Hazardous pharmaceutical liquid-gas exchange devices

Abstract

A liquid-gas exchange device for hazardous pharmaceuticals includes a syringe, a first connector, a second connector, and a pressure equalization device. During drug dispensing, the collection section collects toxic gases, maintaining pressure balance between the internal and external atmospheric pressures of the vial or pouch. This also prevents small amounts of hazardous pharmaceuticals inside the vial or pouch from passing through the second connector in gaseous form or via atomization. During drug retrieval, the collection section collects and supplies clean air, maintaining pressure balance between the internal and external atmospheric pressures of the vial or pouch, and facilitating the removal of hazardous pharmaceuticals from the vial or pouch. Hazardous pharmaceuticals are blocked by a hydrophobic and breathable membrane, preventing them from passing through and entering the collection section.

Claims

1. A liquid-gas exchange device for hazardous pharmaceuticals, comprising: A syringe includes a syringe barrel, a plunger, and a piston. The plunger is disposed in the syringe barrel and has a plunger handle at its top. The piston is disposed at the bottom end of the plunger and is located in the syringe barrel. A first connector includes a body, a first coupling portion, a first needle, and a second needle. The body includes a sleeve and two first engaging portions. The sleeve has two first through holes. The first engaging portions are respectively located in the first through holes. The first coupling portion is disposed at the top of the sleeve and the bottom end of the syringe barrel. The first engaging portions connect to the first coupling portion. The first needle and the second needle are inserted into the first coupling portion. The second needle communicates with the interior of the syringe barrel. A second connector, which mates with or separates from the first connector, includes a base and a needle connector. The base includes an assembly portion and a puncture portion, and has a first flow channel and a second flow channel. The bottom end of the puncture portion has a pointed tip, and the first and second flow channels penetrate the bottom end of the puncture portion. The assembly portion includes a mounting base and a first stop. The first stop is disposed inside the mounting base and closes the openings of the first and second flow channels. The needle connector includes a housing, two second coupling portions, and a second... The housing includes a stop block, a housing having a second engaging portion located on the outside of the housing, second connecting portions located at the bottom of the housing, a second stop block located inside the housing, and a mounting base fixed to the second connecting portions; and a pressure balancing device including a guide portion, a collecting portion, and a hydrophobic and breathable membrane. The guide portion is located on the first connecting portion, a first needle communicates with the guide portion, the collecting portion communicates with the guide portion, and the hydrophobic and breathable membrane is located on the guide portion and / or the collecting portion; wherein, when the first connector mates with the pin connector, the first engaging portions are fixed to the second engaging portion, and the first needle and the second needle are inserted into the second stop block but do not penetrate the second stop block; and wherein, when the second connector moves upward, the first needle sequentially penetrates the second stop block and the first stop block and enters the first flow channel, and the second needle sequentially penetrates the second stop block and the first stop block and enters the second flow channel.

2. The hazardous pharmaceutical liquid-gas exchange device as described in claim 1, wherein, The first connecting part has a protrusion, the guiding part includes a tube body connected to the protrusion of the first connecting part, the interior of the tube body communicates with the interior of the first needle, the collecting part includes an outer cover and an airbag, the outer cover is integrally formed with one end of the tube body, the outer cover has a first chamber, the interior of the tube body communicates with the first chamber, the hydrophobic and breathable membrane is disposed in the first chamber and close to the opening of the tube body, and the airbag is disposed at the opening of the first chamber.

3. The hazardous pharmaceutical liquid-gas exchange device as described in claim 2, wherein, The pressure balancing device includes a check valve disposed on the outer cover to allow clean air from the outside space to enter the first chamber and to prevent air from flowing out of the first chamber.

4. The hazardous pharmaceutical liquid-gas exchange device as described in claim 1, wherein, The first flow channel surrounds the outside of the second flow channel.

5. The hazardous pharmaceutical liquid-gas exchange device as described in claim 1, wherein, The guide portion includes a tube body disposed on one side of the first joint portion. The interior of the tube body communicates with the interior of the first needle. The collection portion includes a filter integrally formed with one end of the tube body and has a second chamber. The interior of the tube body communicates with the second chamber. The hydrophobic and breathable membrane is disposed in the second chamber and is close to the opening of the tube body.

6. The hazardous pharmaceutical liquid-gas exchange device as described in any one of claims 1 to 5, wherein, The first joint is integrally formed with the top end of the sleeve and the bottom end of the syringe.

