Cosmetic composition and use thereof

Abstract

This invention relates to cosmetic compositions for topical application to the skin to control seborrhea, comprising at least one kelp extract and at least one hydrolyzed hyaluronic acid salt.

Description

[Technical Field]

[0001] This invention relates to the field of cosmetic compositions and / or dermatological compositions. Specifically, this invention relates to cosmetic compositions and / or dermatological compositions for topical application. [Previous Technology]

[0002] Seborrhea or oily skin is a common cosmetic or dermatological problem. When oversized sebaceous glands produce excessive sebum, seborrhea occurs, resulting in oily and shiny skin with visible pores and acne.

[0003] Inhibiting lipid production is one of the main ways to effectively control seborrheic dermatitis. In in vitro studies, Oil Red or Nile Red staining is a common method for assessing the effect of active ingredients on lipid production. For example, isotretinoin is one of the well-known compounds used to control seborrheic dermatitis, and it has been reported to reduce lipid production in sebaceous gland cells (Cemil, BC, et al., 2016).

[0004] Pharmacological downregulation of IGF-I is another promising strategy for treating acne vulgaris. Epigallocatechin-3-gallate (EGCG), a major polyphenol fraction of green tea, has been found to have clinical efficacy as an acne treatment agent through its anti-IGF-I action. It can inhibit IGF-1-induced lipid production and cell proliferation (Im, M., et al., 2012).

[0005] Therefore, excessive oil is undesirable in cosmetic and dermatological terms, and controlling sebum production is the most challenging yet effective way to improve oily skin conditions. Skin problems such as acne, sebum production, and enlarged pores can be addressed by restoring the skin's physiological balance through inhibiting excessive sebum production.

[0006] EP3334403A1 discloses a topical composition comprising plum leaf extract, encapsulated resveratrol, oligopeptide-1 and nicotinamide, and optionally one or more of cactus fruit extract, malachite extract and / or adenosine, wherein the topical composition can reduce sebum secretion in the skin.

[0007] CN105193659A discloses an oil-controlling and acne-removing composition containing aloe vera, which includes aloe vera extract, kelp extract, etc. The composition utilizes natural plant extracts to achieve oil control, greatly reducing the amount of sebum secreted, and is continuously effective.

[0008] Existing seborrhea control technologies typically utilize chemical substances or natural extracts to reduce sebum secretion. More effective technologies for seborrhea control are still needed.

[0009] References: Cemil BC, et al. Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients. Postepy Dermatol Alergol. 2016; 33(4): 294-299; Im, M., et al. Epigallocatechin-3-gallate suppresses IGF-I-induced lipogenesis and Cytokin expression in SZ95 sebocytes. J Invest Dermatol. 2012; 132(12): 2700-2708; Alestas, T., et al. Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands. Journal of Molecular Medicine. 2005; 84(1): 75-87 Pezzani R, et al. Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective, Medicina (Kaunas). 2019; 55(4):110. [Summary of the Invention]

[0010] This invention is based on the discovery that a combination of at least one kelp extract and at least one hydrolyzed hyaluronic acid salt unexpectedly exhibits a synergistic inhibitory effect on lipid production in sebaceous gland cells. Compared to the sebum-suppressing effect achieved by using either active ingredient alone, this combination further inhibits the lipid production process. This enables an excellent solution for controlling seborrhea and preventing acne, particularly in cosmetic or dermatological applications.

[0011] Therefore, the object of the present invention is to provide a seborrhea control technology that can inhibit lipid production in a more effective manner.

[0012] The inventors have now discovered that the object of the present invention can be achieved through the following aspects.

[0013] In one aspect, the present invention provides a cosmetic composition comprising at least one kelp extract and at least one hydrolyzed hyaluronic acid salt.

[0014] According to one embodiment, the kelp extract is selected from Laminaria Saccharina extract (LS extract), Laminaria Digitata extract (LD extract), Laminaria Ochroleuca extract (LO extract), Laminaria Algae extract (LA extract), and mixtures thereof. According to a preferred embodiment, the kelp extract is Laminaria Saccharina extract.

[0015] According to one embodiment, the hydrolyzed hyaluronic acid salt is selected from hydrolyzed zinc hyaluronic acid (miniHA-Zn), hydrolyzed potassium hyaluronic acid (miniHA-K), hydrolyzed calcium hyaluronic acid (miniHA-Ca), and mixtures thereof. According to a preferred embodiment, the hydrolyzed hyaluronic acid salt is hydrolyzed zinc hyaluronic acid.

[0016] According to one embodiment, the weight ratio of kelp extract to hydrolyzed hyaluronic acid salt in the cosmetic composition is equal to or greater than 1:100. According to a preferred embodiment, the weight ratio of kelp extract to hydrolyzed hyaluronic acid salt in the cosmetic composition is from about 1:10 to about 500:1. According to a more preferred embodiment, the weight ratio of kelp extract to hydrolyzed hyaluronic acid salt in the cosmetic composition is from about 1:2 to about 100:1. According to a particularly preferred embodiment, the weight ratio of kelp extract to hydrolyzed hyaluronic acid salt in the cosmetic composition is from about 1:1 to about 40:1.

[0017] According to one embodiment, the kelp extract is present in the cosmetic composition in an amount of about 0.0005% by weight to about 5% by weight based on the total weight of the cosmetic composition. According to a preferred embodiment, the kelp extract is present in the cosmetic composition in an amount of about 0.0008% by weight to about 1% by weight based on the total weight of the cosmetic composition. According to a more preferred embodiment, the kelp extract is present in the cosmetic composition in an amount of about 0.001% by weight to about 0.1% by weight based on the total weight of the cosmetic composition.

[0018] According to one embodiment, hydrolyzed hyaluronic acid salt is present in the cosmetic composition in an amount of about 0.0001% by weight to about 5% by weight, based on the total weight of the cosmetic composition. According to a preferred embodiment, hydrolyzed hyaluronic acid salt is present in the cosmetic composition in an amount of about 0.0002% by weight to about 1% by weight, based on the total weight of the cosmetic composition. According to a more preferred embodiment, hydrolyzed hyaluronic acid salt is present in the cosmetic composition in an amount of about 0.001% by weight to about 0.05% by weight, based on the total weight of the cosmetic composition.

[0019] According to one embodiment, the cosmetic composition comprises about 0.001% to about 0.1% by weight of kelp extract and about 0.001% to about 0.05% by weight of hydrolyzed zinc hyaluronic acid based on dry weight, and wherein the weight ratio of kelp extract to hydrolyzed zinc hyaluronic acid is in the range of about 1:1 to about 40:1.

[0020] According to one embodiment, the cosmetic composition further comprises at least one active ingredient selected from the following: sugar derivatives, natural extracts, ferments, vitamins, urea, caffeine, salicylic acid and its derivatives, α-hydroxy acids and their derivatives, retinoids, nicotinamide, humectants, sunscreens, peppermint oil, aloe vera oil or ginseng oil, and mixtures thereof.

[0021] In another aspect, the present invention provides a method for preparing a cosmetic composition according to the present invention, the method comprising: a. adding at least one kelp extract and at least one hydrolyzed hyaluronic acid salt to an aqueous solvent to form an aqueous phase; b. homogenizing the aqueous phase at room temperature to form a clear solution; and c. continuing to homogenize the solution for 10 to 30 minutes to obtain the cosmetic composition.

[0022] In another aspect, the present invention provides a cosmetic for controlling seborrhea, comprising a cosmetic composition according to the present invention.

[0023] In another aspect, the present invention provides a cosmetic composition according to the invention for non-therapeutic use in controlling seborrheic dermatitis.

[0024] In another aspect, the present invention provides a non-therapeutic method for controlling seborrhea, comprising applying a cosmetic composition or cosmetic according to the invention topically to the skin in need.

[0025] Other features and advantages of the present invention will become clearer when reading the following detailed description and embodiments.

Implementation Method

[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Where the definitions of terms in this specification conflict with the meanings commonly understood by one of ordinary skill in the art to which this invention pertains, the definitions set forth herein shall apply.

[0028] Except as described in the operational embodiments, or otherwise, all figures representing the amount of components and / or conditions should be understood to be modified in all cases by the term “about” having a meaning conventionally known in the art, for example, within 10% of the figures shown (e.g., “about 10%” means 9% to 11%, “about 2%” means 1.8% to 2.2%).

[0029] Furthermore, the range described in this invention and the claims is intended to specifically include the entire range, not just the endpoints. For example, the range of 0 to 10 is intended to disclose all integers between 0 and 10, such as 1, 2, 3, 4 and any subranges formed by any two of these values, all fractions between 0 and 10, such as 1.5, 2.3, 4.57, 6.1113 and any subranges formed by any two of these values, and the endpoints 0 and 10.

[0030] As used herein, the term “room temperature” refers to a temperature of approximately 20 to 25°C.

[0031] Unless otherwise stated, all parts or percentages in this invention refer to parts by weight or weight percentages.

[0032] According to a first aspect, the present invention relates to a cosmetic composition comprising at least one kelp extract and at least one hydrolyzed hyaluronic acid salt. According to one embodiment, the cosmetic composition of the present invention is used for topical application to the skin to control seborrhea and / or prevent acne.

[0033] Kelp Extract

[0034] According to a first aspect, the cosmetic composition of the present invention comprises at least one kelp extract.

