High-drug-loading molecular simvastatin ointment, its preparation and application

Abstract

This invention relates to a high-drug-loading molecular simvastatin ointment for skin and its preparation process. The ointment consists of simvastatin and a basic matrix composition. The basic matrix composition includes a basic matrix, solubilizers, consistency modifiers, and stabilizers. In this ointment, simvastatin is stably present in molecular form within the basic matrix composition. Phospholipids and cholesterol, acting as solubilizers and stabilizers, self-assemble in a non-aqueous solution to form a reverse micelle structure, enhancing drug stability. Simultaneously, the reverse micelle system increases the solubility of the weakly polar drug, significantly increasing skin retention when used as a transdermal drug delivery carrier, thus enhancing transdermal drug absorption.

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