Spraying device and spraying method

Abstract

A spraying apparatus and spraying method are disclosed. The spraying apparatus for spraying liquid onto a sprayed area includes a gas pressure source, a spray head, and a piping unit. The spray head is adapted to spray the liquid in a ring shape. The piping unit is connected between the gas pressure source and the spray head to provide liquid into the spray head. When the liquid is in the piping unit, the gas pressure source provides a first gas pressure to deliver the liquid in the piping unit to the spray head; when the liquid moves to the spray head, the gas pressure source provides a second gas pressure to spray the liquid in a ring shape through the spray head to the sprayed area.

Description

Technical Field

[0001] This disclosure relates to an apparatus and method, and more particularly to a spraying apparatus and spraying method. Prior Technology

[0002] An endoscope is a medical instrument that enters the human body through various natural openings to observe the internal condition of the body. When performing examinations and surgeries through an endoscope, it causes only minor damage to the body while achieving the same purpose as traditional open surgery, making it a commonly used diagnostic tool in modern medicine. The application scope of endoscopes includes the gastrointestinal tract, respiratory tract, urinary tract, female reproductive system, abdominal cavity, joint cavity, and thoracic cavity. Furthermore, minimally invasive surgery is also a common application of endoscopy, including procedures involving the spine, nasal cavity, and brain.

[0003] Through endoscopic examination, some minor internal wounds may only require the application of medication or cell spraying to treat, without the need for endoscopic surgery. However, some endoscopic surgeries require the application of medication or cell spraying to the affected area to accelerate recovery.

[0004] Therefore, the coverage rate of the sprayed medication on the affected area, the number of cells sprayed onto the affected area, and the survival rate are all factors that need to be considered in order to improve the treatment effect. Summary of the Invention

[0005] This disclosure provides a spraying device with good pesticide coverage and good cell survival rate.

[0006] This disclosure provides a spraying method to improve spraying effectiveness.

[0007] This disclosure discloses a spraying device for spraying liquid onto a sprayed area. The spraying device includes a gas pressure source, a spray head, and a piping unit. The spray head is adapted to spray the liquid in a ring shape. The piping unit is connected between the gas pressure source and the spray head to provide liquid into the spray head. When the liquid is in the piping unit, the gas pressure source provides a first gas pressure to deliver the liquid in the piping unit to the spray head; when the liquid moves to the spray head, the gas pressure source provides a second gas pressure to spray the liquid in a ring shape through the spray head to the sprayed area.

[0008] In one embodiment, the spray head includes a first swirl chamber, a fluid outlet, a second swirl chamber, and a turbine. The first swirl chamber is connected to a piping unit, the second swirl chamber is located between the first swirl chamber and the fluid outlet, and the turbine is disposed within the first swirl chamber.

[0009] In one embodiment, the ratio of the diameter of the fluid outlet to the total length of the first vortex chamber and the second vortex chamber is between 0.4 and 1.

[0010] In one embodiment, the ratio of the helical groove opening radius of the turbine to the helical radius of the turbine is between 1 and 5.0.

[0011] In one embodiment, the spraying device further includes a check valve disposed at one end of the spray head relatively close to the piping unit, wherein the check valve is located between the turbine and the piping unit.

[0012] In one embodiment, the opening and closing of the check valve is linked to the gas pressure source.

[0013] In one embodiment, the pressure value of the first gas pressure is less than the pressure value of the second gas pressure.

[0014] In one embodiment, the pressure value of the first gas pressure is between 0 and 10 kPa, while the pressure value of the second gas pressure is between 50 and 200 kPa.

[0015] In one embodiment, the liquid contains cells or a drug.

[0016] In one embodiment, the spraying device further includes a pipe connector, and the pipeline unit includes a first pipe and a second pipe, the first pipe being connected to a gas pressure source, the second pipe being connected to a spray head, and the pipe connector being connected between the first pipe and the second pipe, and liquid being adapted to enter the pipeline unit through the pipe connector.

[0017] In one embodiment, the pipe fitting is a tee or a directional valve.