[0035] The kelp extract suitable for use in the cosmetic compositions according to the present invention may be selected from kelp extract, palmate kelp extract, wedge-shaped kelp extract, seaweed extract, and mixtures thereof. Preferably, the kelp extract used in the cosmetic compositions of the present invention is kelp extract.

[0036] The cosmetic compositions of the present invention may contain a safe and effective amount of kelp extract, which is a brown algae extract. One example of kelp extract is sold by Biotech Marine (Seppic), France under the trade names Phlorogine and / or Phlorogine BG. Another suitable kelp extract is available from Ennagram, France via product code HG 657. Phlorogine is known as an anti-seborrheic agent that can regulate sebaceous gland activity, as described, for example, in U.S. Application Publication No. 2008 / 0119527A1. Methods for extracting brown algae are also known. European Patent No. 1074262B1 describes methods for extracting species of brown algae and kelp. These extracts are described as being used in cosmetic compositions as penetration protectants, free radical scavengers, or to combat the effects of skin aging. Commercially available kelp extracts may contain other compounds such as water, thickeners, humectants, solvents, and solubilizers. For example, Phlorogine and / or Phlorogine BG contain about 1% to about 2.5% of a dry extract (i.e., pure sugar kelp extract), with the remainder being an inert carrier.

[0037] Based on the total weight of the cosmetic composition, the cosmetic composition of the present invention may contain at least one kelp extract in an amount of about 0.0005% to about 5% based on dry weight, about 0.0008% to about 1% in one embodiment, and about 0.001% to about 0.1% based on another embodiment. For example, based on the total weight of the cosmetic composition, the kelp extract may be present in the cosmetic composition in an amount of about 0.0005%, about 0.0006%, about 0.0007%, about 0.0008%, about 0.0009%, about 0.001%, about 0.005%, about 0.01%, about 0.0125%, about 0.025%, about 0.05%, about 0.1%, about 0.5%, about 1%, about 2%, about 3%, about 4%, and about 5% based on dry weight.

[0038] Appropriate use of kelp extract is beneficial to the skin, such as moisturizing, skin soothing, regulating sebaceous gland activity, and anti-skin aging. When kelp extract is used in combination with at least one hydrolyzed hyaluronic acid salt, it exhibits a particularly synergistic effect in inhibiting lipid production, thus enabling promising applications for seborrheic control.

[0039] Hydrolyzed hyaluronic acid salt

[0040] According to a first aspect, the cosmetic composition of the present invention comprises at least one hydrolyzed hyaluronic acid salt.

[0041] Hydrolyzed hyaluronic acid salts are salts derived from hyaluronic acid. Hyaluronic acid (CAS No. 9004-61-9; structural formula 1) is a linear glycosaminoglycan composed of β4-glucuronic acid-β3-N-acetylglucosamine repeating disaccharides, with the molecular formula (C14H21NO11)n. Hyaluronic acid is a water-soluble substance and can be obtained in the form of high-purity lyophilized powder or aqueous solution. Hyaluronic acid can also exist in the form of its potassium or sodium salts (i.e., potassium hyaluronic acid or sodium hyaluronic acid). The molecular weight (MW) of hyaluronic acid in cosmetics varies greatly, ranging from 5 to 1800 kilodaltons (kDa), depending on the manufacturing process. Hyaluronic acid has a high water-retention capacity.

[0042] Structural Formula 1: Hyaluronic acid salt (when R is hydrogen = hyaluronic acid; when R is a metal cation = hyaluronic acid metal salt)

[0043] Hyaluronic acid salts of different molecular weights possess different physical and biological properties. Low molecular weight hyaluronic acid salts, also known as hydrolyzed hyaluronic acid salts (miniHA), refer to hyaluronic acid salts with a molecular weight not exceeding 1000 kDa (1 MDa). MiniHA's molecular size is too small to provide lubricity comparable to medium and high molecular weight hyaluronic acid salts, but it possesses greater biological activity. A series of in vitro and in vivo experimental results demonstrate that miniHA has significant effects such as deep moisturizing, repairing UV-damaged cells, scavenging free radicals, and anti-aging. Furthermore, compared to ordinary HA, miniHA has excellent transdermal absorption, thus exhibiting active efficacy in the epidermis and even the dermis, and can be used in moisturizing, repairing, and anti-aging products.

[0044] Preferably, the hydrolyzed hyaluronic acid salt suitable for use in the cosmetic compositions according to the present invention may be selected from hydrolyzed zinc hyaluronic acid (miniHA-Zn), hydrolyzed potassium hyaluronic acid (miniHA-K), hydrolyzed calcium hyaluronic acid (miniHA-Ca), and mixtures thereof. More preferably, the hydrolyzed hyaluronic acid salt used in the cosmetic compositions of the present invention is hydrolyzed zinc hyaluronic acid.

[0045] Hydrolyzed zinc hyaluronic acid is a hydrolysate derived from zinc hyaluronic acid (CAS No. 88103-59-7) through acid, enzymatic, or other methods, also known as hydrolyzed zinc hyaluronic acid salt. Typically, miniHA-Zn is obtained by exchanging sodium ions from hydrolyzed sodium hyaluronic acid with zinc ions from zinc salts. Commercially available hydrolyzed zinc hyaluronic acid products include, for example, those sold by Bloomage Biotechnology Co., Ltd. under the trade name "Hybloom™". MiniHA-Zn possesses functions such as moisturizing, inhibiting harmful bacteria on the skin, anti-inflammation, preventing skin wound infection, repairing damage, oil control, anti-aging, anti-oxidation, eliminating fine lines, and maintaining a healthy skin (including scalp) ecosystem.

[0046] Preferably, the molecular weight of the hydrolyzed hyaluronic acid salt suitable for use in the cosmetic composition according to the present invention is not more than 1 MDa, preferably 5 kDa to 500 kDa, more preferably 100 kDa to 300 kDa, for example 1 kDa to 5 kDa, 5 kDa to 10 kDa, 10 kDa to 200 kDa, 200 kDa to 500 kDa, 500 kDa to 1000 kDa.

[0047] Based on the total weight of the cosmetic composition, the cosmetic composition of the present invention may contain at least one hydrolyzed hyaluronic acid salt in an amount of about 0.0001% to about 5% by weight, in one embodiment about 0.0002% to about 1% by weight, and in another embodiment about 0.001% to about 0.05% by weight. For example, based on the total weight of the cosmetic composition, hydrolyzed hyaluronic acid salts may be present in the cosmetic composition in amounts of about 0.0001 wt%, 0.0002 wt%, about 0.0003 wt%, about 0.0004 wt%, about 0.0005 wt%, about 0.0006 wt%, about 0.0007 wt%, about 0.0008 wt%, about 0.0009 wt%, about 0.001 wt%, about 0.002 wt%, about 0.005 wt%, about 0.01 wt%, about 0.02 wt%, about 0.05 wt%, about 0.1 wt%, about 0.2 wt%, about 0.5 wt%, about 1 wt%, about 1.5 wt%, about 2 wt%, about 3 wt%, about 4 wt%, and about 5 wt%.

[0048] Appropriate use of hydrolyzed hyaluronic acid salts is beneficial for improving skin condition and appearance, and is particularly beneficial for skin moisturizing, oil control, cleansing, soothing, anti-oxidation, antibacterial, sun protection, damage repair, and improving skin barrier function. When hydrolyzed hyaluronic acid salts are used in combination with at least one kelp extract, they exhibit a synergistic effect in inhibiting lipid production, thus enabling promising applications for seborrhea control.

[0049] Not wishing to be bound by any particular theory, it is believed that certain kelp extracts and hydrolyzed hyaluronic acid salts exhibit some degree, but not a prominent, seborrhea control property. The inventors unexpectedly discovered that a combination of at least one kelp extract and at least one hydrolyzed hyaluronic acid salt exhibits a synergistic lipidogenesis inhibition effect, significantly superior to the additive sebum inhibition effect achieved by using either active ingredient alone. This enables the provision of a more effective solution for seborrhea control and / or acne prevention, particularly in cosmetic or dermatological applications.

[0050] In the cosmetic composition of the present invention, the weight ratio of kelp extract to hydrolyzed hyaluronic acid salt can be equal to or greater than 1:100, preferably about 1:10 to about 500:1, more preferably about 1:2 to about 100:1, and particularly preferably about 1:1 to about 40:1. For example, the weight ratio of kelp extract to hydrolyzed hyaluronic acid salt in the cosmetic composition is about 1:100, 1:90, 1:80, 1:70, 1:60, 1:50, 1:40, 1:30, 1:20, 1:15, 1:10, 1:9, 1:8, 1:7, 1:6, 1:5, 1:4, 1:3, 1:2, 1:1, 2:1, or 3:1. 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, 15:1, 20:1, 30:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1, 100:1, 150:1, 200:1, 250:1, 300:1, 350:1, 400:1, 450:1, 500:1.

[0051] An appropriate ratio of kelp extract to hydrolyzed hyaluronic acid salts is beneficial for a significant synergistic effect in inhibiting lipid production, thus enabling promising applications in seborrheic control.

