Bis-heteroaryl amide compounds and uses thereof

Abstract

Provided herein are compounds, including compounds of any of the formulae described herein (e.g., Formula (I)), and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, hydrates, isotopically labeled derivatives, and prodrugs thereof. Compounds provided herein can potentiate Kv7 potassium channels (e.g., Kv7.2 / Kv7.3). In some embodiments, the compounds provided herein are useful in the treatment and / or prevention of diseases, disorders, and conditions (e.g., diseases, disorders, and conditions associated with Kv7 potassium channel dysfunction). In some embodiments, the compounds provided herein target Kv7 voltage-sensing domains (VSDs).