A T-cell receptor and its application

Abstract

This invention relates to the field of cancer immunotherapy. Specifically, this application relates in some aspects to binding molecules, such as complexes capable of specifically binding major histocompatibility complex (MHC) molecules and AFP peptides. This invention relates to T-cell receptors (TCRs) that bind to or recognize such peptide epitopes, including their antigen-binding domains. This application further relates to engineered cells containing such binding molecules, such as TCR bispecific antibodies or TCRs, and their use in cancer immunotherapy.

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