[0052] Additional ingredients

[0053] The cosmetic composition of the present invention may be in solid, semi-solid, or liquid form, and may be in solution, emulsion, suspension, or anhydrous form. If in solution or suspension form, the cosmetic composition of the present invention may advantageously contain no more than 98% by weight, for example, 25% to 95% by weight, 30% to 90% by weight, or 35% to 85% by weight, relative to the total weight of the composition. If in emulsion form, the cosmetic composition of the present invention may contain 5% to 90% by weight, or 10% to 80% by weight, of water and 5% to 90% by weight, or 10% to 75% by weight, of oil relative to the total weight of the composition. If in anhydrous form, the cosmetic composition of the present invention may contain 10% to 99% by weight of oil and 10% to 99% by weight of a curing agent relative to the total weight of the composition.

[0054] To achieve the objectives of this invention, the cosmetic composition may also contain at least one cosmetically acceptable active ingredient, such as sugar derivatives, natural extracts, ferments, vitamins, urea, caffeine, salicylic acid and its derivatives, α-hydroxy acids and their derivatives, retinoids, niacinamide, humectants, sunscreens, peppermint oil, aloe vera oil, or ginseng oil, particularly active ingredients for preventing or reducing excess sebum, acne, wrinkles, fine lines, dry skin, photoaging, and inflammation. Other cosmetically acceptable ingredients that may be mentioned include antioxidants, fatty substances / oils, thickeners, emulsifiers, sunscreens, defoamers, humectants, fragrances, surfactants, fillers, chelating agents, anionic polymers, cationic polymers, nonionic polymers, or amphoteric polymers or mixtures thereof, propellants, acidifiers or alkalizers, dyes, colorants, pigments or nanopigments, or any other ingredients commonly formulated into cosmetics or pharmaceuticals. Non-limiting examples of some of these ingredients are provided in the following subsections.

[0055] A. Wetting agent

[0056] The compositions of the present invention may contain one or more humectants. If present, their range may be from about 0.1% to 75% by weight of the total composition, preferably from about 0.2% to 70%, more preferably from about 0.5% to 40%. Examples of suitable humectants include glycols, sugars, etc. Suitable glycols are in monomeric or polymeric form, including polyethylene glycol and polypropylene glycol, such as PEG 4-10, which is polyethylene glycol having 4 to 10 repeating ethylene oxide units; and C1-6 alkylene glycols, such as propylene glycol, butanediol, pentanediol, etc. Suitable sugars are also suitable humectants, some of which are also polyols. Examples of such sugars include glucose, fructose, honey, hydrogenated honey, inositol, maltose, mannitol, maltitol, sorbitol, sucrose, xylitol, xylose, etc. Urea is also suitable. Preferably, the humectant used in the compositions of the present invention is a C1-6, preferably C2-4 alkylene glycol, most particularly butanediol.

[0057] B. Plant extracts

[0058] The compositions of the present invention may also contain one or more plant extracts other than kelp extract. If present, the suggested range is about 0.0001% to 20% by weight of the total composition, preferably about 0.0005% to 15%, more preferably about 0.001% to 10%. Suitable plant extracts include extracts from plants (herbs, roots, flowers, fruits, seeds), such as flowers, fruits, vegetables, etc., including yeast fermentation extracts, Padina Pavonica extract, Thermus Thermophilis ferment extract, Camelina Sativa seed oil, Boswellia Serrata extract, olive extract, Acacia Dealbata extract, and Acer truncatum extract. Saccharinum (sugar maple), Acidopholus, Acorus, Aesculus, Agaricus, Agave, Agrimonia, algae, Aloe, Citrus, Brassica, Cinnamon, citrus, apple, blueberry, cranberry, peach, pear, lemon, lime, pea, seaweed, caffeine, green tea, chamomile, willow, mulberry, poppy, and those listed in the CTFA Cosmetic Ingredient Handbook, 8th edition, Volume 2, pages 1646-1660.Further specific examples include, but are not limited to, extracts of Glycyrrhiza Glabra, Salix Nigra, Macrocycstis Pyrifera, Pyrus Malus, Saxifraga Sarmentosa, Vitis Vinifera, Morus Nigra, Scutellaria Baicalensis, Anthemis Nobilis, Salvia Sclarea, Rosmarinus Officianalis, Citrus Limonum, Panax Ginseng, Siegesbeckia Orientalis, Fructus Mume, Ascophyllum Nodosum, Glycine Soja, beetroot extracts, Haberlea Rhodopensis, and Polygonum cuspidatum. Cuspidatum, sweet orange (Citrus Aurantium Dulcis), selaginella (Selaginella Tamariscina), hops (Humulus Lupulus), citrus peel (Citrus Reticulata), pomegranate (Punica Granatum), key algae (Asparagopsis), turmeric (Curcuma Longa), morning glory (Menyanthes Trifoliata), sunflower (Helianthus Annuus), barley (Hordeum Vulgare), cucumber (Cucumis Sativus), flat-branched husk (Evernia prunastri), powdery flat-branched husk (Evernia furfuracea), Sudan kola (Kola Acuminata) and mixtures thereof.

[0059] C. Surfactants

[0060] The compositions of the present invention may contain one or more surfactants, especially in the case of an emulsion. However, if the composition is a solution, suspension, or anhydrous composition, such surfactants may also be used. If present, the surfactant may range from about 0.001% to 30% by weight of the total composition, preferably from about 0.005% to 25%, more preferably from about 0.1% to 20%. Suitable surfactants may be siloxanes or organic nonionic, cationic, anionic, amphoteric, or zwitterionic.

[0061] Suitable nonionic surfactants include alkoxylated alcohols or ethers formed by the reaction of alcohols with alkylene oxides (typically ethylene oxide or propylene oxide). Suitable alcohols include mono-, di-, or poly- short-chain (C1-6) alcohols; aromatic or aliphatic saturated or unsaturated fatty (C12-40) alcohols; or cholesterol, etc. Cholesterol is suitable, or aromatic or aliphatic saturated or unsaturated fatty alcohols having 6 to 40, preferably about 10 to 30, more preferably about 12 to 22 carbon atoms. Examples include oleyl alcohol, cetearyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, betaine alcohol, etc. Examples of such ingredients include oleeth 2-100; steareth 2-100; beheneth 5-30; ceteareth 2-100; ceteth 2-100; and cholesterol 2-100, where the numerical range refers to the number of repeating ethylene oxide units. For example, ceteareth 2-100 refers to ceteareth with 2-100 repeating ethylene oxide units. Derivatives of alkoxylated alcohols are also suitable, such as their phosphate esters. Also suitable are alkoxylated alcohols formed with mono-, di-, or poly-short-chain alcohols, such as those having about 1 to 6 carbon atoms. Examples include glucose, glycerol, or their alkylated derivatives. Examples include glycereth 2-100; gluceth 2-100; methylglucose 2-100, etc. Other types of alkoxylated alcohols are suitable surfactants, including ethylene oxide polymers with different numbers of repeating EO groups, commonly known as PEG 12-200, such as PEG-75, which can be purchased from Dow Chemical under the trade name Carbowax PEG-3350.

[0062] Other suitable nonionic surfactants include alkoxylated sorbitol and alkoxylated sorbitol derivatives. For example, alkoxylation, particularly ethoxylation, of sorbitol provides polyalkoxylated sorbitol derivatives. Esterification of polyalkoxylated sorbitol provides sorbitol esters, such as polysorbate esters. For example, polyalkoxylated sorbitol can be esterified with C6-30, preferably C12-22 fatty acids. Examples of such components include polysorbate 20-85, sorbitol oleate, sorbitol sesquioleate, sorbitol palmitate, sorbitol sesquiisostearate, sorbitol stearate, and so on.

[0063] Various types of siloxane-based or silane-based surfactants are also suitable. Examples include organosiloxanes substituted with ethylene oxide or propylene oxide groups, such as PEG polydimethylsiloxanes, which are polyethylene glycol-substituted polydimethylsiloxanes, including those with INCI names such as PEG-1 polydimethylsiloxane; PEG-4 polydimethylsiloxane; PEG-8 polydimethylsiloxane; PEG-12 polydimethylsiloxane; PEG-20 polydimethylsiloxane, etc. Also suitable are silanes substituted with ethoxy or propoxy or both, such as various types of PEG methyl ether silanes, such as bis-PEG-18 methyl ether dimethylsiloxane, etc. Other examples of siloxane-based surfactants include those with the generic name polydimethylsiloxane copolyol; cetyl polydimethylsiloxane copolyol, etc.

[0064] D. Biomaterials

[0065] The compositions of the present invention may contain various types of biological materials, such as those derived from cells, fermentation materials, etc. If present, such materials may range from about 0.001% to 30% by weight of the total composition, preferably from about 0.005% to 25%, more preferably from about 0.01% to 20%. Examples include fragments of cellular RNA or DNA, or probiotic microorganisms.

[0066] E. Thickener

[0067] Suitable thickeners may be incorporated into the compositions of the present invention. If present, the suggested range is from about 0.01% to 30% by weight of the total composition, preferably from about 0.1% to 20%, more preferably from about 0.5% to 15%.