7. The hazardous pharmaceutical liquid-gas exchange device as described in any one of claims 1 to 5, wherein, The first connecting portion includes a first end and a second end. The first end is integrally formed with the top end of the sleeve. First engaging portions connect to the first end. The first and second tube pins are inserted into the first end. The first end has an outer peripheral wall, a plurality of teeth, and a plurality of sliders. The outer peripheral wall forms a receiving groove. The teeth are arranged around the inner side of the outer peripheral wall, and the sliders are arranged around the inner side of the outer peripheral wall and located above the teeth. The bottom of the second end is received in the receiving groove. In this configuration, the second end portion has a plurality of pawls and an annular groove. The pawls are arranged around the outer side of the bottom of the second end portion and engage with the teeth. The annular groove is arranged around the outer side of the bottom of the second end portion and is located above the pawls. The sliders are located in the annular groove. The top of the second end portion has an external thread, and a connector at the bottom end of the syringe has an internal thread. When the first end portion rotates along a first direction by a first rotational force, the first end portion... The first end is rotated along the first direction by the first rotational force, driven by the first rotational force, so that the top of the second end is fixed to the bottom of the syringe. After the top of the second end is fixed to the bottom of the syringe, when the first end rotates along the second direction opposite to the first direction by a second rotational force, the first end uses the teeth to press the pawls with the second rotational force, causing the pawls to bend and deform to disengage from the teeth, and the first end rotates freely relative to the second end along the second direction. After the top of the second end is fixed to the bottom of the syringe, when the first end rotates along the first direction by a third rotational force, the first end transmits the third rotational force to the pawls through the teeth. The third rotational force is greater than the force that the pawls can withstand, causing the pawls to break, allowing the second end to rotate arbitrarily relative to the first end along both the first and second directions.

8. A liquid-gas exchange device for hazardous pharmaceuticals, comprising: A syringe includes a syringe barrel, a plunger and a piston, the plunger being disposed in the syringe barrel and having a plunger handle at its top, and the piston being disposed at the bottom end of the plunger and located in the syringe barrel; A first connector is a movable closed connector, comprising a body, a first connecting part, and a first elastic valve. The body includes a sleeve, a guide tube, a positioning part, and two first engaging parts. The guide tube is disposed inside the sleeve and has a first channel and a first opening. The positioning part is located inside the sleeve and is disposed outside the guide tube. The first engaging parts are disposed outside the sleeve. The first connecting part is disposed at the top of the sleeve and the bottom of the syringe. The first elastic valve includes a first circumferential part and a first sealing part. The two ends of the first circumferential part are respectively disposed at the positioning part and the first connecting part. The first sealing part is located in the first channel. The top end of the first sealing part is connected to the inner side of the first circumferential part and has a plurality of perforations that communicate with the first channel. The bottom end of the first sealing part closes the first opening. A second connector is a snap-fit, closed needle-free connector module that mates with or separates from the first connector. It includes a base and a needle-free connector. The base includes an assembly portion and a puncture portion, and has a first flow channel and a second flow channel. The assembly portion has an assembly groove and a shaft hole. The second flow channel communicates with the shaft hole. The bottom end of the puncture portion has a pointed tip, and the first and second flow channels penetrate the bottom end of the puncture portion. The needle-free connector includes a housing, a second engagement portion, and a second elastic valve. The housing has a second engagement portion located on the outside of the housing. The top end of the housing has a second opening. The assembly part is located at the bottom end of the housing and is attached to the outside of the assembly part. The second elastic valve includes a second circumferential part and a second sealing part. The second circumferential part is located in the assembly groove and has a second channel. The second channel communicates with the shaft hole. The second sealing part is located inside the housing and has a slit. The second sealing part closes the second opening. The pressure balancing device includes a guide part, a collection part and a hydrophobic and breathable membrane. The guide part is located on the body and / or the base and communicates with the first flow channel. The collection part communicates with the guide part. The hydrophobic and breathable membrane is located on the guide part and / or the collection part. When the first connector mates with the pinless connector, the first engaging portion is fixed to the second engaging portion, the conduit compresses the second sealing portion, the second sealing portion compresses the second circumferential portion, causing the second sealing portion to move away from the second opening, and the conduit passes through the slit of the second sealing portion and enters the interior of the second sealing portion, the top of the housing abuts against the inner wall of the sleeve, the positioning portion moves along the conduit away from the pinless connector and compresses the first circumferential portion, causing the bottom end of the first sealing portion to disengage from the first opening, and the first channel communicates with the second channel;And wherein, when the first connector separates from the pinless connector, the first engaging portion disengages from the second engaging portion, the conduit disengages from the second sealing portion, causing the slit of the second sealing portion to close, the second sealing portion to reset and close the second opening by the elastic force of the second circumferential portion, the top of the housing disengages from the sleeve, and the positioning portion and the first sealing portion reset by the elastic force of the first circumferential portion, causing the bottom end of the first sealing portion to close the first opening.

9. The hazardous pharmaceutical liquid-gas exchange device as described in claim 8, wherein, The base has a protrusion, and the guide part includes a tube connected to the protrusion of the base. The interior of the tube communicates with the first flow channel. The collection part includes an outer cover and an airbag. The outer cover is integrally formed with one end of the tube. The outer cover has a first chamber. The interior of the tube communicates with the first chamber. The hydrophobic and breathable membrane is disposed in the first chamber and near the opening of the tube. The airbag is disposed at the opening of the first chamber.

