A stabilization system for an agrochemical composition

Abstract

This invention provides a stabilization system for agricultural chemical compositions, the stabilization system comprising at least one stereo-stabilizer and at least one electrostatic stabilizer. This invention further provides an aqueous insecticide composition comprising at least one insecticide and the stabilization system. This invention also discloses a procedure for preparing the aqueous insecticide composition, a method for controlling pests, and the use of the composition as an insecticide.

Description

[Technical Field]

[0001] This invention relates to a stabilization system for agricultural chemical compositions. More specifically, this invention relates to a stabilization system for agricultural chemical compositions containing compounds with poor water solubility. [Previous Technology]

[0002] Compounds with poor water solubility are difficult to develop into pesticide products and face significant challenges in the development of aqueous formulations. A key step in preparing aqueous formulations (such as suspension concentrates of poorly water-soluble compounds) is dispersing the active compound. These active particles should be dispersed so that each submicron or nanoparticle can move independently. Brownian motion prevents these particles from settling once they are separated. Stable suspensions are those in which barriers maintain particle dispersion.

[0003] Agricultural chemicals are preferably formulated as aqueous suspension concentrates because these formulations contain little or no volatile organic compounds. Suspension concentrates (SCs) or aqueous flowable (AFs) are concentrated suspensions of micronized active pesticides in water. These aqueous formulations are typically achieved by suspending the solid active ingredient in an aqueous system containing a suitable surfactant to stabilize the solid particles of the active ingredient, and then pulverizing the active ingredient particles to a desired particle size, typically less than 10 µm. Due to particle growth or agglomeration of the active compound particles, suspension concentrate formulations of solid organic active ingredients tend to be unstable in terms of active ingredient sedimentation. This becomes even more difficult when the active compound is insoluble in water or has poor solubility in water.

[0004] Before spraying onto the target area, dilute the SC with water in the spray tank to achieve the minimum effective pesticide concentration. The SC must be formulated to have low viscosity and good flowability, making it easy and complete to transfer to the spray tank. Good suspension stability is necessary when the active ingredient in the SC is insoluble. If the suspension settles and leaves sediment at the bottom of the container, the pesticide application may be too weak to be effective. Furthermore, the disposal of residues in the container becomes a problem. This requires an efficient dispersant to ensure proper dispersion of the pesticide in water, especially for pesticides with poor water solubility.

[0005] Various water-insoluble active ingredients are used in agricultural applications, including insecticides, herbicides, fungicides, biocides, molluscicides, algaecides, plant growth regulators, insect repellents, rodenticides, nematicides, acaricides, amoebics, protozoacids, crop safety agents, and adjuvants.

[0006] In order to formulate these different groups of active ingredients into suitable formulations, an effective system consisting of suitable surfactants and dispersants is required; and the quantities are balanced. Commonly, known surfactant materials are well known in the art and can be nonionic, amphoteric, cationic, or anionic, or combinations of such surfactants.

[0007] In most cases, anionic surfactants consist of sulfonates, sulfates, or carboxylates with sodium or calcium as relative ions. Nonionic surfactants consist of polymerized glycol ethers or glucose units. They are almost entirely synthesized by the addition of ethylene oxide or propylene oxide to alkylphenols, fatty alcohols, fatty acids, fatty amines, or fatty acid amides. Cationic surfactants contain quaternary ammonium ions as their hydrophilic portion. These surfactants are important due to their antibacterial properties. Amphoteric surfactants containing both cationic and anionic groups in their structure are sometimes called zwitterionic molecules. The properties of zwitterionic surfactants are very similar to those of nonionic surfactants.

[0008] Surfactants and dispersants help to formulate active ingredients in various ways by assisting in the handling, stability, usability, and effectiveness of the formulation. Surfactants also promote the dispersion of poorly water-soluble pesticide particles in aqueous media and prevent the particles themselves from agglomerating. Without suitable surfactants, it becomes difficult or almost impossible to achieve stable formulations in the desired form. Therefore, it is highly desirable to design suitable systems that facilitate the formulation of poorly water-soluble active ingredients into suitable forms. Objective

[0009] The purpose of this invention is to provide a stabilization system for agricultural chemical compositions.

[0010] Another object of the present invention is to provide a stabilization system for agricultural chemical compositions of active ingredients with poor water solubility.

[0011] Another object of the present invention is to provide a stabilization system for aqueous insecticide compositions of active ingredients with poor water solubility.

[0012] Another object of the present invention is to provide a procedure for preparing a stabilization system for agricultural chemical compositions.

[0013] A further object of the present invention is to provide a procedure for preparing an aqueous insecticide composition using a stabilization system. [Summary of the Invention]

[0014] In accordance with the above objectives, the present invention provides a stabilization system for agricultural chemical compositions, the stabilization system comprising: 1) at least one stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and 2) at least one electrostatic stabilizer; wherein the ratio of the stereo stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0015] In accordance with the above objectives, the present invention provides an aqueous insecticide composition comprising: 1) at least one insecticide selected from diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine insecticides; and 2) a stabilization system comprising: a) at least one stereo-stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and b) at least one electrostatic stabilizer; wherein the ratio of the stereo-stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0016] In accordance with the above objectives, the present invention provides an aqueous insecticide composition comprising: 1) at least one insecticide selected from diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine insecticides; 2) at least one stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and 3) at least one electrostatic stabilizer; wherein the ratio of the stereostatic stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0017] In accordance with the above objectives, the present invention provides a procedure for preparing a stabilization system for agricultural chemical compositions, the stabilization system comprising at least one stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereo stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the procedure comprises the following steps: combining the stereo stabilizer and the electrostatic stabilizer together to obtain a mixture; and applying energy of a suitable form to the mixture to obtain the stabilization system.

[0018] To achieve the above objectives, a process for preparing a stabilization system for agricultural chemical compositions includes at least one stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereo stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the process includes the following steps: adding the electrostatic stabilizer to the stereo stabilizer to obtain a mixture; and applying energy of a suitable form to the mixture to obtain the stabilization system.

[0019] In accordance with the above objectives, the present invention provides a procedure for preparing an aqueous insecticide composition comprising: at least one insecticide selected from diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine; at least one stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereostatic stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the procedure comprises the following steps: mixing the insecticide with a stabilization system to obtain a mixture; milling the obtained mixture to obtain a uniform dispersion; and gelling the uniform dispersion to obtain a suspension concentrate composition.

[0020] In accordance with the above objectives, the present invention provides a procedure for preparing an aqueous insecticide composition comprising: at least one insecticide selected from diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine; a stabilization system comprising at least one stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereostatic stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the procedure comprises the following steps: mixing the insecticide and the stabilization system to obtain a mixture; milling the obtained mixture to obtain a uniform dispersion; and gelling the uniform dispersion to obtain a suspension concentrate composition.

[0021] In accordance with the above objectives, the present invention provides a method for controlling unwanted pests, the method comprising applying an insecticidally effective amount of an aqueous insecticide composition to the location of the pest or the like, the aqueous insecticide composition comprising: 1) at least one insecticide selected from the group consisting of: diacetamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacetylhydrazine; 2) at least one stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and 3) at least one electrostatic stabilizer; wherein the ratio of the stereostatic stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0022] In accordance with the above objectives, the present invention provides a use of a stabilization system for formulating agricultural chemical compositions according to the present invention.

[0023] For the above purposes, the water-based insecticide composition controls pests and insects.

[0024] In accordance with the above objectives, the present invention provides a kit of aqueous insecticide compositions comprising: 1) at least one insecticide selected from diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine insecticides; and 2) a stabilization system, wherein the stabilization system comprises: a) at least one stereo-stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and b) at least one electrostatic stabilizer; wherein the ratio of the stereo-stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0025] Additional features and advantages of the present invention will become apparent from the following detailed description, which is illustrated by way of example. The best features of the invention should not be construed as limiting the scope of the invention as described herein.

