in the treatment of metastatic colorectal cancer or a locally advanced, unresectable colorectal cancer. The disclosure further relates to uses in such methods and to the use in the manufacture of a medicament for the treatment of such cancers.

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