10. The hazardous pharmaceutical liquid-gas exchange device as described in claim 8, wherein, The syringe further includes a cap disposed at the top of the syringe and having an air passage communicating with the interior of the syringe, such that the air passage and the interior of the syringe together form the collecting portion. A plunger passes through the cap, and the plunger handle is located above the cap. The inner diameter of the first end of the housing is larger than the outer diameter of the guide tube. The guide portion includes a tube and a filter. The top end of the tube is disposed on one side of the cap, and the bottom end of the tube is disposed on one side of the sleeve. The interior of the tube communicates with the air passage and the interior of the sleeve. The filter is disposed on one side of the base and has a second chamber, an inlet, and an outlet. The second chamber communicates with the inlet and the outlet. The inlet is connected to the first flow channel, the assembly part has a third flow channel, the outlet is connected to the third flow channel, the inner wall of the assembly tank has a fourth flow channel, the fourth flow channel is connected to the third flow channel, and the hydrophobic and breathable membrane is disposed in the second chamber; wherein, the hazardous drug liquid gas exchange device further includes a sealing ring, the sealing ring is disposed on the inner side of the sleeve and abuts against the top outer side of the housing or disposed on the top outer side of the housing and abuts against the inner side of the sleeve; wherein, when the first connector is mated with the needle-free connector, the interior of the sleeve is connected to the second opening, the second opening is connected to the interior of the housing, and the interior of the housing is connected to the fourth flow channel.

11. The hazardous pharmaceutical liquid-gas exchange device as described in claim 10, wherein, The cap has a protrusion on one side, and the protrusion of the cap opens the air passage. The top of the syringe has a groove on one side, and the protrusion of the cap is fixed in the groove. The top of the tube is connected to the protrusion of the cap. The sleeve has a protrusion on one side, and the bottom of the tube is connected to the protrusion of the sleeve.

12. The hazardous pharmaceutical liquid-gas exchange device as described in claim 8, wherein, The pressure balancing device includes a first hydrophobic and breathable membrane, a second hydrophobic and breathable membrane, and a check valve. The check valve is located on one side of the sleeve to allow clean air from the outside space to enter the sleeve and to prevent air from flowing out of the sleeve. The collection part includes an outer cover and an air bladder. The outer cover has a first chamber, and the air bladder is located at the opening of the first chamber. The guide part includes a tube and a filter. The tube is located on one side of the sleeve, and its interior communicates with the interior of the sleeve. The outer cover is integrally formed with one end of the tube, and the interior of the tube communicates with the first chamber. The first hydrophobic and breathable membrane is located in the first chamber and near the opening of the tube. The filter... The device is disposed on one side of the base and has a second chamber, an inlet, and an outlet. The second chamber communicates with the inlet and the outlet. The inlet communicates with the first flow channel. The assembly part has a third flow channel, and the outlet communicates with the third flow channel. The inner wall of the assembly groove has a fourth flow channel, which communicates with the third flow channel. The second hydrophobic and breathable membrane is disposed in the second chamber. The first connector further includes a sealing ring, which is disposed inside the sleeve and outside the housing. When the first connector is mated with the pinless connector, the interior of the sleeve communicates with the second opening, the second opening communicates with the interior of the housing, and the interior of the housing communicates with the fourth flow channel.

13. The hazardous pharmaceutical liquid-gas exchange device as described in claim 12, wherein, The sleeve has a protrusion on one side, and the tube body is connected to the protrusion of the sleeve.

14. The hazardous pharmaceutical liquid-gas exchange device as described in claim 10 or 12, wherein, The base has a first insertion part and a second insertion part on one side. The filter has an inlet end and an outlet end. The inlet end is inserted into the first insertion part and forms the inlet. The outlet end is inserted into the second insertion part and forms the outlet.

15. The hazardous pharmaceutical liquid-gas exchange device as described in claim 8, wherein, The outer side of the first joint is engaged with the inner side of the sleeve.

16. The hazardous pharmaceutical liquid-gas exchange device as described in claim 8, wherein, The outer side of the assembly is attached to the inner side of the housing.

17. The hazardous drug liquid gas exchange device as described in claim 8, further comprising a filter gas guide cover, the filter gas guide cover comprising a base, an outer ring wall, an inner ring wall, and a filter paper, the base having an accommodating groove, the outer ring wall and the inner ring wall being disposed on the base, the inner ring wall being located inside the outer ring wall, the height of the outer ring wall being greater than the height of the inner ring wall, the inner ring wall having a gas guide hole, the top of the inner ring wall having a protruding pushing portion, the gas guide hole penetrating the pushing portion and the base and communicating with the accommodating groove, the filter paper being disposed in the accommodating groove; wherein, When the first connector is connected to the filter air guide cover, the base and the outer ring wall abut against the sleeve, and the pushing part pushes the first sealing part to bend and deform, so that the bottom end of the first sealing part is separated from the first opening, and the first channel communicates with the air guide hole; wherein, when the first connector is separated from the filter air guide cover, the first sealing part returns to its original state and closes the first opening.

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