Amorphous obicetrapib solids including dispersions of obicetrapib and obicetrapib salts

Abstract

The disclosure is directed to solid forms of obicetrapib and amorphous solid dispersions comprising one or more of amorphous obicetrapib hemicalcium, amorphous obicetrapib free acid and / or obicetrapib alkali salts, one or more dispersion excipients, and optionally one or more surfactants. Further provided herein are methods of preparing such solid forms of obicetrapib and amorphous solid dispersions of obicetrapib and the solid forms and amorphous dispersions so prepared. The disclosure further provides pharmaceutical compositions comprising such solid forms of obicetrapib and / or amorphous solid dispersions of obicetrapib. Also included within the disclosure are methods of treating subjects in need thereof with such solid forms of obicetrapib and / or amorphous solid dispersions or pharmaceutical compositions of the disclosure.

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