Implementation Method

[0026] For the purposes of the following embodiments, it should be understood that the present invention can present various alternative variations and sequences of steps, except where explicitly stated otherwise. Furthermore, except in any operational instance, or where otherwise indicated, all figures representing material / component amounts, for example, used in this specification, should be understood to be modified in all cases by the term "about".

[0027] Therefore, before describing the invention in detail, it should be understood that the invention is not limited to the specific exemplified components / systems or program parameters, and such variations are naturally possible. It should also be understood that the terminology used herein is for the purpose of describing specific embodiments of the invention only and is not intended to limit the scope of the invention in any way. The use of any instance in this specification (including instances of any terminology discussed herein) is for illustrative purposes only and does not in any way limit the scope or meaning of the invention or any exemplified terminology. Similarly, the invention is not limited to the various embodiments given in this specification. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In case of conflict, the definitions included in this document shall prevail.

[0028] It should be noted that, as used in this specification, the singular forms "a" and "the" include plural references unless otherwise expressly stated in the text. The terms "preferred" and "preferably" refer to embodiments of the invention that may provide certain benefits in certain environments.

[0029] As used herein, the terms “comprising,” “including,” “having,” “containing,” “involving,” and similar terms shall be understood to be open-ended, meaning including but not limited to.

[0030] In any of the forms or embodiments described below, the phrase "comprising" may be replaced by the phrases "consisting of," "consisting essentially of," or "consisting substantially of." In these forms or embodiments, the combination or composition includes or comprises the specific component described herein or is substantially or substantially composed of said specific component, excluding other fungicides or insecticides or plant growth promoters or adjuvants or excipients not specifically described herein.

[0031] Surprisingly, the inventors of the present invention have discovered that when a stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18 and an electrostatic stabilizer are mixed in a weight ratio of stereo stabilizer to electrostatic stabilizer of 5:1 to about 1:5, a stabilization system for agricultural chemical compositions can be obtained.

[0032] The inventors have discovered that such stabilization systems are highly suitable for formulating agrochemical compositions of active ingredients with poor water solubility. The steps of this invention carefully select the types and proportions of stereo-stabilizers and electrostatic stabilizers to make the stabilization system suitable for formulating most water-insoluble active ingredients, water-insoluble and water-soluble combinations, or combinations with another water-insoluble active ingredient.

[0033] It has been found that stereostatic stabilizers within a narrow range of hydrophilic-lipophilic balance values ​​of 10 to 18 are highly effective in dispersing poorly water-soluble active ingredients. These stereostatic stabilizers also provide a degree of wetting, which facilitates the formulation of dispersions. Electrostatic stabilizers have been found to be best suited for resisting interparticle aggregation forces and preventing active ingredient particles from agglomerating in aqueous dispersions. Definition

[0034] In some embodiments, "poorly water soluble" refers to a pesticide having a solubility in deionized water at 20°C of no more than about 100 mg / L. In some embodiments, the solubility of the pesticide in deionized water at 20°C is no more than about 75 mg / L. In some embodiments, the solubility of the pesticide in deionized water at 20°C is no more than about 50 mg / L. In some embodiments, the solubility of the pesticide in deionized water at 20°C is no more than about 25 mg / L.

[0035] In some embodiments, "steric stabilizer" refers to an additive that inhibits suspension aggregation. These additives include certain water-loving polymers and surfactants with water-loving chains, especially nonionic surfactants. It is believed that these additives coat the system with long rings and tails extending into the solution. Even at high salt concentrations or under conditions where the surface zeta potential is reduced to near zero, the steric stabilized system maintains good dispersion.

[0036] In some embodiments, "static stabilizer" refers to an anionic surfactant that generates surface charge and surface potential in an aqueous suspension, preventing aggregation by maintaining good separation between dispersed particles and between the particles and the surface. The main driving force for particle or droplet aggregation is the general van der Waals attraction, which increases sharply at small spacings. To overcome the van der Waals attraction, the static stabilizer generates a repulsive force (energy) between particles, especially at small to medium spacings.

[0037] This type of repulsive energy can be produced by charge separation and the generation of an electrical double layer. The combination of van der Waals attraction and double-layer repulsion produces an energy-distance curve at various separation distances between particles, which provides an energy barrier at moderate separation and thus provides electrostatic stability in suspensions. The electrostatic stabilizer carries an anionic charge density, which is the ratio of the number of negative charges on the monomer units constituting the polymer to the molecular weight of the monomer units, and is expressed as milliequivalents (meq) (meq / g) of anionic groups per gram of polymer.

[0038] In some embodiments, "hydrophilic-lipophilic balance (HLB)" refers to the size and strength of the hydrophilic and lipophilic portions of a surfactant molecule. It is a numerical system used to describe the relationship between the water-soluble and oil-soluble portions of a nonionic surfactant. HLB values ​​range from 1 to 30.

[0039] Therefore, in one embodiment of the present invention, the stabilization system for agricultural chemical composition comprises: 1) at least one stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and 2) at least one electrostatic stabilizer; wherein the ratio of the stereo stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0040] According to one embodiment of the present invention, a stabilization system for agricultural chemical compositions comprises a stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18.

[0041] According to one embodiment of the present invention, the stereostabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18 is selected from one or more of the following: ethoxylated and propoxylated alcohols, methyl ethylene oxide polymers having ethylene oxide, polyoxyethylene alkyl ethers, methyl methacrylate graft copolymers, polyoxyethylene (20) oil ethers, polyoxyethylene (100) stearate ethers, and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol).

[0042] According to a preferred embodiment of the present invention, the stereostabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18 is selected from the group consisting of: ethoxylated and propoxylated alcohols, methyl ethylene oxide polymers having ethylene oxide, polyoxyethylene alkyl ethers, and methyl methacrylate graft copolymers.

[0043] In one embodiment of the present invention, the stabilization system for agricultural chemical composition comprises about 1% to about 70% w / w and more preferably about 5% to about 60% w / w of a stereostatic stabilizer by weight of the total weight of the stabilization system for agricultural chemical composition.

[0044] In one preferred embodiment of the present invention, the stabilization system for agricultural chemical compositions comprises about 10% to about 50% w / w of a stereochemical stabilizer by weight of the total weight of the stabilization system for agricultural chemical compositions.

[0045] According to one embodiment of the present invention, the stabilization system for agricultural chemical compositions includes an electrostatic stabilizer.

[0046] According to one embodiment of the present invention, the electrostatic stabilizer is selected from one or more of the following: alkylnaphthalene sulfonate (ANS) condensate, sodium lignin sulfonate, naphthyl sulfonate, mono- and di-(C1-C16)-alkylnaphthalene sulfonate, such as, for example, dibutylnaphthalene sulfonate; naphthalene sulfonic acid, and (C1-C16)-alkylnaphthalene sulfonic acid, or phenol sulfonic acid condensate with formaldehyde (= (C1-C16)-naphthalene sulfonate / formaldehyde condensate, (C1-C16)-alkylnaphthalene sulfonate / formaldehyde condensate, and phenol sulfonate / formaldehyde condensate).

[0047] According to a preferred embodiment of the present invention, the electrostatic stabilizer is selected from one or more of the following: alkyl naphthalene sulfonate (ANS) condensate, sodium lignin sulfonate, naphthyl sulfonate, mono- and di-(C1-C16)-alkyl naphthyl sulfonate, such as dibutyl naphthyl sulfonate.