[0018] A spraying method suitable for spraying liquid onto a spraying area includes at least the following steps: providing the spraying device described above; injecting liquid into a pipeline unit; when the liquid is in the pipeline unit, a gas pressure source provides a first gas pressure to deliver the liquid in the pipeline unit to a spray head; and when the liquid moves to the spray head, a gas pressure source provides a second gas pressure to spray the liquid in an annular pattern onto the spraying area via the spray head.

[0019] In one embodiment, the amount of liquid injected into the pipeline unit is 0.1 to 2 ml.

[0020] In one embodiment, the pressure value of the first gas pressure is less than the pressure value of the second gas pressure.

[0021] In one embodiment, the pressure value of the first gas pressure is between 0 and 10 kPa, while the pressure value of the second gas pressure is between 50 and 200 kPa.

[0022] In one embodiment, the liquid contains cells or a drug.

[0023] In one embodiment, the spraying method further includes providing a check valve at one end of the spray head that is relatively close to the piping unit, wherein the check valve is located between the turbine of the spray head and the piping unit to prevent liquid from flowing back into the piping unit.

[0024] In one embodiment, the opening and closing of the check valve is linked to the gas pressure source.

[0025] Based on the above, this disclosure provides a novel spraying device that can provide good drug spray coverage and cell survival rate, and the spraying method implemented by this spraying device can improve the spraying effect. Simple Explanation of the Diagram

[0026] Figure 1 is a schematic diagram of the spraying device according to an embodiment of this disclosure. Figure 2A is a cross-sectional view of the spray head and endoscope in the spraying device of Figure 1 within the inner annular wall. Figure 2B is a three-dimensional schematic diagram of the spray head in Figure 2A from another perspective. Figure 2C is a partial side view of the turbine in Figure 2B. Figure 2D is a cross-sectional view of the turbine in Figure 2C. Figure 3A is a schematic diagram showing that a check valve is also installed in the spray head. Figure 3B is a schematic diagram showing the deformation of the check valve caused by the gas pressure source pumping gas. Figures 4A to 4C are schematic diagrams of spraying methods using the spraying device shown in Figure 1. Figure 5 is a spray profile diagram of the spraying device shown in Figure 1 of this disclosure, compared with the spray profile diagram of the device without the present disclosure. Figure 6A is a schematic diagram comparing cell survival rates after spraying with different high-pressure gases according to an embodiment of this disclosure. Figure 6B is a schematic diagram comparing cell recovery rates after spraying with different high-pressure gases in one embodiment of this disclosure. Figure 6C is a schematic diagram showing the survival rate of cells after they have been sprayed and cultured according to an embodiment of this disclosure. Implementation

[0027] Figure 1 is a schematic diagram of the spraying device according to an embodiment of this disclosure. Referring to Figure 1, the spraying device 100 of this embodiment can be integrated into the endoscope 3 as an auxiliary medical device for the endoscope 3. Specifically, when using the endoscope 3 to examine internal organs such as the trachea, esophagus, lungs, intestines, and stomach, if the endoscope 3 observes minor wounds, inflamed areas, or areas requiring stem cell treatment, the spraying device 100 can spray liquid onto the area to be sprayed (or the affected area) for simple treatment. Alternatively, after some endoscopic surgeries, medications or cells can be sprayed onto the affected area to accelerate recovery. The liquid sprayed by the spraying device 100 may contain medications or cells (such as mesenchymal stem cells, MSCs) depending on the actual treatment needs. This treatment method replaces the medical method of swallowing anti-inflammatory, hemostatic, or wound-healing tablets. Specifically, the affected area can be, for example, the inner annular wall 2 of the trachea, but is not limited to this. This embodiment uses a spraying device 100 to spray liquid onto the affected area of ​​the inner annular wall 2 as an example. The spraying device 100 of this embodiment sprays liquid containing medication or cells in a circular motion onto the affected area of ​​the inner annular wall 2. The spraying device 100 can expel as much of the injected cells or medication as possible, effectively reducing the amount of liquid remaining inside the spraying device 100, and can effectively control the dosage or number of cells for each treatment, improving the precise dosage that enters the treated tissue.

[0028] As described above, the spraying device 100 of this embodiment includes a gas pressure source 110, a spray head 120, and a pipeline unit 130.

