CBP / p300 heterobifunctional conditional inhibitors

Abstract

Described herein are heterobifunctional small molecules, methods of making, pharmaceutical compositions and medicaments comprising such heterobifunctional small molecules, and methods of using such heterobifunctional small molecules are described herein, in the conditional inhibition of the activity of CREB-binding protein (CBP) / p300 in cells expressing the androgen receptor.

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