CD3 binding molecules and related methods and uses

Abstract

Provided are binding molecules that bind to CD3, in particular, binding molecules that incorporate human antibodies, including antibody fragments, specific for CD3. In some aspects, the provided binding molecules are bispecific antibodies directed to CD3 and a second antigen, such as a B cell antigen or a tumor antigen. Also provided are polynucleotides that encode the binding molecules, including the antibodies or bispecific antibodies. Also provided are pharmaceutical compositions and methods and uses of such binding molecules for treatment of diseases in which specific targeting, and in some aspects T-cell-mediated killing, of cells that express the second antigen is desired.