A degrader targeting pan-KRAS protein and its uses

Abstract

This invention belongs to the field of pharmaceutical technology, specifically relating to a compound targeting KRAS protein degraders and its uses. This invention provides a compound having an FLM structure, or its tautomer, racemate, enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt thereof, wherein F is a KRAS protein binding fragment; L is a linker unit connecting F and M; and M is a VHL binding fragment. The compound of this invention can be used to treat diseases caused by KRAS mutations or amplifications.

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