Pulse stimulator for cell ablation
Patent Information
- Application Number
- TW114109908
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2025-03-17
- Publication Date
- 2026-10-01
- Estimated Expiration
- 2045-03-16
Smart Images
Figure TWG2TA001077490_001 
Figure TWG2TA001077490_002 
Figure TWG2TA001077490_003
Abstract
Claims
1. A pulse stimulation device for ablating cells, comprising: a generator configured to deliver an electrical pulse to at least one electrode, the electrical pulse comprising: a positive voltage, a negative voltage, or a combination thereof based on a resting membrane potential, or a positive power, a negative power, or a combination thereof based on an extramembrane potential, wherein the extramembrane potential is 0 volts, wherein... The transmission frequency of the electrical pulse includes at least one pulse duration and at least one pulse pause time, wherein the at least one pulse duration is between 2 seconds and 60 seconds, and the at least one pulse pause time is between 15 seconds and 300 seconds; and wherein the electrical pulse is configured to non-thermally ablate a plurality of cells in a target area.
2. The pulse stimulation device as claimed in claim 1, wherein the positive power based on the extramembrane potential includes a range from greater than 0 microwatts to 100 microwatts, and the negative power based on the extramembrane potential includes a range from less than 0 microwatts to -100 microwatts.
3. The pulse stimulation device as claimed in claim 1, wherein the positive voltage based on the resting membrane potential includes a range from greater than 0 millivolts to 70 millivolts, and the negative voltage based on the resting membrane potential includes a range from less than 0 millivolts to -70 millivolts.
4. The pulse stimulation device as claimed in claim 1, wherein a maximum current limit of the electrical pulse includes a range of -1 milliampere to 1 milliampere.
5. The pulse stimulation device as claimed in claim 1, wherein the electrical pulse comprises: a unidirectional electrical pulse comprising: the positive power or the negative power based on the extramembrane potential, or the positive voltage or the negative voltage based on the quiescent membrane potential; or a bidirectional electrical pulse comprising: the positive power and the negative power based on the extramembrane potential, or the positive voltage and the negative voltage based on the quiescent membrane potential.
6. The pulse stimulation device as claimed in claim 5, wherein the bidirectional electrical pulse comprises a bidirectional asymmetric electrical pulse, and the transmission frequency of the electrical pulse further comprises at least one pulse duration and at least one pulse pause time, the at least one pulse duration and the at least one pulse pause time being different.
7. The pulse stimulation device as claimed in claim 6, wherein the duration of the at least one pulse is between 2 seconds and 60 seconds, and the pause time of the at least one pulse is between 15 seconds and 300 seconds.
8. The pulse stimulation device as claimed in claim 7, wherein the number of the at least one pulse duration is two pulse durations, the number of the at least one pulse pause time is two pulse pause times, and the pulse durations and the pulse pause times are arranged sequentially at intervals.
9. The pulse stimulation device as claimed in claim 5, wherein the bidirectional electrical pulse further comprises: the positive power followed by the negative power, or the negative power followed by the positive power; or the positive voltage followed by the negative voltage, or the negative voltage followed by the positive voltage.
10. The pulse stimulation device as claimed in claim 1, wherein the number of the at least one pulse duration is two pulse durations, the number of the at least one pulse pause time is two pulse pause times, and the pulse durations and the pulse pause times are arranged sequentially at intervals.
11. The pulse stimulation device as claimed in claim 1, wherein the number of electrical pulses is from 1 to 30.
12. The pulse stimulation device as claimed in claim 1, wherein the cells in the target region are depolarized based on the positive voltage of the resting membrane potential or the positive power based on the extramembrane potential, and wherein the cells in the target region are overpolarized based on the negative voltage of the resting membrane potential or the negative power based on the extramembrane potential.
13. The pulse stimulation device as claimed in claim 1, wherein a waveform of the electrical pulse includes square, trapezoidal, spiked, flat, or a combination thereof.
14. The pulse stimulation device as claimed in claim 1 further comprises: a flexible conduit, a proximal end of which is connected to the generator; and an electrode assembly including at least one electrode disposed at a distal end of the flexible conduit and electrically connected to the generator.
15. The pulse stimulation device as claimed in claim 14, wherein the number of the at least one electrode is a plurality of electrodes, the electrodes comprising bipolar electrodes or tripolar electrodes.
16. The pulse stimulation device as claimed in claim 14, wherein the generator comprises: a power supply unit including: a drive circuit block configured to generate, pause, or stop a signal of power, voltage, or current; and a power module electrically connected to the drive circuit block and configured to control the output of the signal to the electrode assembly; and a control unit electrically connected to the drive circuit block and configured to control the generation and cessation of the output signal in the drive circuit block.