[0029] Piping unit 130 is connected between gas pressure source 110 and spray head 120. Piping unit 130 is used to provide liquid into spray head 120. Gas pressure source 110 is used to provide gas into piping unit 130 so that the liquid in piping unit 130 is pushed to spray head 120 and then sprayed out from spray head 120 in an annular spray pattern.

[0030] Specifically, the piping unit 130 includes a first pipe 131 and a second pipe 132, wherein the first pipe 131 is connected to the gas pressure source 110, and the second pipe 132 is connected to the spray head 120. To allow liquid to enter the piping unit 130, the spraying device 100 also includes a pipe connector 140 disposed within and communicating with the piping unit 130. The pipe connector 140 is connected between the first pipe 131 and the second pipe 132, and the pipe connector 140 can be a tee or a directional valve. Through the pipe connector 140, liquid can enter the piping unit 130.

[0031] Referring to Figure 1, the gas pressure source 110 described above can be a pump or a compressed air source, and the gas pressure it provides can be adjusted according to the liquid position. Specifically, in this embodiment, the gas pressure source 110 can be provided with a first gas pressure or a second gas pressure at an appropriate time by a microchip-controlled pump. In other embodiments, the first gas pressure and the second gas pressure can be provided by other means. For example, in one embodiment, gas can be injected through the syringe self-connector 140 to form the first gas pressure, while the second gas pressure is provided by the microchip-controlled gas pressure source 110. In another embodiment, gas can be injected through the syringe self-connector 140 to form the first gas pressure, while the second gas pressure is provided by compressed air passing through a pressure relief valve. In yet another embodiment, the first gas pressure and the second gas pressure can also be generated by compressed air passing through a pressure relief valve.

[0032] As described above, in this embodiment, when the liquid is in the second tube 132, the pressure value of the first gas pressure provided by the gas pressure source 110 is less than the pressure value of the second gas pressure provided by the gas pressure source 110 when the liquid is in the spray head 120.

[0033] Specifically, when liquid enters the piping unit 130 through the connector 140, the gas pressure source 110 provides a first gas pressure to the piping unit 130 to push the liquid into the second pipe 132 towards the spray head 120. Considering that the liquid may contain drugs or cells, a low-pressure gas is used to make the liquid in the second pipe 132 move as slowly as possible to prevent the cells from being damaged by shear force against the pipe wall of the second pipe 132. Conversely, when the liquid is at the spray head 120, since it is necessary to spray the liquid out quickly through the spray head 120, the gas pressure source 110 provides a second gas pressure to quickly spray the liquid out, and the sprayed liquid is sprayed out in a ring. In one embodiment, the pressure value of the first gas pressure is between 0 and 10 kPa; and the pressure value of the second gas pressure is between 50 and 200 kPa. The ranges for the first and second gas pressures listed herein are for illustrative purposes only and are not intended to limit the application of these ranges. Those skilled in the art can adjust the ranges of the first and second gas pressures according to actual needs. Furthermore, for ease of explanation, the first gas pressure will be referred to as low-pressure gas and the second gas pressure as high-pressure gas below.

[0034] By using low-pressure gas to slowly push the liquid into the spray head 120 in the second tube 132, not only can the shear force between the cells and the tube wall of the tubing unit 130 be reduced to prevent cell damage, but the survival rate of cells in the tubing unit 130 can also be greatly improved.

[0035] The aforementioned piping unit 130 may be made of Teflon, but is not limited thereto; it may also be made of plastic or other suitable materials. In one embodiment, the length of the piping unit 130 ranges from 0.5 to 2 meters, but is not limited thereto. Furthermore, in one embodiment, the volume of gas provided by the gas pressure source 110 ranges from 0.25 to 1 ml, but is not limited thereto. The gas volume is related to the length and diameter of the piping unit 130, and the gas volume provided by the gas pressure source 110, etc., and can be changed according to actual needs.

[0036] The volume of gas supplied by the gas pressure source 110 is related to the length of the pipeline unit 130. In other words, when the length of the pipeline unit 130 changes, the volume of gas supplied by the gas pressure source 110 to the pipeline unit 130 will also change.

[0037] Incidentally, the volume of gas supplied by the gas pressure source 110 is also related to the inner diameter of the piping unit 130, the material of the piping unit 130, and the surface roughness of the inner surface of the piping unit 130.

