New strains of Clostridium butyricum capable of producing butyric acid

Abstract

The present invention aims to provide a butyric acid bacterium that can be used more safely as an effective ingredient in intestinal regulators, etc. The present invention relates to a Clostridium butyricum that produces orthobutyric acid and has all the following characteristics (1) to (3): (1) it does not have the ability to assimilate D-xylose; (2) it does not have the ability to assimilate D-trehalose; (3) compared with the baseline strain of Clostridium butyricum NBRC13949T, the amount of formic acid produced in the culture medium after anaerobic culture at 37°C for 72 hours is less.

Claims

1. A Clostridium butyricum strain SIID29215-B6 (accession number: NITE BP-03916).

2. A Clostridium butyricum strain SIID49520-01-B1 (accession number: NITE BP-04190).

3. A Clostridium butyricum strain SIID50030-B1 (accession number: NITE BP-04191).

4. An intestinal regulating composition comprising, as an active ingredient, Clostridium butyricum cells, spores or culture medium as claimed in any one of claims 1 to 3.

5. A composition for inhibiting the growth of Clostridium difficile, comprising, as an active ingredient, the cells, spores or culture medium of Clostridium butyricum as claimed in any one of claims 1 to 3.

6. An anti-inflammatory composition comprising, as an active ingredient, Clostridium butyricum cells, spores or culture medium as claimed in any one of claims 1 to 3.

7. A composition for inducing regulatory T cells, comprising, as an active ingredient, Clostridium butyricum cells, spores or culture medium as claimed in any one of claims 1 to 3.

8. The components of claim 4 are in the form of a pharmaceutical product.

9. The components of claim 5 are in the form of a pharmaceutical product.

10. The components of claim 6 are in the form of a pharmaceutical product.

11. As in claim 7, the composition is in the form of a pharmaceutical product.

12. As in claim 4, the components are in the form of food or beverage.

13. As in claim 5, the composition is in the form of food or beverage.

14. As in claim 6, the composition is in the form of food or beverage.

15. As in claim 7, the composition is in the form of food or beverage.

Images