Novel hydrophilic linkers and their drug linkers, protein-conjugated drugs, pharmaceutical compositions and uses

Abstract

This disclosure pertains to the field of biomedicine and relates to novel hydrophilic linkers and drug linkers thereof, protein-conjugated drugs, pharmaceutical compositions, and uses. Specifically, this disclosure provides a drug linker comprising a novel hydrophilic group (e.g., the drug linker shown in Formula II), a protein-conjugated drug based on the drug linker, a pharmaceutical composition comprising the protein-conjugated drug, and its use in treating related diseases (e.g., cancer).

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