[0048] According to one embodiment of the present invention, the stabilization system for agricultural chemical compositions comprises an electrostatic stabilizer having an anionic charge density in the range of 0.1 to 2.5 meq / g.

[0049] According to one embodiment of the present invention, the stabilization system for agricultural chemical compositions comprises an electrostatic stabilizer having an anionic charge density in the range of 0.5 to 2.0 meq / g.

[0050] In one embodiment of the present invention, the stabilization system for agricultural chemical compositions comprises about 0.1% to about 50% w / w and preferably about 0.5% to about 40% w / w of an electrostatic stabilizer by weight of the total weight of the stabilization system for agricultural chemical compositions.

[0051] In one preferred embodiment of the present invention, the stabilization system for agricultural chemical compositions comprises about 1% to about 30% w / w of electrostatic stabilizer by weight of the total weight of the stabilization system for agricultural chemical compositions.

[0052] According to one embodiment of the present invention, the ratio of the stereo stabilizer to the electrostatic stabilizer in the stabilization system for agricultural chemical compositions is about 5:1 to about 1:5 by weight.

[0053] According to one embodiment of the present invention, the ratio of the stereo stabilizer to the electrostatic stabilizer in the stabilization system for agricultural chemical compositions is about 4:1 to about 1:4 by weight.

[0054] According to a preferred embodiment of the present invention, the ratio of the stereo stabilizer to the electrostatic stabilizer in the stabilization system for agricultural chemical compositions is about 3:1 to about 1:3 by weight.

[0055] In accordance with the above objectives, the present invention provides an aqueous insecticide composition comprising: 1) at least one insecticide selected from diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine insecticides; and 2) a stabilization system comprising: a) at least one stereo-stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and b) at least one electrostatic stabilizer; wherein the ratio of the stereo-stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0056] According to one embodiment of the present invention, the aqueous insecticide composition comprises: 1) at least one insecticide selected from diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine insecticides; 2) at least one stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and 3) at least one electrostatic stabilizer; wherein the ratio of the stereostatic stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0057] According to one embodiment of the present invention, the aqueous insecticide composition comprises at least one insecticide selected from diacetamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacetylhydrazine insecticides.

[0058] According to one embodiment of the present invention, the diamide insecticide in the aqueous insecticide composition is selected from afoxolaner, broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide, fluralaner, lotilaner, tetrachlorantraniliprole, and tetraliprole.

[0059] According to a preferred embodiment of the present invention, the diacetamide insecticide in the aqueous insecticide composition is selected from one or more of the following: cypermethrin, cyantraniliprole, cyclobrombutamide, tetrachlorantraniliprole, and tetrapro.

[0060] According to one embodiment of the present invention, the neonicotinoid insecticide in the aqueous insecticide composition is selected from one or more of the following: clothinidin, dinotefuran, imidacloprid, imidaclothiz, thiamethoxam, nitenpyram, nithiazine, acetamiprid, cycloxaprid, and thiacloprid.

[0061] According to a preferred embodiment of the present invention, the neonicotinoid insecticide in the aqueous insecticide composition is selected from one or more of the following: conicidin, imidacloprid, acetamiprid, cyprodinil, and cyprodinil.

[0062] According to one embodiment of the present invention, the pyrrole insecticide in the aqueous insecticide composition is selected from Kvamex and [4-bromo-2-(4-chlorophenyl)-1-(ethoxy-methyl)-5-(trifluoromethyl)pyrrole-3-carboxylonitrile] (AC 303,630).

[0063] According to one embodiment of the present invention, the benzobenzylurea insecticide in the aqueous insecticide composition is selected from bistrifluron, chlorbenzuron, chlorfluazuron, dichlorbenzuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron, and triflumuron.

[0064] According to a preferred embodiment of the present invention, the benzoylphenylurea component of the aqueous insecticide composition is selected from novalong, diflubenzuron, chlorfluazuron, chlorfluazuron, rofenuron, and triflubenzuron.

[0065] According to one embodiment of the present invention, the diacylhydrazine insecticide component of the aqueous insecticide composition is selected from chromafenozide, furan tebufenozide, halofenozide, methoxyfenozide, tebufenozide, and yishijing.

[0066] According to a preferred embodiment of the present invention, the diacetylhydrazine insecticide component of the aqueous insecticide composition is selected from cophenoxim and mefenoxim.

[0067] According to one embodiment of the present invention, the aqueous insecticide composition comprises about 0.1% to about 70% w / w and more preferably about 1% to about 60% w / w of insecticide by weight of the total weight of the aqueous insecticide composition.

[0068] According to one embodiment of the present invention, the aqueous insecticide composition comprises about 10% to about 50% w / w insecticide by weight of the total weight of the aqueous insecticide composition.

[0069] In one embodiment of the present invention, the aqueous insecticide composition may further include one or more anti-freezing agents, wetting agents, fillers, surfactants, anti-caking agents, pH adjusters, preservatives, biocides, antifoaming agents, colorants, and other formulation additives.

[0070] A suitable antifreeze that can be added to the composition of an aqueous insecticide is an aqueous polyol, such as ethylene glycol, propylene glycol, or glycerin.

[0071] A suitable pH adjuster may be citric acid or phosphoric acid or similar.

[0072] Wetting agents that can be added to the aqueous insecticide composition of the present invention include, but are not limited to, polyaryl alkoxylated phosphates and their potassium salts, such as Soprophor® FLK and Stepfac TSP PE-K. Other suitable wetting agents include block copolymers of polyepoxides, sodium dioctyl sulfosuccinate, such as Geropon® SDS and Aerosol® OT, and ethoxylated alcohols, such as Trideth-6, Rhodasurf® BC 610, Tersperse® 4894, poly(oxy-1,2-ethylenedimethyl), and α-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxane]propyl]-ω-hydroxy- (Silwet 408).

[0073] Optionally, about 0.1 wt% to about 5.0 wt% of an antifoaming agent or defoamer is used to stop the generation of any unwanted foam, while simultaneously manufacturing the suspension concentrate composition of this application. Preferred antifoaming agents are selected from polysiloxane compounds, alcohols, glycol ethers, mineral oils, acetylene diol, polysiloxanes, organosiloxanes, siloxane diols, reaction products of silicon dioxide and organosiloxane polymers, and polydimethylsiloxanes or polyalkylene glycols, alone or in combination. Suitable defoamers include AGNIQUE DFM 111S; SAG-10; SAG-1000AP; SAG-1529; SAG-1538; SAG-1571; SAG-1572; SAG-1575; SAG-200 1; SAG-220; SAG-290; SAG-30; SAG-30E; SAG-330; SAG-47; SAG-5440; SAG-7133; and SAG-770.

[0074] Examples of thickeners based on anionic heteropolysaccharides from the Trichoderma group are Rhodopol 23®, Rhodopol G®, Rhodopol 50 MD®, Rhodicare T®, Kelzan®, Kelzan S®, and Satiaxane CX91®.

[0075] Examples of preservatives include benzisothiazolinone (Proxel GXL) or phenol, 2-bromo-2-nitropropane-1,3-diol (Bioban BP 30), 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one (Kathon CG / ICP), glutaraldehyde (Ucarcide 50), chloromethylisothiazolinone (CMIT) / methylisothiazolinone (MIT) (Isocil Ultra 1.5), 2,2-dibromo-3-nitrilopropioamide (Reputain 20), and streptomycin & nisin, Bronopol / CMIT / MIT (Mergal 721K3).

[0076] Suitable colorants (e.g., red, blue, and green) are preferably pigments (which are not very soluble in water) and dyes (which are soluble in water). Examples of inorganic colorants are iron oxide, titanium oxide, and ferric hexacyanate, while organic colorants are alizarin, azo, and phthalocyanine colorants.

