Synergistic composition of plant- and human-derived extracellular vesicles and its applications

Abstract

This invention provides an extracellular vesicle composition comprising plant extracellular vesicles and human extracellular vesicles, wherein the plant extracellular vesicles are derived from basil, calendula, ginger, and celery; and the human extracellular vesicles are derived from the human umbilical cord. This extracellular vesicle composition possesses antioxidant, anti-inflammatory, and cell repair and tissue regeneration promoting effects.

Claims

1. A composition of extracellular vesicles, comprising: a plant extracellular vesicle; and a human extracellular vesicle; wherein the concentration of the plant extracellular vesicle to the human extracellular vesicle is in a ratio of 1:10 to 1:1000; wherein, The plant extracellular vesicles were obtained from basil, marigold, or a combination of ginger and celery; the human extracellular vesicles were obtained from human umbilical cord, and the concentration of human extracellular vesicles was 10⁹~10 p / well; when the plant extracellular vesicles were basil, the concentration was 10⁸~9 p / well; when the plant extracellular vesicles were marigold, the concentration was 10⁸~9 p / well; when the plant extracellular vesicles were ginger, the concentration was 10⁷~8 p / well; and when the plant extracellular vesicles were celery, the concentration was 10⁷~8 p / well.

2. The extracellular vesicle composition as claimed in claim 1, wherein the plant extracellular vesicles are plant-derived extracellular vesicles (PDEVs).

3. The extracellular vesicle composition as described in claim 1, wherein the human extracellular vesicle is a human umbilical cord mesenchymal stem cell (UCMSC) exosome.

4. Use of an extracellular vesicle composition as described in any one of claims 1 to 3 for the preparation of a pharmaceutical composition having antioxidant, anti-inflammatory, cell repair-promoting, and tissue regeneration-promoting properties.

Images