[0068] Examples of thickeners include animal waxes, plant waxes, mineral waxes, silicone waxes or synthetic waxes, with melting points ranging from about 30°C to 150°C. Examples of such waxes include waxes produced through Fischer-Tropsch synthesis, such as polyethylene or synthetic waxes; or various plant waxes, such as bayberry wax, candelilla wax, ozokerite, acacia wax, beeswax, ceresin, cetyl ester, flower wax, citrus wax, carnauba wax, jojoba wax, Japanese wax, polyethylene, microcrystalline wax, rice bran wax, lanolin wax, mink wax, montan wax, ouricury wax, palm kernel wax, paraffin wax, avocado wax, apple wax, shellac wax, clary wax, spent grain wax, and grape wax. beeswax), and its polyalkylene glycol derivatives (e.g., PEG6-20 beeswax or PEG-12 carnauba wax); or fatty acids or fatty alcohols, including their esters, such as hydroxystearic acid (e.g., 12-hydroxystearic acid), tristearate, tribehenin, etc.

[0069] Also suitable as thickeners are silica, silicates, methylsilyl silica and their alkali metal or alkaline earth metal derivatives. These silicates and silicates usually exist in particulate form, including silica, methylsilyl silica, magnesium aluminum silicate, etc.

[0070] Silicone elastomers can also be used as thickeners. Examples of suitable silicone elastomers for use in the compositions of the present invention may be in powder form, or dispersed or dissolved in solvents such as volatile or non-volatile silicones or silicone-compatible media such as paraffin hydrocarbons or esters. Examples of silicone elastomer powders include vinyl polydimethylsiloxane / polymethylsiloxane silsesquioxane crosslinked polymers, such as Shin-Etsu's KSP-100, KSP-101, KSP-102, KSP-103, KSP-104, and KSP-105; fluoroalkyl mixed silicone powders, such as Shin-Etsu's KSP-200, which is a fluorosiloxane elastomer; and phenyl mixed silicone powders, such as Shin-Etsu's KSP-300, which is a phenyl-substituted silicone elastomer; and Dow Corning's DC 9506. Examples of silicone elastomer powders dispersed in silicone compatibility media include polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymers supplied by various suppliers, including Dow Corning Corporation under the trade names 9040 or 9041, GE Silicones under the trade name SFE 839, and Shin-Etsu Silicones under the trade names KSG-15, KSG-16, and KSG-18. The CTFA name for KSG-15 is cyclopentylsiloxane / polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer. The INCI name for KSG-18 is phenyl polytrimethylsiloxane / polydimethylsiloxane / phenyl vinyl polydimethylsiloxane crosspolymer. Silicone elastomers are also available under the trademark Gransil from Grant Industries. Silicone elastomers having long-chain alkyl substituents are also suitable, such as lauryl polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymers supplied by Shin Etsu under the trade names KSG-31, KSG-32, KSG-41, KSG-42, KSG-43, and KSG-44. Crosslinked organic polysiloxane elastomers and methods for their preparation, which can be used in this invention, are further described in U.S. Patent No. 4,970,252, issued November 13, 1990, by Sakuta et al.; U.S. Patent No. 5,760,116, issued June 2, 1998, by Kilgour et al.; U.S. Patent No. 5,654,362, issued August 5, 1997, by Schulz, Jr. et al.; and Japanese Patent Application JP 61-18708, assigned to Pola Kasei Kogyo KK, each of which is incorporated herein by reference in its entirety.

[0071] Polysaccharides can be suitable aqueous thickeners. Examples of such polysaccharides include naturally derived materials such as agar, agarose, alcaligenes polysaccharide, alginate, alginic acid, gum arabic, amylopectin, chitin, dextran, cinnamon gum, cellulose gum, gelatin, gellan gum, hyaluronic acid, hydroxyethyl cellulose, methyl cellulose, ethyl cellulose, pectin, sclerotium gum, xanthan gum, pectin, trehalose, gelatin, etc.

[0072] Different types of synthetic polymer thickeners are also suitable. One type includes acrylic polymer thickeners composed of monomers A and B, wherein A is selected from acrylic acid, methacrylic acid, and mixtures thereof; and B is selected from C1-22 alkyl acrylate, C1-22 alkyl methacrylate, and mixtures thereof. Acrylic polymer solutions include those sold by Seppic, Inc. under the trade name Sepigel® or under the trade name Aristoflex®. Acrylic (ester) / stearyl polyether-20 methacrylate copolymers are also suitable, which are sold by Rohm & Haas under the trade name Acrysol ICS-1.

[0073] Equally suitable are acrylate-based anionic amphiphilic polymers containing at least one hydrophilic unit and at least one allyl ether unit containing an aliphatic chain. Such anionic amphiphilic polymers are described and prepared in U.S. Patents 4,677,152 and 4,702,844, which are incorporated herein by reference in their entirety. A commercial example of such polymers is a crosslinked terpolymer of methacrylic acid, ethyl acrylate, stearyl alcohol, polyethylene glycol (having 10 EO units) ether, or stearyl alcohol polyether-10, particularly those marketed by Allied Colloids under the names SALCARE SC80 and SALCARE SC90, which are aqueous emulsions containing 30% of a crosslinked terpolymer of methacrylic acid, ethyl acrylate, and stearyl alcohol polyether-10 allyl ether (40 / 50 / 10).

[0074] Also suitable are acrylate copolymers, such as polyacrylate-3, which is a copolymer of methacrylic acid, methyl methacrylate, methyl styrene isopropyl isocyanate and PEG-40 betaine monomers; polyacrylate-10, which is a copolymer of sodium acrylamide dimethyl taurate, sodium acrylate, acrylamide and vinylpyrrolidone monomers; or polyacrylate-11, which is a copolymer of sodium acrylamide dimethyl taurate, sodium acrylate, hydroxyethyl acrylate, lauryl acrylate, butyl acrylate and acrylamide monomers.

[0075] Equally suitable are acrylate-based crosslinked polymers, wherein one or more acrylate groups may have substituted long-chain alkyl groups (e.g., 6-40, 10-30, etc.), such as acrylate (ester) / C10-30 alkyl acrylate crosslinked polymers, which are copolymers of C10-30 alkyl acrylates and one or more monomers of acrylic acid, methacrylic acid, or simple esters thereof, crosslinked with allyl ethers of sucrose or pentaerythritol. Such polymers are commonly marketed under the trade names Carbopol or Pemulen and have the CTFA name carbomer.

[0076] A suitable type of aqueous thickener is an acrylate-based polymer thickener sold by Clariant under the trademark Aristoflex, such as Aristoflex AVC, which is an ammonium acrylamide taurate / VP copolymer; Aristoflex AVL, which is the same polymer found in AVC dispersed in a mixture containing caprylic / capric triglyceride, trilauryl polyether-4 and polyglycerol-2 sesquiisostearate; or Aristoflex HMB, which is an ammonium acrylamide taurate / benzyl alcohol polyether-25 methacrylate crosspolymer, etc.

[0077] Also suitable as thickeners are various polyethylene glycol (PEG) derivatives with a degree of polymerization ranging from 1,000 to 200,000. These components are indicated by the name "PEG" followed by thousands of degrees of polymerization, such as PEG-45M, which refers to PEG with 45,000 repeating ethylene oxide units. Examples of suitable PEG derivatives include PEG 2M, 5M, 7M, 9M, 14M, 20M, 23M, 25M, 45M, 65M, 90M, 115M, 160M, 180M, and so on.

[0078] Also suitable are polyglycerols with repeating glycerol portions, wherein the number of repeating portions ranges from 15 to 200, preferably from about 20 to 100. Examples of suitable polyglycerols include those with CTFA names such as polyglycerol-20, polyglycerol-40, etc.

[0079] F. Oil

[0080] When the composition of the present invention is in the form of a solution, suspension, anhydrous form, or especially an emulsion, the composition may contain an oil component. The oil component is desirable for skin moisturizing and protective properties. Suitable oils include silicone oils, esters, vegetable oils, and synthetic oils, including but not limited to those described herein.

[0081] The oil may be volatile or non-volatile, and is preferably a pourable liquid at room temperature. Suitable volatile oils typically have a viscosity in the range of about 0.5 to 5 centidodes at 25°C and include linear siloxanes, cyclic siloxanes, alkanes, or mixtures thereof. Cyclic and linear volatile siloxanes are available from various commercial sources, including Dow Corning Corporation and General Electric. Dow Corning linear volatile siloxanes are marketed under the trade names Dow Corning 244, 245, 344, and 200 fluids. These fluids include hexamethyldisilazane (viscosity 0.65 centidodes (cst)), octamethyltrisiloxane (1.0 cst), decamethyltetrasiloxane (1.5 cst), dodecylpentasiloxane (2 cst), and mixtures thereof, wherein all viscosity measurements are performed at 25°C. Suitable branched volatile siloxanes include alkyl polytrimethylsiloxanes, such as methyl polytrimethylsiloxane. Methyl polytrimethylsiloxane is available from Shin-Etsu Silicones under the trade name TMF-1.5, and has a viscosity of 1.5 centidodes at 25°C. Also suitable as volatile oils are various straight-chain or branched alkanes having 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 carbon atoms, more preferably 8 to 16 carbon atoms. Suitable hydrocarbons include pentane, hexane, heptane, decane, dodecane, tetradecane, tridecane, and C8-20 isoalkanes, as disclosed in U.S. Patents 3,439,088 and 3,818,105, which are incorporated herein by reference.

[0082] Various non-volatile oils are also suitable for the compositions of the present invention. Non-volatile oils typically have a viscosity greater than about 5 to 10 centipoise at 25°C, and the viscosity range at 25°C can be as high as about 1,000,000 centipoise. Examples of non-volatile oils include, but are not limited to, esters, hydrocarbon oils, glycerol esters of fatty acids, and non-volatile polysiloxanes.