[0077] In one embodiment of the present invention, the aqueous insecticide composition comprises about 1% to about 70% w / w diamide or pyrrole or benzoylphenylurea or diamide hydrazine insecticide of the total weight of the aqueous insecticide composition, and about 1% to about 70% stabilization system.

[0078] In one embodiment of the present invention, the aqueous insecticide composition comprises about 0.1% to about 50% w / w diamide insecticide and about 1% to about 50% stabilization system by weight of the total weight of the aqueous insecticide composition.

[0079] In one embodiment of the present invention, the aqueous insecticide composition comprises about 10% to about 50% w / w diacetamide insecticide and about 10% to about 50% stabilization system by weight of the total weight of the aqueous insecticide composition.

[0080] In one embodiment of the present invention, the aqueous insecticide composition comprises about 10% to about 50% w / w diamide insecticide, at least one other insecticide, and about 10% to about 50% stabilization system by weight of the total weight of the aqueous insecticide composition.

[0081] In one embodiment of the present invention, the aqueous insecticide composition comprises about 1% to about 70% w / w diamide insecticide, about 1% to about 70% w / w pyrrole or benzoylphenylurea or diamide hydrazine insecticide, and about 1% to about 70% stabilization system by weight of the total weight of the aqueous insecticide composition.

[0082] In one embodiment of the present invention, the aqueous insecticide composition comprises about 0.1% to about 50% w / w of the total weight of the aqueous insecticide composition, and about 1% to about 50% of the stabilization system.

[0083] In one embodiment of the present invention, the aqueous insecticide composition comprises about 0.1% to about 50% w / w cypermethrin and about 1% to about 50% stabilization system by weight of the total weight of the aqueous insecticide composition.

[0084] In one embodiment of the present invention, the aqueous insecticide composition comprises about 0.1% to about 50% w / w cyproconazole, and one or more other insecticides.

[0085] In one embodiment of the present invention, the aqueous insecticide composition comprises about 2% to about 50% w / w Cyproheptad, about 0.5% to about 50% w / w Kefantine, and about 10% to about 50% stabilization system by weight of the total weight of the aqueous insecticide composition.

[0086] In one embodiment of the present invention, the aqueous insecticide composition comprises about 5% to about 50% w / w cyproconazole, about 0.5% to about 50% w / w novapro, and about 10% to about 50% stabilization system by weight of the total weight of the aqueous insecticide composition.

[0087] In one embodiment of the present invention, the aqueous insecticide composition comprises about 10% to about 50% w / w of cyproconazole, about 10% to about 50% w / w mefenoxam by weight of the total weight of the aqueous insecticide composition, and about 10% to about 50% of the stabilization system.

[0088] In one embodiment of the present invention, the aqueous insecticide composition comprises about 5% to about 60% w / w Cyprodinil, about 10% to about 90% w / w Diflubenzuron, and about 10% to about 50% of the total weight of the aqueous insecticide composition.

[0089] In one embodiment of the present invention, the aqueous insecticide composition comprises about 1% to about 70% w / w diacetamide insecticide, about 1% to about 70% w / w flupyrimin, and about 1% to about 70% stabilization system, comprising the total weight of the aqueous insecticide composition.

[0090] In one embodiment of the present invention, the aqueous insecticide composition system is formulated into a suspension concentrate, a soluble liquid, an emulsion-in-water, or a formulation for seed (FS).

[0091] In a preferred embodiment, the aqueous insecticide composition of the present invention is a suspension concentrate.

[0092] According to one embodiment of the present invention, a procedure is provided for preparing a stabilization system for agricultural chemical compositions, the stabilization system comprising at least one stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereo stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the procedure comprises the following steps: combining the stereo stabilizer and the electrostatic stabilizer together to obtain a mixture; and applying energy of a suitable form to the mixture to obtain the stabilization system.

[0093] According to one embodiment of the present invention, a procedure is provided for preparing a stabilization system for agricultural chemical compositions; the stabilization system comprises at least one stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereo stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the procedure comprises the following steps: combining the stereo stabilizer and the electrostatic stabilizer together to obtain a mixture; optionally adding water to the mixture and applying energy in a suitable form to obtain the stabilization system.

[0094] According to one embodiment of the present invention, a procedure is provided for preparing a stabilization system for agricultural chemical compositions; the stabilization system comprises at least one stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereo stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the procedure comprises the following steps: adding the electrostatic stabilizer to the stereo stabilizer to obtain a mixture; and applying energy of a suitable form to the mixture to obtain the stabilization system.

[0095] According to one embodiment of the present invention, a procedure is provided for preparing a stabilization system for agricultural chemical compositions, the stabilization system comprising at least one stereostabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereostabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the procedure comprises the following steps: combining an ethoxylated and propoxylated alcohol-based stereostabilizer with a sodium salt of a naphthalene sulfonate condensate condensate as an electrostatic stabilizer and water to obtain a mixture; and applying energy of a suitable form to the mixture to obtain the stabilization system.

[0096] According to one embodiment of the present invention, a process for preparing an aqueous insecticide composition is provided, comprising at least one insecticide selected from the group consisting of: diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine; at least one stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and at least one electrostatic stabilizer; wherein the ratio of the stereostatic stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight; and wherein the process comprises the following steps:

[0097] The insecticide is mixed with a stabilization system to obtain a mixture; the mixture is milled to obtain a uniform dispersion; and the uniform dispersion is gelled to obtain a suspension concentrate composition.

[0098] According to one embodiment of the present invention, the procedure for preparing the aqueous insecticide composition includes the following steps: mixing a diacetamide insecticide with a stabilization system to obtain a mixture; milling the obtained mixture to obtain a uniform dispersion; gelling the uniform dispersion to obtain a suspension concentrate, and packaging the obtained aqueous insecticide composition as a suspension concentrate.

[0099] According to one embodiment of the present invention, the procedure for preparing the aqueous insecticide composition includes the following steps: blending a diamine insecticide, another insecticide selected from pyrrole, benzoylphenylurea, and diazonium insecticide, and a stabilization system comprising a sodium salt of an ethoxylated and propoxylated alcohol surfactant and a naphthalene sulfonate condensate to obtain a mixture; milling the obtained mixture to obtain a uniform dispersion; gelling the uniform dispersion to obtain a suspension concentrate, and packaging the obtained aqueous insecticide composition as a suspension concentrate.

[0100] According to another embodiment of the present invention, in the process of preparing an aqueous insecticide composition, the order of mixing the active ingredients, the stabilization system including the stereo-stabilizer and the electrostatic stabilizer, and optionally other ingredients is not fixed and can be changed according to the formulationr's preference.

[0101] In one embodiment, the particle size distribution D10 of the aqueous insecticide composition of the present invention is less than about 10 micrometers.

[0102] In one embodiment, the particle size distribution D10 of the aqueous insecticide composition of the present invention is less than about 5 micrometers.

[0103] In one embodiment, the particle size distribution D50 of the aqueous insecticide composition of the present invention is less than about 10.0 micrometers.

[0104] In one embodiment, the particle size distribution D50 of the aqueous insecticide composition of the present invention is less than about 5 micrometers.

[0105] In one embodiment, the particle size distribution D50 of the aqueous insecticide composition of the present invention is less than about 2 micrometers.

[0106] In one embodiment, the particle size distribution D90 of the aqueous insecticide composition of the present invention is less than or equal to about 20 micrometers.

[0107] In one embodiment, the particle size distribution D90 of the aqueous insecticide composition of the present invention is less than or equal to about 15 micrometers.

[0108] In one embodiment, the particle size distribution D90 of the aqueous insecticide composition of the present invention is less than or equal to about 10 micrometers.

