Radiopharmaceutical compositions targeting glypican-3 and uses thereof

Abstract

Provided herein are radiopharmaceuticals and conjugates, and compositions thereof, targeting glypican-3 (GPC3), and uses thereof. In one aspect, provided herein are conjugates that comprise a peptide with avidity to GPC3 and a metal chelator configured to bind with a radionuclide. The conjugates described herein can further comprise a linker connecting the chelator and the peptide. The conjugates described herein can further comprise a radionuclide. In one aspect, provided herein are radiopharmaceuticals that comprise a peptide and a metal chelator bound to a radionuclide. The conjugates described herein can further comprise a linker connecting the chelator and the peptide. Further provided herein are methods of treating cancer by administering the described radiopharmaceuticals, conjugates, compositions thereof.

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