[0083] Suitable esters are mono-, di-, and tri-esters. Examples of mono-ester oils that can be used in the compositions of the present invention include hexyl laurate, butyl isostearate, hexadecyl isostearate, hexadecyl palmitate, isostearyl neopentanoate, stearyl heptanoate, isostearyl isononanoate, stearyl lactate, stearyl octanoate, stearyl stearate, isononyl isononanoate, etc. Examples of di-ester oils that can be used in the compositions of the present invention include diisostearyl malate, neopentyl glycol dioctanoate, dibutyl sebacate, dicetylacetyl dilinoleate, dicetylacetyl adipate, diisocetylacetyl adipate, diisononyl adipate, diisostearyl dilinoleate, diisostearyl fumarate, diisostearyl malate, dioctyl malate, etc. Examples of triesters include esters of arachidonic acid, citric acid, or behenic acid, such as glyceryl triarachidate, tributyl citrate, triisostearyl citrate, triC12-13 alkyl citrate, tricaprylic acid glyceride, tricaprylyl citrate, tridecyl behenic acid, trioctyl dodecyl citrate, tridecyl behenic acid, or tridecyl cocoate, tridecyl isononanoate, etc. Esters suitable for use in the compositions of this invention are further described under the category of “Esters” in the CTFA Cosmetic Ingredient Dictionary and Handbook, 11th edition, 2006 (the text of which is incorporated herein by reference in its entirety).

[0084] Suitable non-volatile hydrocarbon oils include alkanes and alkenes, preferably those having more than about 20 carbon atoms. Examples of such hydrocarbon oils include C24-28 olefins, C30-45 olefins, C20-40 isoalkanes, hydrogenated polyisobutylene, polyisobutylene, polydecene, hydrogenated polydecene, mineral oil, pentahydrosqualene, squalene, squalane, and mixtures thereof. In a preferred embodiment, such hydrocarbons have a molecular weight in the range of about 300 to 1000 Daltons.

[0085] Synthetic or naturally occurring fatty acid glycerides or triglycerides are also suitable for the compositions. Both plant and animal sources may be used. Examples of such oils include castor oil, lanolin oil, C10-18 triglycerides, caprylic / capric / triglycerides, sweet almond oil, almond oil, sesame oil, flaxseed oil, tamanu seed oil, coconut oil, corn oil, cottonseed oil, linseed oil, black ink, olive oil, palm oil, sage oil, rapeseed oil, soybean oil, grapeseed oil, sunflower seed oil, walnut oil, etc. Also suitable are synthetic or semi-synthetic glycerides, such as glyceryl stearate, diisostearate, polyglyceryl isostearate-3, polyglyceryl isostearate-4, polyglyceryl ricinoleate-6, dioleoyl glyceride, diisostearate, tetraisostearate, tricaprylic acid glyceride, distearate, linoleic acid glyceride, glyceryl myristate, isostearate, PEG castor oil, PEG oleate, PEG stearate, PEG tallow glyceride, etc.

[0086] Both water-soluble and water-insoluble non-volatile silicone oils are also suitable for the composition. Examples of such silicone oils include polydimethylsiloxane, ammonia-terminated polydimethylsiloxane, phenyl polydimethylsiloxane, diphenyl polydimethylsiloxane, phenyl polytrimethylsiloxane, trimethylsiloxyphenyl polydimethylsiloxane, or alkyl polydimethylsiloxane such as cetyl polydimethylsiloxane. Phenyl polytrimethylsiloxane is available from Dow Corning Corporation under the trade name 556 Fluid. Trimethylsiloxyphenyl polydimethylsiloxane is available from Wacker-Chemie under the trade name PDM-1000. Cetyl dimethylsiloxane, also known as liquid silicone wax, can be purchased as Fluid 2502 from Dow Corning, or as Abil Wax 9801 or 9814 from DeGussa Care & Surface Specialties.

[0087] G. Sunscreen

[0088] It is also desirable to include one or more sunscreens in the compositions of the present invention. Such sunscreens include chemical UVA or UVB sunscreens or physical sunscreens in particulate form. Adding a sunscreen to a composition containing a whitening active ingredient will provide additional protection for the skin during the day and promote the effectiveness of the whitening active ingredient on the skin. If present, the sunscreen may range from about 0.1% to 50% by weight of the total composition, preferably from about 0.5% to 40%, more preferably from about 1% to 35%.

[0089] Examples of suitable UVA sunscreen compounds include 4-methyldiphenylmethane, 2-methyldiphenylmethane, 4-isopropyldiphenylmethane, 4-tert-butyldiphenylmethane, 2,4-dimethyldiphenylmethane, 2,5-dimethyldiphenylmethane, 4,4'-diisopropylbenzylmethane, 4-tert-butyl-4'-methoxydiphenylmethane, 4,4'-diisopropylbenzylmethane, 2-methyl-5-isopropyl-4'-methoxydiphenylmethane, 2-methyl-5-tert-butyl-4'-methoxydiphenylmethane, etc. Particularly preferred is 4-tert-butyl-4'-methoxydiphenylmethane, also known as avobenzone. Avobenzone can be purchased under the trademark Parsol® 1789 from Givaudan-Roure and under the trade name Eusolex® 9020 from Merck & Co. Other types of UVA sunscreens include dicamphor sulfonic acid derivatives, such as ecamsule, a sunscreen sold under the trade name Mexoryl®, which is terephthalimide dicamphor sulfonic acid.

[0090] The composition may contain about 0.001 to 20%, preferably 0.005 to 5%, more preferably about 0.005 to 3% of UVA sunscreen agent by weight of the composition.

[0091] Examples of suitable UVB sunscreen compounds include α-cyano-β,β-diphenylacrylate as described in U.S. Patent No. 3,215,724, which is incorporated herein by reference in its entirety. A specific example of α-cyano-β,β-diphenylacrylate is Octocrylene, which is 2-ethylhexyl 2-cyano-3,3-diphenylacrylate. If present, a suitable amount is about 0.001 to 10% by weight. Octocrylene is available from BASF under the trade name Uvinul® N-539.

[0092] Other suitable UVB sunscreens include benzylidene camphor derivatives as described in U.S. Patent No. 3,781,417, which is incorporated herein by reference in its entirety, such as 4-methylbenzylidene camphor, a fat-soluble UVB sunscreen compound marketed by Merck under the trade name Eusolex 6300. Also suitable are cinnamic acid ester derivatives, such as ethylhexyl methoxycinnamate, also known as octyl methoxycinnamate. This compound is available from Givaudan Corporation under the trade name Parsol® MCX or from BASF under the trade name Uvinul® MC 80.

[0093] Also suitable as UVB sunscreens are mono-, di-, and tri-ethanolamine derivatives of such methoxycinnamates, including diethanolamine methoxycinnamate. Cinoxate, and aromatic ether derivatives of the above compounds, are also acceptable. If present, the amount of cinoxate should not exceed about 3% by weight of the total composition.

[0094] Various benzophenone derivatives are also suitable as UVB sunscreens, such as benzophenone-3 (also known as hydroxybenzophenone), benzophenone-4 (also known as sulfoisobenzophenone), benzophenone-5 (sodium sulfoisobenzophenone), etc.

[0095] Also suitable as UVB sunscreen agents are certain salicylate derivatives, such as homomenthyl salicylate (also known as homosalyl) or mentholyl anthranilate. Homosalyl is available from Merck under the trademark Eusolex® HMS, and mentholyl anthranilate is available from Haarmann & Reimer under the trademark Heliopan®. If present, the amount of homosalyl should not exceed about 15% by weight of the total composition.

[0096] Also suitable as UVB sunscreens are various aminobenzoic acid derivatives, such as PABA, ethylhexyldimethylPABA (Padimate O), ethyl dihydroxypropylPABA, etc. If present, the amount of Padimate O should not exceed about 8% by weight of the total composition.

[0097] Salicylate derivatives are also acceptable UVB sunscreens. Such compounds include octyl salicylate, TEA-salicylate, DEA-salicylate, and mixtures thereof.

[0098] If present, the amount of UVB chemical sunscreen agent may be about 0.001 to 45% by weight of the total composition, preferably 0.005 to 40%, more preferably about 0.01 to 35%.

[0099] If desired, the compositions of the present invention can be formulated to have certain SPF (sun protection factor) values, ranging from about 1 to 50, preferably from about 2 to 45, and most preferably from about 5 to 30. The calculation of SPF values ​​is well known in the art.

[0100] H. Vitamins

[0101] It may be desirable to incorporate one or more vitamins into the compositions of the present invention. If present, the suggested range is from about 0.001% to 20% by weight of the total composition, preferably from about 0.005% to 15%, more preferably from about 0.010% to 10%. Preferably, such vitamins and / or vitamin derivatives are operable to scavenge free radicals in the form of singlet oxygen. Such vitamins may include tocopherols or derivatives thereof, such as tocopheryl acetate, tocopheryl ferulic acid ester, tocopheryl polyether-5, tocopheryl polyether-10, tocopheryl polyether-12, tocopheryl polyether-18, tocopheryl polyether-50, tocophersolan, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl succinate, dioleotocopheryl methylsilanol; ascorbic acid or derivatives thereof, such as palmitic ascorbate, magnesium ascorbate phosphate; vitamin A or derivatives thereof, such as retinyl palmitate; or vitamins D, K, B or derivatives thereof.