[0109] According to one embodiment of the present invention, by applying shear force to a mixture of active ingredients, stabilization system, and other adjuvants, the aqueous pesticide composition prepared in the above steps is subjected to particle size reduction. Suitable apparatus for this purpose is an apparatus that provides a milling operation, such as a high-shear mixer (e.g., ROS HSM, Ultra-Turrax equipment, and dissolver), a static mixer (e.g., a system having a mixing nozzle, bead mill, vibratory mill, stirred bead mill, colloid mill, cone mill, circulating mill (stirred ball mill with pin grinding system), disc mill, annular chamber mill, double cone mill, sprocket disperser, or homogenizer), and other homogenizers.

[0110] In one embodiment of the present invention, the aqueous insecticide composition comprises about 1% to about 70% w / w diamide or pyrrole or benzoylphenylurea or diamide hydrazine insecticide or mixtures thereof, and about 1% to about 70% stabilization system, wherein the aqueous insecticide composition is formulated as a suspension concentrate.

[0111] In one embodiment, the present invention provides a suspension concentrate comprising about 1% to about 70% w / w of a diamide or pyrrole or benzoylphenylurea or diamide hydrazine insecticide or a mixture thereof, and about 1% to about 70% of a stabilization system.

[0112] In one embodiment of the present invention, the aqueous insecticide composition comprises about 1% to about 70% w / w diacetamide insecticide of the total weight of the aqueous insecticide composition, and about 1% to about 70% stabilization system, wherein the aqueous insecticide composition is formulated as a suspension concentrate.

[0113] In one embodiment of the present invention, the aqueous insecticide composition comprises about 1% to about 70% w / w dimethicone insecticide, about 1% to about 70% stabilization system, about 20% to about 80% water, about 0.1% to about 40% wetting agent, about 0.1% to about 10% antifreeze, about 0.1% to about 5% defoamer, about 0.1% to about 5% biocide, and about 0.1% to about 5% rheology modifier, wherein the aqueous insecticide composition is formulated as a suspension concentrate.

[0114] In one embodiment of the present invention, the aqueous insecticide composition comprises about 10% to about 50% w / w of cyproconazole, about 1% to about 40% of ethoxylated and propoxylated alcohol-based stereostabilizers, about 1% to about 40% of sodium salt of naphthalene sulfonate concentrate as an electrostatic stabilizer, about 10% to about 80% of water, about 0.1% to about 10% of acrylic copolymer solution, about 0.1% to about 5% of polysiloxane defoamer, about 0.1% to about 5% of biocide, and about 0.1% to about 5% of styrax, wherein the aqueous insecticide composition is formulated as a suspension concentrate.

[0115] According to one embodiment of the present invention, the aqueous insecticide composition system is designed to be diluted with water (or an aqueous solution) to form a corresponding end-use agricultural chemical formulation, generally a spray formulation.

[0116] According to one embodiment of the present invention, the pH range of the aqueous insecticide composition is 5 to 9.

[0117] According to one embodiment of the present invention, when the aqueous insecticide composition is stored at 54°C for 24 hours to 28 days, the pH change is no more than 20%.

[0118] According to one embodiment of the present invention, the aqueous insecticide composition allows the active compound to be absorbed by pests and insects.

[0119] According to one embodiment of the present invention, the aqueous insecticide composition is used as a source of active agricultural chemicals and is generally diluted to form an end-use formulation, typically a spray formulation. It can be diluted with water at 1 to 10,000 times, particularly 10 to 1,000 times, the total weight of the aqueous insecticide composition to form a spray formulation. The aqueous insecticide composition can be diluted to a concentration of agricultural chemical activity of about 0.5 wt.% to about 1 wt.%. In the diluted composition, the concentration of agricultural chemical activity at the time of spraying can be in the range of about 0.001 wt.% to about 1 wt.% of the total formulation.

[0120] A spray formulation includes all components intended to be applied to the plant or its environment. Spray formulations can be prepared by: simply diluting an aqueous pesticide composition containing an agrochemically active ingredient, or by mixing individual agrochemically active ingredients, or by combining diluted aqueous pesticide compositions, and further adding individual agrochemically active ingredients or mixtures thereof. Generally, this end-use mixing is carried out in a tank (from which the formulation is sprayed), or alternatively in a storage tank used to fill the spray tank. Such mixing and blending are generally referred to as tank mixing and tank blending.

[0121] In accordance with the above objectives, the present invention provides a method for controlling unwanted pests, the method comprising applying an insecticidally effective amount of an aqueous insecticide composition to the location of the pest or the like, the aqueous insecticide composition comprising: 1) at least one insecticide selected from diacetamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacetylhydrazine; 2) at least one stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and 3) at least one electrostatic stabilizer; wherein the ratio of the stereostatic stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0122] In accordance with the above objectives, the present invention provides a method for controlling unwanted pests, the method comprising applying an insecticidal effective amount of an aqueous insecticide composition to the location of the pest or the like, the aqueous insecticide composition comprising: (1) cyproconazole; (2) polyoxyethylene alkyl ether, which serves as a stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and (3) a sodium salt of naphthalene sulfonate condensate, which serves as an electrostatic stabilizer.

[0123] In accordance with the above objectives, the present invention provides a method for controlling unwanted pests, the method comprising applying an effective amount of an aqueous insecticide composition to the location of the pest or the like, the aqueous insecticide composition comprising: (1) Cyprodinil; (2) Kefnark; (3) an ethoxylated and propoxylated alcohol-based stereostabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and (4) a sodium salt of a naphthalene sulfonate condensate, which serves as an electrostatic stabilizer.

[0124] In accordance with the above objectives, the present invention provides a method for controlling unwanted pests, the method comprising applying an insecticidal effective amount of an aqueous insecticide composition to the location of the pest or the like, the aqueous insecticide composition comprising: (1) cyproconazole; (2) methoxyphen ...

[0125] In accordance with the above objectives, the present invention provides a method for controlling unwanted pests, the method comprising applying an insecticidal effective amount of an aqueous insecticide composition to the location of the pest or the like, the aqueous insecticide composition comprising: (1) cyproconazole; (2) novapro; (3) a methyl ethylene oxide polymer having ethylene oxide as a stereostatic stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and (4) sodium lignosulfonate as an electrostatic stabilizer.

[0126] According to one embodiment of the present invention, the stabilization system is used to formulate agricultural chemical components.

[0127] According to one embodiment of the present invention, the stabilization system is used to formulate water-based insecticide compositions.

[0128] According to one embodiment of the present invention, an aqueous insecticide composition controls pests and insects.