[0038] Figure 2A is a cross-sectional view of the spray head 120 and endoscope 3 within the inner annular wall 2 of the spraying device 100 in Figure 1, while Figure 2B is a perspective view of the spray head 120 from another angle. Referring simultaneously to Figures 1, 2A, and 2B, the spray head 120 includes a first vortex chamber 122, a fluid outlet 124d, a second vortex chamber 124c, and a turbine 126. The first vortex chamber 122 is connected to the piping unit 130; the second vortex chamber 124c is located between the first vortex chamber 122 and the fluid outlet 124d; and the turbine 126 is disposed within the first vortex chamber 122.

[0039] Specifically, the spray head 120 also includes a housing 124, wherein a first swirl chamber 122 and a second swirl chamber 124c are formed inside the housing 124, and a fluid outlet 124d is located at the second end 124b of the housing 124, which is relatively far away from the second tube 132.

[0040] The spray head 120 also includes an inlet connector 121 disposed within the housing 124, and the inlet connector 121 is disposed at one end of the housing 124 that connects to the second pipe 132, wherein the inlet connector 121 is used to position the turbine 126.

[0041] In this embodiment, the inlet connector 121 is annular, and the second pipe 132 is sleeved on the inlet connector 121. The inlet connector 121 is assembled to the end of the housing 124 that is relatively far from the fluid outlet 124d. It should be noted that the inlet connector 121 is provided to better align the second pipe 132 with the spray head 120 and to position the turbine 126 within the first vortex chamber 122. In another design, the inlet connector 121 can be integrally formed with the housing 124 inside the housing 124, depending on the requirements.

[0042] When liquid enters the spray head 120 from the second pipe 132 of the piping unit 130, the liquid enters the first vortex chamber 122 and flows through the turbine 126 before being sprayed out from the fluid outlet 124d through the second vortex chamber 124c. In particular, the liquid flowing through the turbine 126 generates multiple vortices due to the centrifugal force caused by the threads of the turbine 126. The number of vortices depends on the number of threads, and the multiple vortices mix in the second vortex chamber 124c before being sprayed out in an annular shape through the fluid outlet 124d.

[0043] In this embodiment, referring to Figure 2A, the diameter D1 of the first swirling chamber 122 is larger than the diameter D2 of the second swirling chamber 124c, and the diameter D2 of the second swirling chamber 124c is larger than the diameter D3 of the fluid outlet 124d. The larger diameter D1 of the first swirling chamber 122 compared to the diameter D2 of the second swirling chamber 124c is used to pressurize the liquid, allowing it to enter the second swirling chamber 124c more rapidly and mix quickly within it. The larger diameter D2 of the second swirling chamber 124c compared to the diameter D3 of the fluid outlet 124d is used to limit the spray angle when the liquid exits the fluid outlet 124d. Furthermore, the turbine 126's thread needs to rotate at least one revolution to achieve a good spraying effect, and the length of the second swirling chamber 124c is less than 1 / 3 of the length of the first swirling chamber 122, thus achieving a uniform annular spraying effect where the liquid mixes evenly within the second swirling chamber 124c.

[0044] In one embodiment, the ratio of the diameter of the fluid outlet 124d to the total length D4 of the first swirling chamber 122 and the second swirling chamber 124c is between 0.4 and 1. When the ratio is less than 0.4, the pressure during liquid spraying is too high and may easily damage the cells in the liquid. When the ratio is greater than 1, the turbine 126 may fall out of the fluid outlet 124d. Therefore, the aforementioned ratio makes the fluid outlet 124d large enough to reduce the pressure of the liquid flowing through the fluid outlet 124d. In addition to allowing the liquid to be sprayed out in a ring-shaped spray, it can also improve the survival rate of cells in the liquid after spraying and prevent cells from dying due to high pressure.

[0045] In this embodiment, referring to Figure 2A, to ensure that the sprayed liquid mist particles have an appropriate size, the diameter D2 of the second vortex chamber 124c is designed to be larger than its length Hm. For example, the ratio of the diameter D2 to the length Hm of the second vortex chamber 124c is approximately 1.6 to 3.8. In one embodiment, the diameter D2 of the second vortex chamber 124c is approximately 1.12 mm, while the length Hm is approximately 0.5 mm, and the ratio of diameter D2 to length Hm is 2.24.

