Tumor-activated cell engagers and methods of use thereof

Abstract

The present invention relates to tumor-activated cell engagers, comprising a first targeting moiety that binds to a tumor associated antigen, a second targeting moiety that binds to an immune cell (e.g., a T-cell), a Fc region, a cell binder masking moiety, and a protease cleavage site. The first target moiety binds to a tumor cell and the second targeting moiety binds to a cytotoxic cell e.g., a T-cell thereby bringing them in proximity for enhanced cytotoxic effect to tumor cells. The cell binder masking moiety masks the second targeting moiety (T-cell binder) and cleavage of the protease cleavage site in a tumor environment activates the binding of the second targeting moiety to the cell.

Images