[0129] In one embodiment of the present invention, the aqueous insecticide composition controls the following pests and insects: insects from the order Lepidoptera, such as small cutworm (Agrotis ypsilon), sugarcane two-spotted moth (Chilo infuscatellus), corn borer (Chilo partellus), rice stem borer (Chilo suppressalis), leafminer (Cnaphalocerus medinalis), codling moth (Cydia pomonella), green-striped diamondback moth (Earias vitella), Egyptian diamondback moth (Earias insulana), cotton lacewing (Helicoverpa armigera), yellow-spotted leafminer (Leucinodes orbonalis), bean pod borer (Maruca testulalis), armyworm (Mythimna separata), cotton bollworm (Pectinophora gossypiella), and citrus leafminer (Phyllocnisitis). The species include: citrella, diamondback moth (Pieris bras-sicae), diamondback moth (Plutella xylostella), rice stem borer (Scirpophaga incertulas), rice stem borer (Sesamia inferens), fall armyworm (Spodoptera frugiperda), African cotton leaf roller (Spodoptera littoralis), beet armyworm (Spodoptera litura), rice stem borer (Tryporyza novella), tomato cutworm (Tuta absoluta), and spruce leafroller (Zeiraphera canadensis). Beetles (Coleoptera), such as the long-horned leaf beetle (Diabrotica longicornis), cucumber semi-punctata, cucumber leaf beetle (Diabrotica punctata), South American leaf beetle (Diabrotica speciosa), corn root beetle (Diabrotica virgifera), rice iron beetle (Dicladispa armigera), Mexican bean beetle (Epilachna varivestis), bicolor beetle (Holotrichia bicolor), red-breasted beetle (Holotrichia consanguinea), and Colorado leaf beetle (Leptinotarsa ​​decemlineata).Flies (Dipteran), such as *Atherigona orientalis*, *Dacus cucurbitae*, *Liriomyza trifolii*, and *Melanagromyza obtuse*; thrips (Thysanoptera), such as *Frankliniella occidentalis*, *Frankliniella tritici*, *Scirtothrips citri*, *Scirtothrips dorsalis*, *Thrips oryzae*, *Thrips palmi*, and *Thrips tabaci*; Termites (Isoptera), such as *Calotermes flavicollis*, *Coptotermes formosanus*, and *Heterotermes*. *Aureus*, *Leucotermes flavipes*, *Microtermes obesi*, *Odontotermes obesus*, *Reticulitermes flavipes*, *Termes natalensis*, and bugs (Hemiptera), for example,Two-spotted green leafhopper (Amrasca biguttula biguttula), small leafhopper (Amrasca devastans), lemon long-tipped leafhopper (Amritodus atkinsoni), cotton aphid (Aphis gossypii), bean aphid (Aphis crassivora), silver leaffly (Bemisia argentifolii), tobacco whitefly (Bemisia tabaci), red-spotted stink bug (Dysdercus cingulatus), broad bean green leafhopper (Empoasca fabae), leafhopper (Idioscopus spp.), peach aphid (Myzus persicae), brown planthopper (Nilaparvata lugens), two-spotted black-tailed leafhopper (Nephotettix virescens), false black-tailed leafhopper (Nephotettix nigropictus), mealybug (Planococcus spp.), mealybug (Pseudococcus spp.), duckweed lanternfly (Pyrilla) The genera *Psylla* (perpusilla), *Sogatella furcifera* (whitefly), *Trialeurodes vaporariorum* (greenhouse whitefly), *Toxoptera aurantiia* (small orange aphid), *Psylla* (psylla spp.), *Rhopalosiphum* (rhopalosiphum spp.), and *Sitobion* (sitobion spp.) are mentioned.

[0130] According to one embodiment of the present invention, the aqueous insecticide composition can be applied to any and all developmental stages of pests, such as eggs, larvae, pupae, and adults. Pests can be controlled by bringing an effective amount of the composition of the present invention into contact with the target pest, its food supply, habitat, breeding ground, or its location.

[0131] According to one embodiment of the present invention, an aqueous insecticide composition comprising various mixtures is highly effective in controlling insect pests in GMO (Genetically Modified Organism) and non-GMO varieties of the following: cotton (Gossyspium spp.), rice (Oryza sativa), wheat (Triticum clustavum), corn (Zea mays), sugarcane (Saccharum officinarum), sugar beet (Beta vulgaris), soybean (Glycin max), peanut (Arachis hypogaea), mung bean (Vigna radiata), black bean (Vigna mungo), chickpea (Cicer arietinum), tree bean (Cajanus cajan), eggplant (Solanum melongena), cabbage (Brassica oleracea var. capitata), cauliflower (Brassica oleracea var. botrytis), okra (Abelmoschus esculentus), and onion (Allium cepa). L.), Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Chili (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Melon (Cucumis melo), Watermelon (Citrullus lanatus), Gourd (Lagenaria siceraria), Apple (Melus domestica), Banana (Musa spp.), Citrus (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Lychee (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum), Tea Tree (Camellia sinensis), Coffee (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Fennel (Cuminum) cyminum).

[0132] In accordance with the above objectives, the present invention provides a kit of aqueous insecticide compositions comprising: 1) at least one insecticide selected from diamide, neonicotinoid, pyrrole, benzoylphenylurea, and diacylhydrazine insecticides; and 2) a stabilization system comprising: a) at least one stereo-stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18; and b) at least one electrostatic stabilizer; wherein the ratio of the stereo-stabilizer to the electrostatic stabilizer is about 5:1 to about 1:5 by weight.

[0133] According to one embodiment of the present invention, the various components of an aqueous insecticide composition may be used individually or partially or completely mixed with each other to prepare the composition according to the present invention. They may also be packaged and further used as combined compositions, such as sets of components.

[0134] In one embodiment of the invention, the kit may include one or more (including all) components that can be used to prepare an aqueous insecticide composition. For example, the kit may include an active ingredient and / or a stabilization system. One or more components may have been combined together or pre-formulated. In those embodiments where the kit provides more than two components, these components may have been combined together and packaged in a single container, such as a vial, bottle, jar, pouch, bag, or can.

[0135] In other embodiments, two or more components of the kit may be packaged separately, i.e., without pre-mixing. Thus, the kit may include one or more separate containers, such as vials, jars, bottles, pouches, bags, or cans, each containing separate components for the aqueous insecticide composition.

[0136] In both forms, the components of the kit may be applied separately from or together with further components, or may be used as components of the combined composition according to the invention for preparing the aqueous insecticide composition according to the invention.

[0137] In one preferred embodiment of the present invention, the aqueous insecticide composition comprises (a) diacetamide or neonicotinoid or pyrrole or benzoylphenylurea or diacetylhydrazine insecticide or mixtures thereof; and (b) the stabilization system is in the form of a single package or a multi-package kit.

[0138] All features described herein can be combined with any of the above-mentioned states in any combination.

[0139] To make the present invention more readily understood, reference will now be made to the following description by way of example. It will be understood that, unless otherwise stated herein, or unless otherwise stated in the referenced test methods and procedures, all listed tests and physical properties have been determined at atmospheric pressure and room temperature (i.e., 25°C). Examples

[0140] Example 1: 5:1% Stabilization System Element Amount(%w / w) Block copolymers of polyepoxides 50 Sodium salts of sulfonated aromatic polymers 10 water qs

[0141] 50g of a block copolymer of polyepoxide and 10g of sodium salt of sulfonated aromatic polymer were mixed together, and water was added under continuous stirring to obtain a stabilized system.

[0142] Example 2: 3:1% Stabilization System Element Amount(%w / w) Nonionic polyalkylene glycol ethers without NPE 45 acrylic copolymer solution 15 water qs

[0143] 45g of NPE-free nonionic polyalkylene glycol ether (Atlas G-5000®), 15g of acrylic copolymer solution, and water were added under continuous stirring to obtain a stabilized system.

[0144] Example 3: 5:1% Stabilization System Element Amount(%w / w) Nonionic polyalkylene glycol ethers without NPE 2.5 Sodium salts of sulfonated aromatic polymers 0.5 water qs

[0145] 2.5 g of NPE-free nonionic polyalkylene glycol ether, 0.5 g of sodium salt of sulfonated aromatic polymer, and water were added under continuous stirring to obtain a stabilized system.

