Photostabilized and / or viscosity-stabilized atropine-containing aqueous pharmaceutical composition

Abstract

This invention provides an ophthalmic pharmaceutical preparation and its light stabilization method and / or viscosity reduction prevention method. The ophthalmic pharmaceutical preparation is an aqueous pharmaceutical composition contained in a direct package that is visible internally and blocks light of a specific wavelength. The aqueous pharmaceutical composition contains 0.001 to 0.1% (w / v) of atropine or its salt and a thickener, and achieves light stabilization and / or prevents viscosity reduction. The thickener is at least one selected from the group consisting of hydroxyethyl cellulose (HEC), hydroxypropyl methylcellulose (HPMC), and sodium carboxymethyl cellulose (CMCNa). The specific wavelength is (i) 210 to 380 nm when the thickener is hydroxyethyl cellulose and / or hydroxypropyl methylcellulose, or (ii) 210 to 410 nm when the thickener contains sodium carboxymethyl cellulose.

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