AAV particle processing using affinity chromatography with gradient elution

TW202641976APending Publication Date: 2026-10-16F HOFFMANN LA ROCHE & CO AG
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Patent Information

Application Number
TW114150188
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-12-20
Filing Date
2025-12-19
Publication Date
2026-10-16

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Abstract

Herein is reported a method for separating full AAV particles from empty AAV particles, the method comprising the steps of applying a solution comprising full, empty and partially filled AAV particles to an AAV affinity column comprising an AAV affinity material and thereby binding the AAV particles to the AAV affinity material, wherein the solution has a pH in the range of
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