[0146] Example 4: 18.5% Cyprohepta SC Element quantity(%) Cyssoambo 19.5 Propylene glycol 5.0 Stabilization system 3.0 Polysiloxane defoamer 0.2 biological agents 0.2 Sanxianjiao 0.25 water QS total 100.00

[0147] 71.85 g of water was added to a slurry preparation container. 5 g of propylene glycol, 3 g of stabilization system, 0.2 g of polyoxyethylene defoamer, 0.2 g of biodegradant, and 0.25 g of styrax were added to the slurry preparation container under continuous stirring to obtain a slurry. The slurry was then fed into a bead mill to achieve the desired particle size. After the slurry reached the desired particle size, it was transferred to a gelation container. 0.25 g of styrax, 0.2 g of biodegradant, and 71.85 g of water were mixed together under stirring to obtain a gel. A pre-weighed amount of gel was added to the gelation container and stirred continuously. The mixture was homogenized for at least 1 hour. The homogenized mixture was then set to uniformly gelled to obtain the final suspension concentrate composition. The stabilization system was obtained using 2.5 g of polyoxyethylene alkyl ether (NPE-free) and 0.5 g of sodium salt of naphthalene sulfonate condensate (NSC).

[0148] Example 5: 18.5% Cyprohepta SC Element quantity(%) Cyssoambo 19.50 Propylene glycol 5.00 Stabilization system 2.8 Antifoaming agent 0.2 biological agents 0.2 Sanxianjiao 0.25 water QS total 100.00

[0149] 19.5g of Cyproconazole, 5.0g of propylene glycol, 2.8g of stabilization system, 0.2g of antifoaming agent, 0.2g of biodegrading agent, 0.25g of trisaccharide gum, and 72.35g of water were mixed in the above amounts and processed according to the procedure given in Example 4 to obtain a suspension concentrate composition. The stabilization system was obtained by mixing 2.5g of polyoxyethylene alkyl ether (NPE-free) and 0.3g of sodium salt of naphthalene sulfonate condensate (NSC).

[0150] Example 6: 24 g / L Cyproheptad + 490 g / L Kvanpai SC Element quantity(%) Cyssoambo 2.4 Kvanist 49 Stabilization system 6.7 Propylene glycol 5.0 Polysiloxane antifoaming agent 0.7 biological agents 0.2 Sanxianjiao 0.18 water QS total 100.00

[0151] 2.4g of Cyproconazole, 49g of Kefantine, 6.7g of stabilization system, 5.0g of propylene glycol, 0.7g of polysiloxane antifoaming agent, 0.2g of biodegrading agent, 0.18g of styrax, and the amount of water required to make up the volume were mixed in the above amounts and processed according to the procedure given in Example 4 to obtain the suspension concentrate composition. The stabilization system was obtained by mixing 3.5g of a polyepoxide block copolymer, 1.7g of a polymer surfactant, and 1.5g of a sodium salt of a sulfonated aromatic polymer.

[0152] Example 7: 105 g / L Cyproheptadine + 420 g / L Mefenoxate SC Element quantity(%) Cyssoambo 10.5 Eliminate Fenox 42 Stabilization system 7.2 Propylene glycol 5.0 Polysiloxane antifoaming agent 0.7 biological agents 0.2 Sanxianjiao 0.18 water QS total 100.00

[0153] 9.41g of Cyproheptadine, 37.63g of Mefenoxam, 7.2g of stabilization system, 5.0g of propylene glycol, 0.7g of polysiloxane antifoaming agent, 0.2g of biodegrading agent, 0.18g of styrax, and the amount of water required to make up the volume were mixed in the above amounts and processed according to the procedure given in Example 4 to obtain the suspension concentrate composition. The stabilization system was obtained by mixing 3.5g of a polyepoxide block copolymer, 1.7g of a polymer surfactant, and 2g of a sodium salt of a sulfonated aromatic polymer.

[0154] Example 8: 92 g / L Norvatron + 56 g / L Cyproheptadine SC Element quantity(%) Cyssoambo 5.73 Novalon 9.18 Stabilization system 2.5 Polysiloxane antifoaming agent 0.20 Propylene glycol 7.00 Sanxianjiao 10.00 clay 0.90 biological agents 0.10 water QS total 100.00

[0155] 5.73g of Cyproconazole, 9.18g of Norvallon, 3.5g of stabilization system, 0.2g of polysiloxane antifoaming agent, 7.0g of propylene glycol, 10.0g of styrax, 0.9g of clay, 0.1g of biodegradant, and 62.88g of water were mixed in the above amounts and processed according to the procedure given in Example 4 to obtain a suspension concentrate composition. The stabilization system was obtained by mixing 1g of sodium lignosulfonate and 1.5g of block copolymer solution.

[0156] Example 9: Cyprocon 50 + Diflubenzuron 400 g / L SC Element Amount(%w / w) Cyssoambo 5 Erfulong 40 Propylene glycol 5.00 Stabilization system 5.00 Antifoaming agent 0.50 biological agents 0.15 Sanxianjiao 0.20 water QS total 100.00

[0157] Cyprodinil, diflubenzuron, propylene glycol, antifoaming agent, biodegradant, trisaccharin, and water were mixed in the amounts described above and processed according to the procedure given in Example 4 to obtain a suspension concentrate composition. The stabilization system consisted of 3 g Atlox 4894, 1.5 g acrylic copolymer solution, and 0.5 g sodium alkylnaphthalene sulfonate formaldehyde polymer.

[0158] Example 10: Cyproheptad (CTPR) 400 g / L SC Element Quantity (%w / w) Cyssoambo 36.31 Propylene glycol 5.00 Stabilization system 6.00 Antifoaming agent 0.50 biological agents 0.20 Sanxianjiao 0.20 water QS total 100.00

[0159] Cyproconazole, propylene glycol, stabilization system, antifoaming agent, biodegrading agent, trimethylolpropane, and water were mixed in the amounts described above and processed according to the procedure given in Example 4 to obtain a suspension concentrate composition. The stabilization system consisted of 3 g Atlox 4894, 2.5 g Atlox 4913, and 0.5 g sodium alkylnaphthalene sulfonate formaldehyde polymer.

[0160] Example 11: Composition of Cyprom + Formavirin SC Element Quantity (%w / w) Cyssoambo 5.6 Fulabilimin 18.5 Propylene glycol 5.0 acrylic polymer 1.0 acrylic copolymer solution 2.50 lignin sulfonates 0.50 Polysiloxane antifoaming agent 0.50 Sanxianjiao 0.20 water QS total 100.00

[0161] Pour the required amount of water into a slurry preparation container. Add all remaining RM components of approved quality: acrylic polymer (Envipol 871), acrylic copolymer solution (Atlox 4913), and lignin sulfonate (Polyphon H). While stirring, add the industrial grade (technical) to the solution to form a slurry. Mill and transfer the slurry to a gelation container. Add the required amount of styrax and preservative to water while stirring to obtain a gel. Transfer the material from the gelation container to an FG storage tank and achieve the desired structural level.