[0102] I. Antioxidants

[0103] Non-limiting examples of antioxidants that can be used in the compositions of the present invention include acetylcysteine, ascorbic acid polypeptide, ascorbate dipalmitate, ascorbate methylsilanol pectate, ascorbate palmitate, ascorbate stearate, BHA, BHT, tert-butylhydroquinone, cysteine, cysteine ​​salt, dipentylhydroquinone, di-tert-butylhydroquinone, diceryl thiodipropionate, disodium ascorbate sulfate, distearate thiodipropionate, ditridecyl thiodipropionate, gallate dodecyl ester, isoascorbic acid, ascorbate, ethyl ferulic acid, ferulic acid, gallate, hydroquinone, isooctyl mercaptoacetate, kojic acid. (acid), magnesium ascorbate, magnesium ascorbate phosphate, methylsilanol ascorbate, natural plant antioxidants (such as green tea or grape seed extract), nordihydroguaiac acid, octyl gallate, phenyl mercaptoacetic acid, potassium sulfite, propyl gallate, quinone, rosmarinic acid, sodium ascorbate, sodium bisulfite, sodium isoascorbate, sodium metabisulfite, sodium sulfite, superoxide dismutase, sodium mercaptoacetate, sorbitol furfural, thiodiethylene glycol, thiodiacetate, thiodiacetic acid, mercaptoacetic acid, mercaptolactic acid, thiosalicylic acid, and tris(nonylphenyl) phosphite.

[0104] J. Preservatives

[0105] Non-limiting examples of preservatives that can be used in the compositions of the present invention include quaternary ammonium preservatives, such as polyquaternary ammonium salt-1 and benzalkonium halide (e.g., benzalkonium chloride (“BAC”) and benzalkonium bromide), parabens (e.g., methylparaben and propylparaben), phenoxyethanol, benzyl alcohol, chlorobutanol, phenol, sorbic acid, thimerosal, or combinations thereof.

[0106] K. Pigment or nano pigment

[0107] The pigment is intended to impart a certain color to the composition before and / or after application to the skin, lips, and / or body growths. It may be desirable to incorporate one or more pigments into the compositions of the present invention. If present, the suggested range is from about 0.01% to 50% by weight of the total composition, preferably from about 1% to 25%, more preferably from about 2% to 15%. Examples of pigments suitable for use in the compositions of the present invention may be in the form of powders, granules, or microspheres, or dispersed or dissolved in a solvent. These pigments may be lakes, inorganic or organic pigments and / or pearlescent pigments or colorants. Preferred inorganic pigments are, for example, oxides of titanium, zirconium, or cerium, and oxides of zinc, iron, or chromium, and iron blue. Preferred organic pigments are, for example, carbon black and barium, strontium, calcium, and aluminum lakes. Preferred pearlescent agents are, for example, mica coated with titanium oxide, iron oxide, natural pigments, or bismuth oxychloride, such as colored titanium oxide-coated mica.

[0108] "Nano pigment" refers to a pigment in which the average size of the basic particles is 5 to 100 nm. Preferably, the average size of the basic particles of the nano pigment of the present invention is 10 to 50 nm.

[0109] L. Chelating agent

[0110] Non-limiting examples of chelating agents that can be used in the compositions of the present invention include ethylenediaminetetraacetic acid (EDTA), particularly disodium ethylenediaminetetraacetic acid and tetrasodium ethylenediaminetetraacetic acid, and their acidic forms; diethylenetriaminepentaacetic acid (DTPA) and its acidic forms; propylenediaminetetraacetic acid (PDTA) and its acidic forms; hydroxyethylethylenediaminetriacetic acid (HEDTA) and its acidic forms; tetrahydroxypropylethylenediamine; penterate salts, such as pentesodium penterate, and their acidic forms; etidronic acid. Salts, such as tetrasodium etidronate and its acid form; NTA salts and their acid forms; acrylic acid / acrylic acid methyl propane sulfonic acid copolymer polyacrylates and their acid forms; phosphonates and their acid forms; polyphosphates or metaphosphates and their acid forms; citrates as well as citric acid, galactosic acid and galactosic acid diacid; iminodisuccinates and their acid forms; zeolites; bentonite; layered disilates and their acid forms; N-acetylated ethylenediamine triacetate and its acid forms; phytic acid and phytates.

[0111] Other suitable ingredients that can be used in the compositions of the present invention include octyl glycol / phenoxyethanol / hexanediol, dioctyl carbonate, isopropyl isostearate, phenoxyethanol / octyl glycol, dextrin palmitate, magnesium sulfate, etc.

[0112] Those skilled in the art can select the amount of these ingredients based on the end use of the cosmetic composition. As will be understood by those skilled in the art, the composition according to the invention may contain about 20% to 98%, preferably about 30% to 90%, more preferably about 40% to 80% of one or more other cosmetically acceptable ingredients in total by weight of the composition.

[0113] The cosmetic compositions of the present invention may be in the form of liquid, lotion, thickened lotion, gel, cream, milk, ointment, paste, powder, makeup, or solid tube stick, and may optionally be packaged as aerosol, and may be provided in the form of mousse (e.g., aerosol mousse), foam or spray foam, spray, stick, gel, balm, powder, cleanser, soap, or aerosol or wipe.

[0114] Preferably, the cosmetic composition of the present invention is a topical composition, which is in the form of a suspension or dispersion in a solvent or fatty substance, or in the form of an emulsion or microemulsion (especially O / W or W / O type, O / W / O or W / O / W type), PET-emulsion, multiple emulsion, pickingering emulsion, hydrogel, alcohol gel, lipogel, single-phase or multi-phase solution or vesicle dispersion and other commonly used compositions, which can also be applied by pen, as a face mask or as a spray. The emulsion may also contain anionic, nonionic, cationic or amphoteric surfactants. Preferred compositions according to the present invention are skin care formulations, hair care formulations or functional formulations.

[0115] The amount of the cosmetic composition according to the invention to be applied to the skin depends on the concentration of the active ingredient in the composition and the desired cosmetic or pharmaceutical effect. For example, application may be by applying a cream to the skin. Typically, a cream is applied at an amount of 2 mg cream / cm² of skin. However, the amount of composition applied to the skin is not critical, and if a certain amount of the applied composition does not achieve the desired effect, a higher concentration of the active ingredient can be used, for example, by applying more of the composition or by applying a composition containing more active ingredients. The cosmetic composition according to the invention is preferably applied at least once daily, for example, twice or three times daily.

[0116] For information on the types of cosmetic compositions and their preparation, as well as other suitable additives, please refer to relevant literature, such as Novak GA, Die kosmetischen Präparate - Band 2, Die kosmetischen Präparate - Rezeptur, Rohstoffe, wissenschaftliche Grundlagen (Verlag für Chem. Industrie H. Ziolkowski KG, Augsburg).

[0117] Methods and Applications

[0118] According to a second aspect, the present invention relates to a method for preparing a cosmetic composition comprising at least one kelp extract and at least one hydrolyzed hyaluronic acid salt, comprising: a. adding at least one kelp extract and at least one hydrolyzed hyaluronic acid salt to an aqueous solvent to form an aqueous phase; b. homogenizing the aqueous phase at room temperature to form a clear solution; and c. continuing to homogenize the solution for 10 to 30 minutes to obtain the cosmetic composition.

[0119] Preferably, the aqueous solvent may contain water, and preferably contains at least 50% by weight, or at least 75% by weight, or at least 90% by weight, or at least 97% by weight, or at least 99% by weight of water relative to the total weight of the aqueous solvent. Optionally, in addition to water, the aqueous solvent may also contain one or more water-miscible solvents selected from monohydric alcohols, such as ethanol, particularly denatured ethanol; diols, such as ethylene glycol, propylene glycol (e.g., 1,3-propanediol), and butanediol (e.g., 1,3-butanediol), and mixtures thereof. The aqueous solvent may contain less than 50% by weight, or less than 25% by weight, or less than 10% by weight, or less than 3% by weight, or less than 1% by weight of water-miscible solvent relative to the total weight of the aqueous solvent.

[0120] According to a third aspect, the present invention relates to a method for controlling seborrhea, inhibiting lipid production processes, reducing sebum production in the skin, inhibiting lipid production in sebaceous gland cells of the skin, improving lipid levels in sebaceous gland cells of the skin, treating excessive sebum secretion and / or treating acne (or acne-prone) skin, said method comprising topically applying a cosmetic composition comprising at least one kelp extract and at least one hydrolyzed hyaluronic acid salt to the skin in need.

[0121] According to a fourth aspect, the present invention relates to the use of a cosmetic composition comprising at least one kelp extract and at least one hydrolyzed hyaluronic acid salt for controlling seborrhea, inhibiting lipid production processes, reducing sebum production in the skin, inhibiting lipid production in sebaceous gland cells of the skin, improving lipid levels in sebaceous gland cells of the skin, treating excessive sebum secretion and / or treating acne (or acne-prone) skin.

[0122] The present invention will be further described in conjunction with the following embodiments, which are presented for illustrative purposes and are not intended to be limiting in nature.

[0123] Example

[0124] The following embodiments are given for the purpose of illustrating the present invention and should not be construed as limiting the scope of the present invention.

