Improved DNA constructs for manufacturing messenger RNA by in vitro transcription

TW202641972APending Publication Date: 2026-10-16SANOFI PASTEUR INC
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Patent Information

Application Number
TW114141594
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-10-28
Filing Date
2025-10-28
Publication Date
2026-10-16

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Abstract

The present disclosure provides methods and compositions for improving the in vitro transcription (IVT) of messenger RNA (mRNA) using SP6, T7, or KP34 RNA polymerase. In particular, the present disclosure provides in vitro transcription templates with optimized nucleic acid sequences specific for use with SP6, T7, or KP34 RNA polymerase that improve mRNA transcript yield and / or reduce amounts of dsRNA.
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