A method for preparing vitamin d2 using a microchannel reactor

Abstract

This disclosure provides a method for preparing vitamin D2 using a microchannel reactor, comprising: (a) dissolving ergosterol in a first solvent to form a first reaction solution; (b) passing the first reaction solution into a microchannel reactor, the microchannel reactor defining a first photoreaction zone irradiated by a first light source and a second photoreaction zone located downstream of the first photoreaction zone and irradiated by a second light source, such that as the first reaction solution passes through the first photoreaction zone and the second photoreaction zone, the first reaction solution is sequentially irradiated by the first light source and the second light source; (c) collecting and concentrating the first reaction solution irradiated by the second light source; (d) mixing the concentrated first reaction solution from step (c) with a second solvent as needed to form a second reaction solution; and (e) heating the first reaction solution from step (c) or the second reaction solution from step (d) to obtain vitamin D2.

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