Transgenic animals expressing heavy chain antibodies

TW202641402APending Publication Date: 2026-10-16KISOJI BIOTECHNOLOGY INC
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Patent Information

Application Number
TW114148944
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2020-09-09
Filing Date
2021-07-13
Publication Date
2026-10-16

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Abstract

The present disclosure generally relates to transgenic animals comprising germline modifications at an immunoglobulin heavy chain (IgH) locus for expressing heavy chain antibodies (HCAbs) as well as nucleic acid constructs, cells and methods for generating same. The present disclosure also relates to binding agents comprising sequences derived from the heavy chain antibodies produced by the transgenic animals.
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