[0046] In one embodiment, to facilitate smooth passage through the endoscope's working channel and considering the bend in the endoscope 3, the length Lt of the turbine 126 within the spray head 120 should be as short as possible. However, the turbine 126 needs at least two turns of its spiral to ensure sufficient airflow, and the diameter of the spray head 120 cannot be too large. Therefore, the appropriate ratio of the turbine 126's diameter Dt to its length Lt is approximately 0.8 to 1.0. In one embodiment, the turbine 126's diameter Dt is approximately 1.12 mm and its length Lt is approximately 1.28 mm, resulting in a ratio of 0.875.

[0047] Furthermore, the outer shell 121 of the spray head 120 and the turbine 126 disposed in the first vortex chamber 122 can be made of stainless steel, but are not limited thereto. Moreover, to improve cell viability and liquid spraying efficiency, a biocompatible and low-friction coating can be applied to the inner walls of the first vortex chamber 122 and the second vortex chamber 124c of the spray head 120 and to the surface of the turbine 126. The coating material can be, for example, parylene or PEDOT:PSS. Parylene provides long-lasting protection against enzymes, body fluids, lipids, and proteins, and has excellent barrier properties such as corrosion resistance and chemical resistance, thus also preventing other liquids from seeping in from the inner wall of the outer shell 124. PEDOT is a polymer of EDOT (3,4-ethylenedioxythiophene monomer), while PSS is polystyrene sulfonate; therefore, PEDOT:PSS has high conductivity and cell biocompatibility.

[0048] Figure 2C is a partial side view of the turbine 126 in Figure 2B, and Figure 2D is a cross-sectional view of the turbine 126 in Figure 2C along the diameter direction. Referring simultaneously to Figures 2A, 2C, and 2D, in one embodiment, the helical groove opening radius of the turbine 126 is designed to be approximately 48.89 degrees in one segment of the turbine 126, and the length of the segment is the length along the axial direction A of the turbine 126, which is approximately 1.28 mm. Furthermore, the ratio of the helical groove opening radius R1 relative to the center C of the turbine 126 to the helical portion radius R2 relative to the center C of the turbine 126 is between 1 and 5.0; for example, the angle corresponding to the helical groove opening radius R1 is 88 degrees and the angle corresponding to the helical portion radius R2 is 32 degrees. This design ensures that the helical groove opening radius R1 is large enough to reduce the pressure of the liquid passing through the turbine 126, preventing cell death due to high pressure, increasing the annular spray effect, and increasing the area of ​​liquid adhering to internal tissues. When the ratio is less than 1, excessive pressure will damage the cells, so liquid containing cells cannot be used; when the ratio is greater than 5, the wall thickness is too thin, which will affect the spraying effect.

[0049] Figure 3A is a schematic diagram showing that the spray head 120 is also equipped with a check valve 150. Referring to Figure 3A, in one embodiment, the spraying device 100 further includes a check valve 150 disposed at the first end 124a (shown in Figure 2A) of the housing 124 of the spray head 120 and connected to the inlet connector 121. The check valve 150 may be made of silicone, but is not limited thereto. The check valve 150 can prevent cell leakage during low-pressure pre-injection of gas to increase cell recovery rate; and during high-pressure spraying of liquid, it can prevent external body fluids from flowing back into the pipeline unit 130, avoiding contamination of the pipeline unit 130 and increasing the survival rate of cells in the pipeline unit 130.

[0050] In one embodiment, the check valve 150 is made of a flexible material and is generally arc-shaped, with a cutout 151 at the top of the arc. The cutout 151 can be straight, cross-shaped, or other suitable shapes. In this embodiment, the cutout 151 of the check valve 150 is cross-shaped.

[0051] The check valve 150 is linked to the gas pressure source 110 and is deformed by the gas pumped by the gas pressure source 110, so as to spray the liquid into the first vortex chamber 122 through the cut 151.

[0052] Figure 3B is a schematic diagram showing the deformation of the check valve caused by the gas pressure source pumping gas. When the gas pressure source 110 pumps low-pressure gas, the check valve 150 deforms slightly and the gas slowly leaks out from the cut 151 of the check valve 150, as shown in Figure 3A; when the liquid enters the inlet connector 121 of the spray head 120, the gas pressure source 110 pumps high-pressure gas, and the check valve 150 is affected by the high-pressure gas and undergoes a large deformation, and the liquid sprays out from the cut 151 into the first vortex chamber 122, as shown in Figure 3B.