[0162] Example 12: Stability data of the composition of the present invention parameter Example 4 Example 5 environment 14-day AHS environment 14-day AHS Appearance A grayish-white suspended concentrate containing no foreign substances. No top separation or settling. A grayish-white suspended concentrate containing no foreign substances. No top separation or settling. Grayish-white suspended concentrate without foreign substances A grayish-white suspended concentrate containing no foreign substances. No top separation or settling. Cyprom's active content 18.60 18.58 19.05 19.04 pH (1.0% aqueous suspension) 6.44 6.50 5.8 6.5 Passed the wet sieve test at 45 µm (minimum % w / w). 100 100 100 100 Suspensionability as a Foundation of AI (%w / w) 96.2 95.6 96.31 96.19 The spontaneous nature of the dispersion under gravity (%w / w) 104 102 108 107.7 Foaming that persists after 1 minute, in ml. (in standard hard water D) Nil Nil Nil Nil Density (g / ml) at 20°C 1.088 NA 1.084 NA Viscosity (in cP) (62 spools, 60 RPM) 275 266 258 257 Particle size distribution D10 D50 D90 0.90 1.97 6.43 0.59 1.41 5.43 0.70 1.98 6.52 0.70 1.86 5.63 parameter Example 6 Example 7 environment 14-day AHS environment 14-day AHS Appearance A grayish-white suspended concentrate containing no foreign substances. A grayish-white suspended concentrate containing no foreign substances. A grayish-white suspended concentrate containing no foreign substances. A grayish-white suspended concentrate containing no foreign substances. Active ingredients - - - - Eliminate Fenox - - 432.15 423.54 Cyssoambo 24.46 24.22 104.29 100.71 Kvanist 487.39 485.8 pH (as such) 6.62 6.51 6.58 6.56 pH (1% aqueous solution) NA NA NA NA Suspensibility (activity) - - - - Eliminate Fenox - - 96.9 95.8 Cyssoambo 96.6 95.6 97.2 97 Kvanist 90.3 83 Wet sieve test (material passing through a 200 BSS sieve) 100 100 100 100 The foaming continued after 5 minutes (in 20 PPM water). 0 0 0 0 density 1.22 NA 1.119 NA Viscosity 62, spool 5 RPM 1872 1650 3120 2748 Particle size D 10 0.93 1.61 0.78 0.89 D 50 3.04 4.43 2.36 2.76 D 90 8.34 11.3 7.12 8.03 Example 8 parameter environment 14-day AHS Appearance A grayish-white suspended concentrate containing no foreign substances. A grayish-white suspended concentrate containing no foreign substances. Norvallon degradation % w / w 9.05 9.06 Conidine degradation % w / w Cypro degradation % w / w 5.46 5.45 Norvallon suspension %w / w 95.6 93.9 Cyclone Ampere Floatability %w / w 97.5 96.8 1% pH aqueous solution 7.51 7.36 Continuous foam, measured in ml 50 52 Wet sieve retention on a 75-micron test sieve Nil Nil Viscosity at 20°C, expressed in cp 386 403 Particle size D-10 0.697 0.761 D-50 2.23 2.65 D-90 6.98 7.94 D-95 9.31 10.4 D-average 3.34 3.76 parameter Example 9 Example 10 environment 14-day AHS environment 14-day AHS Appearance A grayish-white suspended concentrate containing no foreign substances. A grayish-white suspended concentrate containing no foreign substances. A grayish-white suspended concentrate containing no foreign substances. A grayish-white suspended concentrate containing no foreign substances. Active ingredients Erfulong 400.5 400.6 Cyssoambo 50.5 50.1 410 409.4 pH (as such) NA NA NA NA pH (1% aqueous solution) 6.07 5.95 6.60 6.32 Suspensibility (activity) Erfulong 99.2 99.0 Cyssoambo 95.5 94.5 95.4 92.30 Wet sieve test (material passing through a 200 BSS sieve) 100 100 100 100 The foaming continued after 5 minutes (in 20 PPM water). 0 0 0 0 density 1.170 NA 1.176 NA Viscosity 62, spool 60 RPM 304 297 348 326 Particle size D 10 0.91 1.07 0.67 0.72 D 50 2.96 3.38 1.82 1.90 D 90 8.80 10.0 6.82 7.0 in conclusion:

[0163] The stabilization system developed according to the present invention has been successfully used to formulate aqueous pesticide compositions containing various active ingredients. Stabilization systems containing stereostabilizers within a narrow range of hydrophilic-lipophilic balance values ​​of 10 to 18 have been found to be highly effective in dispersing poorly water-soluble active ingredients. These stereostabilizers also provide a degree of wetting, which facilitates the formulation of dispersions. Selected electrostatic stabilizers have been found to be most suitable for resisting interparticle aggregation forces and preventing active ingredient particles from agglomerating in aqueous dispersions. Careful selection of the ratio of stereostabilizers to electrostatic stabilizers during formulation of the stabilization system, and its use in formulating aqueous pesticide compositions, achieves superior stability. The aqueous pesticide compositions of the present invention provide excellent stability over time and at various temperatures. Furthermore, the aqueous pesticide compositions obtained through this process exhibit excellent suspendability, good dispersibility, very low or no sedimentation, and minimal particle degradation.

Claims

1. A water-based insecticide composition, comprising: (a) 0.1 to 70% w / w of an insecticide of the total weight of the aqueous insecticide composition, the insecticide being selected from the group comprising: chlorantraniliprole, or chlorantraniliprole and chlorfenapyr, or chlorantraniliprole and methoxyfenozide, or chlorantraniliprole and novaluron, or chlorantraniliprole and diflubenzuron, or chlorantraniliprole and flupyrimin, or chlorantraniliprole and clothianidin; and (b) a stabilization system comprising: i) A stereo stabilizer having a hydrophilic-lipophilic balance value in the range of 10 to 18, the stereo stabilizer being selected from ethoxylated and propoxylated alcohols, methyl ethylene oxide polymers having ethylene oxide, polyoxyethylene alkyl ethers, methyl methacrylate graft copolymers, polyoxyethylene (20) oil ethers, and polyoxyethylene (100) stearate ethers, (ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), and block copolymers of polyoxyethylene; and ii) an electrostatic stabilizer being selected from alkyl naphthalene sulfonate (ANS) condensates, sodium lignin sulfonate, naphthyl sulfonate, mono- and di-(C1-C16)-alkyl naphthyl sulfonate, condensates of naphthalene sulfonic acid, (C1-C16)-naphthalene sulfonate / formaldehyde condensates, (C1-C16)-alkyl naphthalene sulfonate / formaldehyde condensates, phenol sulfonate / formaldehyde condensates, and sodium salts of sulfonated aromatic polymers; The ratio of the stereo stabilizer to the static stabilizer by weight is 5:1 to 1:

5.

2. The aqueous insecticide composition as claimed in claim 1, wherein the composition comprises 0.1% w / w to 50% by weight of Cyproheptad and 1% w / w to 50% w / w of a stabilizing system.

3. The aqueous insecticide composition as claimed in claim 1, wherein the composition includes Cyprodinil and the stabilization system comprising the stereo stabilizer and the static stabilizer in a weight ratio of 5:1 to 1:

5.

4. The aqueous insecticide composition as claimed in claim 1, wherein the composition comprises cyproconazole, novapro, and the stabilization system comprising the stereo stabilizer and the static stabilizer in a weight ratio of 5:1 to 1:

5.

5. The aqueous insecticide composition as claimed in claim 1, wherein the composition comprises Cyprodin, Kefantine, and the stabilization system comprising the stereo stabilizer and the static stabilizer in a weight ratio of 5:1 to 1:

5.

6. The aqueous insecticide composition as claimed in claim 1, wherein the composition comprises cyproconazole, mefenoxam, and the stabilization system comprising the stereo stabilizer and the static stabilizer in a weight ratio of 5:1 to 1:

5.

7. The aqueous insecticide composition as claimed in claim 1, wherein the composition comprises cyprodinil, cinetin, and the stabilization system comprising the stereo stabilizer and the static stabilizer in a weight ratio of 5:1 to 1:

5.

8. The aqueous insecticide composition as claimed in claim 1, wherein the composition comprises Cyprodin, Diflubenzuron, and the stabilization system comprising the stereo stabilizer and the static stabilizer in a weight ratio of 5:1 to 1:

5.

9. The aqueous insecticide composition as claimed in claim 1, wherein the composition comprises Cyprodin, Formapirin, and the stabilization system wherein the ratio of the stereo stabilizer to the static stabilizer is 5:1 to 1:5 by weight.

10. The aqueous insecticide composition as claimed in claim 1, wherein the particle size distribution D50 is in the range of 2 micrometers to 10 micrometers.

11. The aqueous insecticide composition as claimed in claim 1, wherein the particle size distribution D90 is in the range of 10 micrometers to 20 micrometers.