β-glucocerebrosidase enzymes, fusion proteins and complexes comprising the same, and methods of use thereof
TW202639849APending Publication Date: 2026-10-01ALECTOR LLC
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Patent Information
- Application Number
- TW114149215
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2025-12-09
- Filing Date
- 2025-12-15
- Publication Date
- 2026-10-01
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Figure TWG2TA001078809_001 
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Abstract
The present disclosure is generally directed GCase polypeptides as well as fusion proteins and complexes comprising a GCase polypeptide and an antigen-binding domain that specifically binds to blood-brain barrier (BBB) target such as human transferrin receptor (TfR) or human CD98 heavy chain (CD98hc). Such fusion proteins and complexes can transport the GCase polypeptide across BBB, e.g. for treatment of GCase deficiencies in the central nervous system.
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