[0125] The main raw materials used, their product names and suppliers are listed in Table 1.

[0126] [Table 1] Raw Materials Product Name INCI Name supplier 1,3 BUTYLENE GLYCOL Butylene glycol OQ CHEMICAL CORPORATION AMAZE XT Dehydroxanthan gum NOURYON SURFACE CHEMISTRY ARISTOFLEX AVC Ammonium acrylamide dimethyl taurate / VP copolymer CLARIANT BARGUARD CP / JEECIDE CAP-2 Octyl glycol / phenoxyethanol / hexanediol RML CETIOL CC dioctyl carbonate BASF ECO BRIJ S721 MBAL-PA (MH) Stearyl alcohol polyether-21 CRODA EDETA BD / DISODIUM EDTA Disodium EDTA BASF EMULIUM ILLUSTRO Polyglycerol-6 polyhydroxystearate / polyglycerol-6 polyricinoleate / polyglycerol-6 GATTEFOSSE GLYCERINE 99.7% USP KOSHER RSPO MB glycerin KOSHER HALLSTAR GMS PURE Glyceryl stearate THE HALLSTAR COMPANY HYBLOOM ZINC HYALURONATE Hydrolyzed zinc hyaluronic acid BLOOMAGE BIOTECHNOLOGY ISOPROPYL ISOSTEARATE Isopropyl isostearate ALZO NET-WO NS Polyglycerol-6 polyricinoleate / polyglycerol-2 isostearate / distearate dimethylammonium lithium montmorillonite BARNET OPTIPHEN Phenoxyethanol / Octoglycol ISP PHENOXETOL / OPTIPHEN PO Phenoxyethanol BASF PHLOROGINE Water / Butylene Glycol / Sugar Kelp Extract SEPPIC PMX-200-5CS / BELSIL DM 5 / DM-FLUID-A-6CS Polydimethylsiloxane DOW SILICONES CORPORATION Purified water Water\AQUA\EAU BASF RHEOPEARL KL2 Dextrin palmitate MIYOSHI AMERICA RONACARE MAGNESIUM SULFATE Magnesium sulfate AZELIS UK LIMITED SP MYRJ S100 MBAL PA (SG) PEG-100 stearate CRODA SP SPAN 83 MBAL-LQ-(AP) Sorbitol Sesquioleate UNIQEMA VANZAN NF Xanthan Gum VANDERBILT MINERALS ZEMEA SELECT PROPANEDIOL Propylene glycol DUPONT

[0127] Sample Preparation

[0128] Preparation of hydrolyzed zinc hyaluronic acid (miniHA-Zn) samples

[0129] Add 1 g of miniHA-Zn powder (Hybloom™ Zinc Hyaluronic Acid (HA-Zn), Bloomage, molecular weight ≤ 1.00 MDa, purity ≥ 91%) to 9 mL of purified water and place on a shaker for 30 minutes until completely dissolved to form a 10% stock solution. Store this stock solution at 4°C. Then, on the same day of treatment, dilute it to 0.001%, 0.002%, 0.004%, or 0.008% with complete cell culture medium.

[0130] Preparation of sugar kelp extract (LS extract) samples

[0131] 1 g Phlorogine (Seppic, containing 1.9% dry LS extract and the remainder inert carrier) was vortexed in 9 mL of purified water until completely dissolved to form a 10% stock solution. The stock solution was filtered and stored at 4°C. Then, on the day of treatment, it was diluted with complete cell culture medium to 0.125%, 0.25%, 0.5%, or 1% (corresponding to 0.002375%, 0.00475%, 0.0095%, or 0.019% of the LS extract).

[0132] Testing Method for Seborrhea Control Efficacy

[0133] 1. Cell Culture: Immortalized SZ95 human sebaceous gland cells derived from human facial sebaceous glands were cultured in a 5% CO2 humidified incubator at 37°C in Sebomed® basal medium (Sigma-Aldrich) supplemented with 10% fetal bovine serum (Corning), 1 mM CaCl2, 5 ng / mL recombinant human epidermal growth factor (Pufei, China), and 1% Antibiotic-Antimycotic (Gibco™, Thermo Fisher Scientific) (Zouboulis et al., 1999). The medium was changed every other day, and the cells were passaged at 60–80% confluence.

[0134] 2. Cell Treatment Cells were then isolated using TrypLE™ Express (Gibco) and seeded at a density of 10,000 cells / well into 96-well black / clear substrates (PE View plates). Cells were maintained overnight at 37°C and 5% CO2 in supplemented human sebaceous gland cell growth medium (Sigma, FB205). Cells were then treated for 72 hours with miniHA-Zn samples (0.001%, 0.002%, 0.004%, 0.008% in supplemented human sebaceous gland cell growth medium), LS extract samples (0.002375%, 0.00475%, 0.0095%, 0.019% in supplemented human sebaceous gland cell growth medium), or a combination of both.

[0135] 3. Lipid Production Inhibition Rate (%) After culture, cells were washed twice with DPBS buffer, and all cells were fixed in 4% paraformaldehyde for 5 minutes. Then, 100 μL of 1 μg / mL Nile Red (Sigma-Aldrich) phosphate-buffered saline solution was added to each well, and the cells were incubated at 37°C for 20 minutes. Fluorescence was measured on the Operetta CLS high-content imaging system (PE). Results are expressed as relative fluorescence units per cell. Neutral lipids were measured using an excitation wavelength of 485 nm and an emission wavelength of 565 nm, and polar lipids were measured using an excitation wavelength of 540 nm and an emission wavelength of 620 nm (Alestas et al., 2005). Nuclear DNA was labeled with DAPI (Invitrogen). The relative lipid production value was calculated using the following equation: Relative lipid production value % = (Average fluorescence intensity value of active product / Average fluorescence intensity value of control) × 100% Lipid production inhibition rate = 1 - Relative lipid production value %

[0136] The synergistic effects of the experimental results were evaluated using the isobole method as described in the article entitled “Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective” Medicina (Kaunas). 2019; 55(4):110, which is incorporated herein by reference in its entirety. According to the isobole method, OE represents the observed effect, and da and db represent the dose or concentration of active ingredient a and active ingredient b, respectively. Therefore, OE(da, db) represents the effect observed for the combination of active ingredient a at da and active ingredient b at db; OE(da) represents the effect observed for active ingredient a at da, and OE(db) represents the effect observed for active ingredient b at db. Three mathematical equations can be derived: OE(da, db) = OE(da) + OE(db) (Equation 1) OE(da, db) > OE(da) + OE(db) (Equation 2) OE(da, db) < OE(da) + OE(db) (Equation 3)

[0137] If the observed effect satisfies Equation 1, then the effect of the two active substances is a simple sum of individual effects, and the two active substances do not interact with each other, so there is no synergistic effect.

[0138] If the observed effect satisfies Equation 2, the result represents a true synergistic effect (or synergistic effect), in which the effect of the two active ingredients is greater than the simple sum of the effects of a single ingredient.

[0139] If the observed effect satisfies Equation 3, the result indicates the opposite effect of the synergistic effect, since the effect of the two active substances is less than the simple sum of the effects of a single substance.

[0140] The results of the seborrhea control efficacy are shown in Figures 1-2 and Tables 2-3, which demonstrate that active ingredient a (LS extract) and active ingredient b (miniHA-Zn) used in different concentrations and ratios exhibit a synergistic effect in lipidogenesis inhibition. The results in the same table represent experiments conducted on the same day using the same batch of cells. The synergistic effect between the LS extract and miniHA-Zn enables excellent seborrhea control efficacy at lower active ingredient concentrations.

[0141] [Table 2] Seborrhea control efficacy of Examples 1-5 Example No. LS extract da miniHA-Zn's db da : db Lipid production inhibition rate (OE(da) or OE(db) or OE(da, db)) Lipid production inhibition rate (OE(da) + OE(db)) 1 0.00475% - - 6% - 2 - 0.002% - -4% - 3 - 0.004% - -5% - 4 0.00475% 0.002% 2.375:1 8% 2% 5 0.00475% 0.004% 1.188:1 11% 1%

[0142] [Table 3] Seborrhea control efficacy of Examples 6-13 Example No. LS extract da miniHA-Zn's db da : db Lipid production inhibition rate (OE(da) or OE(db) or OE(da, db)) Lipid production inhibition rate (OE(da) + OE(db)) 6 0.0095% - - 12% - 7 0.019% - - 32% - 8 - 0.001% - -9% - 9* - 0.002% 1% - 10 - 0.008% 16% - 11 0.0095% 0.008% 1.188:1 43% 28% 12 0.019% 0.001% 19:1 33% twenty three% 13 0.019% 0.002% 9.5:1 44% 33% *Note: Due to differences in cell batches, the data on lipogenesis inhibition rate differs from the data in Example 2 in Table 2.

[0143] Preparation

[0144] Examples 14 to 27 were prepared according to the formulations shown in Tables 4 to 5.