[0053] Incidentally, the leading edge of the check valve 150 and the turbine 126 need to be spaced a certain distance apart in order for the liquid to flow smoothly into the threads of the turbine 126, wherein the distance between the leading edge of the check valve 150 and the turbine 126 is at least about 1 mm.

[0054] Figures 4A to 4C are schematic diagrams of spraying methods performed using the spraying device 100 of Figure 1. As shown in Figure 4A, when the spraying method is performed using the spraying device 100 described above, approximately 0.25 ml of liquid 4 is injected into the pipeline unit 130 through the pipe connector 140.

[0055] Next, as shown in Figure 4B, the gas pressure source 110 provides 0.5 ml of low-pressure gas to move the liquid 4 in the pipeline unit 130, causing the liquid 4 to slowly advance towards the spray head 120. In this embodiment, the pressure value of the first gas pressure is between 0 and 10 kPa.

[0056] In one embodiment, a first gas pressure (low-pressure gas) is provided to move the cell-containing liquid 4 such that the residual liquid on the wall of the piping unit 130 is less than that without using low-pressure gas to move the cell-containing liquid 4 within the piping unit 130. Furthermore, by providing low-pressure gas to move the cell-containing liquid 4, the cell survival rate and recovery rate are superior to those without using low-pressure gas to move the cell-containing liquid 4 within the piping unit 130.

[0057] Next, as shown in Figure 4C, when the liquid 4 moves to the spray head 120, the gas pressure source 110 provides a second gas pressure (high-pressure gas) between 50 and 150 kPa to spray the liquid 4 out of the spray head 120.

[0058] In one embodiment, due to the structural design of the spray head 120, the liquid spraying effect is excellent, avoiding the situation where the liquid drips out in the form of water droplets.

[0059] Figure 5 compares the spray profile produced by the spraying device 100 of Figure 1 with that produced by a conventional spraying device 100. As can be seen from Figure 5, without the spray head 120, the liquid is directly sprayed, resulting in a smaller spray area and a spray profile with an outer ring diameter of less than 3 mm. However, with the spray head 120, the spraying device 100 of this disclosure can form an annular spray profile with an outer ring diameter of approximately 25 mm. Therefore, it is more suitable for situations requiring annular spraying, such as the trachea and gastrointestinal tract, and increases the area of ​​liquid sprayed on the affected area. In one embodiment, the angle of the liquid sprayed from the fluid outlet 124d by the spraying device 100 of this disclosure is between 40 and 70 degrees.

[0060] In addition, the cell survival rate, recovery rate and cell survival rate after 16-18 hours of culture were verified by applying high-pressure gas at different pressures during spraying.

[0061] Specifically, the cell-containing liquid was sprayed out with high-pressure gas at 100 kPa and 80 kPa respectively, and high-pressure gas (such as air) was applied twice within 6 seconds. The survival rate of the first cell and the cell recovery rate in the sprayed liquid were observed.

[0062] To further assess the damage caused to cells by high-pressure spraying, the sprayed liquid was cultured for 16-18 hours. After the culture was completed, the number of surviving cells was calculated using a cell fluorescence counter and compared with the number of cells before spraying to obtain a second cell survival rate.

[0063] Figure 6A is a schematic diagram comparing the first cell survival rate of cells in a liquid after spraying with different high-pressure gases. As shown in Figure 6A, the cell survival rate before spraying can reach 91.5%, while the first cell survival rate after spraying with high-pressure gases of 100 kPa and 80 kPa respectively can still be greater than 88%.

[0064] Figure 6B is a schematic diagram comparing the cell recovery rates in liquid after spraying with different high-pressure gases. As shown in Figure 6B, the cell recovery rate is greater than 82% after spraying with high-pressure gases of 100 kPa and 80 kPa, respectively.

[0065] Figure 6C is a schematic diagram of the second cell survival rate after the cells in the liquid are sprayed out and cultured. As shown in Figure 6C, after spraying with high-pressure gas of 100 kPa and 80 kPa respectively, the second cell survival rate is still greater than 97% after 16-18 hours of cell culture.

