Method of ultrasound microbubble-assisted liquid biopsy

Abstract

A method for ultrasound microbubble-assisted liquid biopsy is provided, including: providing an individual to be tested; providing a microbubble composition, in which the microbubble composition includes a medium and a plurality of microbubbles dispersed in the medium; placing the microbubble composition on a surface of the individual to be tested; contacting the microbubble composition with an ultrasonic device, and applying non-focused ultrasound to the microbubble composition to raise the surface temperature by no more than 3°C; and placing an absorbent substrate on the surface of the individual to be tested and absorbing a liquid located inside the individual to be tested, thereby achieving a non-invasive liquid biopsy, wherein the absorbent substrate contains no protein components, and the absorption and subsequent release effect is greater than

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