Pharmaceutical ingredients for eye diseases

Abstract

Pharmaceutical compositions are provided for the prevention and / or treatment of eye diseases associated with the formation or accumulation of metabolic waste products within, on, and / or under retinal pigment epithelial (RPE) cells. These pharmaceutical compositions utilize an antibody or its antigen-binding fragment specifically binding to MerTK as an active ingredient. According to the aforementioned pharmaceutical compositions, the formation or accumulation of metabolic waste products within, on, and / or under RPE cells can be inhibited, contributing to the prevention and / or treatment of eye diseases associated with the formation or accumulation of metabolic waste products. According to the aforementioned pharmaceutical compositions of the present invention, the formation or accumulation of metabolic waste products due to incomplete digestion within RPE cells can be inhibited. According to the aforementioned pharmaceutical compositions of the present invention, the formation or accumulation of metabolic waste products selected from one or more of crypts, crypt-like pigment epithelial detachment, subretinal deposits, lipofuscin, melanin lipofuscin, extracellular matrix, and fibrous material within, on, and / or under RPE cells can be inhibited, contributing to the prevention and / or treatment of eye diseases.

Images