[0145] [Table 4] Formulations of Examples 14-20 Product Name Ex. 14 Ex. 15 Ex. 16 Ex. 17 Ex. 18 Ex. 19 Ex. 20 Purified water Up to 100 Up to 100 Up to 100 Up to 100 Up to 100 Up to 100 Up to 100 HYBLOOM ZINC HYALURONATE 0.02 0.1 0.02 0.002 0.001 0.5 0.08 PHLOROGINE 1 1 0.6 1 1 0.5 4 1,3 BUTYLENE GLYCOL 1 1 1 1 1 1 1 AMAZE XT 0.3 0.3 0.3 0.3 0.3 0.3 0.3 BARGUARD CP / JEECIDE CAP-2 0.5 0.5 0.5 0.5 0.5 0.5 0.5 PHENOXETOL / OPTIPHEN PO 0.5 0.5 0.5 0.5 0.5 0.5 0.5

[0146] [Table 5] Formulations of Examples 21-26 Product Name Ex. 21 Ex. 22 Ex. 23 Ex. 24 Ex. 25 Ex. 26 Purified water Up to 100 Up to 100 Up to 100 Up to 100 Up to 100 Up to 100 HYBLOOM ZINC HYALURONATE 0.0025 0.05 0.005 0.2 0.02 0.1 PHLOROGINE 5 0.05 4 3 1 1 1,3 BUTYLENE GLYCOL 1 1 1 1 AMAZE XT 0.3 0.3 0.3 0.3 BARGUARD CP / JEECIDE CAP-2 0.5 0.5 0.5 0.5 PHENOXETOL / OPTIPHEN PO 0.5 0.5 0.5 0.5 RONACARE MAGNESIUM SULFATE 1 ZEMEA SELECT PROPANEDIOL 3 3 EDETA BD / DISODIUM EDTA 0.05 0.05 SP SPAN 83 MBAL-LQ-(AP) 1 EMULIUM ILLUSTRO 1.5 NET-WO NS 5 CETIOL CC 20 RHEOPEARL KL2 0.5 OPTIPHEN 0.5 GLYCERINE 99.7% USP KOSHER RSPO MB 5 HEAVENLY NF 0.1 ARISTOFLEX STROKE 0.5 ECO BRIDGE S721 MBAL-PA (MH) 0.5 SP MYRJ S100 BULLET (SG) 1.5 HALLSTAR GMS PURE 1 PMX-200-5CS / BELTSIL DM5 / DM-FLUIDS-A-6CS 5 ISOPROPYL ISOSTEARATE 5 BARGUARD CP / JEECIDE CAP-2 0.5

[0147] Although the invention and its advantages have been described in detail, it should be understood that various changes, substitutions, and modifications can be made herein without departing from the spirit and scope of the invention as defined by the appended claims. Furthermore, the scope of this application is not intended to be limited to the specific embodiments of the processes, apparatus, preparations, compositions of matter, devices, methods, and steps described in the specification. As will be readily understood by those skilled in the art from the invention, according to the invention, existing or later-developed processes, apparatus, preparations, compositions of matter, devices, methods, or steps can be utilized to perform substantially the same functions or achieve substantially the same results as the corresponding embodiments described herein. Therefore, the appended claims are intended to include such processes, apparatus, preparations, compositions of matter, devices, methods, or steps within their scope. [Simplified Explanation of the Diagram]

[0026] To better understand the present invention, reference is now made to the following specific embodiments in conjunction with the accompanying drawings, in which: Figure 1 is a bar graph showing the lipidogenesis inhibition effect of active ingredient a (LS extract) and active ingredient b (miniHA-Zn) at different concentrations (LS extract 0.00475%; miniHA-Zn 0.002% and 0.004%), used alone or in combination. Figure 2 is a bar graph showing the lipidogenesis inhibition effect of active ingredient a (LS extract) and active ingredient b (miniHA-Zn) at different concentrations (LS extract 0.0095% and 0.019%; miniHA-Zn 0.001%, 0.002%, and 0.008%), used alone or in combination.

Claims

1. A cosmetic composition comprising sucrose extract and hydrolyzed zinc hyaluronic acid.

2. The cosmetic composition as claimed in claim 1, wherein the molecular weight of the hydrolyzed zinc hyaluronic acid does not exceed 1 MDa.

3. The cosmetic composition of claim 1, wherein the hydrolyzed zinc hyaluronic acid has a molecular weight of 5 kDa to 500 kDa.

4. The cosmetic composition of claim 1, wherein the hydrolyzed zinc hyaluronic acid has a molecular weight of 100 kDa to 300 kDa.

5. The cosmetic composition of claim 1, wherein the weight ratio of the sugar kelp extract to the hydrolyzed zinc hyaluronic acid in the cosmetic composition is equal to or greater than 1:

100.

6. The cosmetic composition of claim 1, wherein the weight ratio of the sugar kelp extract to the hydrolyzed zinc hyaluronic acid in the cosmetic composition is from about 1:10 to about 500:

1.

7. The cosmetic composition of claim 1, wherein the weight ratio of the sugar kelp extract to the hydrolyzed zinc hyaluronic acid in the cosmetic composition is from about 1:2 to about 100:

1.

8. The cosmetic composition of claim 1, wherein the weight ratio of the sugar kelp extract to the hydrolyzed zinc hyaluronic acid in the cosmetic composition is from about 1:1 to about 40:

1.

9. The cosmetic composition of claim 1, wherein the sugar kelp extract is present in the cosmetic composition in an amount of about 0.0005% by weight to about 5% by weight based on the total weight of the cosmetic composition.

10. The cosmetic composition of claim 1, wherein the sugar kelp extract is present in the cosmetic composition in an amount of about 0.0008% by weight to about 1% by weight based on the total weight of the cosmetic composition.

11. The cosmetic composition of claim 1, wherein the sugar kelp extract is present in the cosmetic composition in an amount of about 0.001% by weight to about 0.1% by weight based on the total weight of the cosmetic composition.

12. The cosmetic composition of claim 1, wherein the hydrolyzed zinc hyaluronic acid is present in the cosmetic composition in an amount of about 0.0001% by weight to about 5% by weight, based on the total weight of the cosmetic composition.

13. The cosmetic composition of claim 1, wherein the hydrolyzed zinc hyaluronic acid is present in the cosmetic composition in an amount of about 0.0002% by weight to about 1% by weight, based on the total weight of the cosmetic composition.

14. The cosmetic composition of claim 1, wherein the hydrolyzed zinc hyaluronic acid is present in the cosmetic composition in an amount of about 0.001% by weight to about 0.05% by weight, based on the total weight of the cosmetic composition.

15. The cosmetic composition of claim 1, wherein, based on the total weight of the cosmetic composition, the cosmetic composition comprises about 0.001% to about 0.1% by weight of kelp extract and about 0.001% to about 0.05% by weight of hydrolyzed zinc hyaluronic acid on a dry weight basis, and wherein the weight ratio of kelp extract to hydrolyzed zinc hyaluronic acid is in the range of about 1:1 to about 40:

1.

16. A cosmetic composition as claimed in any one of claims 1 to 15, wherein the cosmetic composition further comprises at least one active ingredient selected from: natural extracts, ferments, vitamins, urea, caffeine, salicylic acid, alpha-hydroxy acids, retinoids, niacinamide, humectants, sunscreens, peppermint oil, aloe vera oil, or ginseng oil, and mixtures thereof; wherein the natural extracts include yeast fermentation extract, Padina Pavonica extract, Thermus Thermophilis fermentation extract, Camelina Sativa seed oil, Boswellia Serrata extract, olive extract, Acacia Dealbata extract, and Acer negundo extract. Saccharinum (sugar maple), Acidopholus, Acorus, Aesculus, Agaricus, Agave, Agrimonia, Algae, Aloe, Citrus, Brassica, Cinnamon, Citrus, Apple, Blueberry, Cranberry, Peach, Pear, Lemon, Lime, Pea, Seaweed, Green Tea, Chamomile, Willowbark, Mulberry, Poppy, Glycyrrhiza Glabra, Salix Nigra, Macrocycstis Pyrifera, Pyrus Malus, Saxifraga Sarmentosa, Vitis Vinifera, Morus Nigra, Scutellaria Baicalensis, Anthemis Nobilis, Salvia Sclarea, Rosmarinus Officianalis, Citrus Limonum, Panax Ginseng, Siegesbeckia Orientalis, Fructus Mume, Ascophyllum Nodosum, Glycine Soja extract, Beta Vulgaris, Haberlea Rhodopensis, Polygonum Cuspidatum, Citrus AurantiumDulcis, Selaginella Tamariscina, Humulus Lupulus, Citrus Reticulata peel, Punica Granatum, Asparagopsis, Curcuma Longa, Menyanthes Trifoliata, Helianthus Annuus, Hordeum Vulgare, Cucumis Sativus, Evernia Prunastri, Evernia Furfuracea, Kola Acuminata and mixtures thereof.

17. A method for preparing a cosmetic composition as described in any one of claims 1 to 16, comprising: a. Add sugar kelp extract and hydrolyzed zinc hyaluronic acid to an aqueous solvent to form an aqueous phase; b. Homogenize the aqueous phase at room temperature to form a clear solution; c. Continue to homogenize the solution for 10–30 minutes to obtain the cosmetic composition.

18. A cosmetic for controlling seborrhea, comprising a cosmetic composition as described in any one of claims 1 to 16.

19. The use of any cosmetic composition as claimed in any one of claims 1 to 16 in the manufacture of a medicament for the control of seborrheic dermatitis.

20. The use of the cosmetic composition as claimed in any one of claims 1 to 16 in the manufacture of a cosmetic for the control of seborrhea.

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