[0066] As can be seen from the above, using the spraying device 100 disclosed herein for ring spraying can avoid problems such as poor cell survival rate.

[0067] In summary, the spraying device disclosed herein features a novel architecture and provides excellent spray coverage and cell survival rate. This disclosure reduces the required liquid volume during implementation and increases the uniformity of adhesion to the treatment area (such as lung tissue), thereby increasing the number of cells remaining on the vessel wall of the affected area and enhancing the spraying and therapeutic effects.

[0068] 100: Spraying device 110: Gas pressure source 120: Sprayer head 121: Inlet connector 122: First vortex chamber 124: Outer shell 124a: First end 124b: Second end 124c: Second vortex chamber 124d: Fluid outlet 126: Turbo 130: Piping Unit 131: First tube 132: Second tube 140: Pipe fitting 150: Check valve 151: Incision 2: Inner annular wall 3: Endoscopy 4: Liquid D1, D2, D3, Dt: Diameter D4: Total Length Hm: Length Lt: Length R1: Spiral groove opening radius R2: Curvature of the spiral section A: Axial C: Center

Claims

1. A spraying device for spraying a liquid onto a sprayed area, comprising: A gas pressure source; A spray head suitable for spraying the liquid in a ring shape; A pipeline unit is connected between the gas pressure source and the spray head to provide the liquid into the spray head; wherein when the liquid is in the pipeline unit, the gas pressure source provides a first gas pressure to deliver the liquid in the pipeline unit to the spray head; when the liquid moves to the spray head, the gas pressure source provides a second gas pressure to spray the liquid in a ring shape through the spray head to the area to be sprayed, wherein the pressure value of the first gas pressure is less than the pressure value of the second gas pressure.

2. The spraying device as claimed in claim 1, wherein the spray head comprises: A first vortex chamber, connected to the piping unit; a fluid outlet; A second vortex chamber is located between the first vortex chamber and the fluid outlet; and a turbine is disposed within the first vortex chamber.

3. The spraying device as claimed in claim 2, wherein the ratio of the diameter of the fluid outlet to the total length of the first vortex chamber and the second vortex chamber is between 0.4 and 1.

4. The spraying device as claimed in claim 2, wherein the diameter of the first vortex chamber is larger than the diameter of the second vortex chamber, and the diameter of the second vortex chamber is larger than the diameter of the fluid outlet.

5. The spraying device as claimed in claim 2, wherein the ratio of the radii of the spiral groove opening of the turbine to the radii of the spiral portion of the turbine is between 1 and 5.

0.

6. The spraying device as claimed in claim 2 further includes a check valve disposed at one end of the spray head relatively close to the piping unit, wherein the check valve is located between the turbine and the piping unit.

7. The spraying device as claimed in claim 6, wherein the opening and closing of the check valve is linked to the gas pressure source.

8. The spraying device as claimed in claim 1, wherein the pressure value of the first gas pressure is between 0 and 10 kPa, and the pressure value of the second gas pressure is between 50 and 200 kPa.

9. The spraying device as claimed in claim 1, wherein the liquid contains cells or a pharmaceutical agent.

10. The spraying device as claimed in claim 1 further includes a pipe connector, and the piping unit includes a first pipe and a second pipe, the first pipe being connected to the gas pressure source, the second pipe being connected to the spray head, and the pipe connector being connected between the first pipe and the second pipe, wherein the liquid is adapted to enter the piping unit through the pipe connector.

11. The spraying device as claimed in claim 10, wherein the pipe fitting is a tee or a directional valve.

12. A spraying method suitable for spraying a liquid onto an area to be sprayed, comprising: Provide a spraying device as claimed in claim 1; inject a liquid into the piping unit; wherein when the liquid is in the piping unit, the gas pressure source provides a first gas pressure to deliver the liquid in the piping unit to the spray head; and when the liquid moves to the spray head, the gas pressure source provides a second gas pressure to spray the liquid in an annular pattern to the area to be sprayed via the spray head.

13. The spraying method as described in claim 12, wherein the amount of liquid injected into the pipeline unit is 0.1 to 2 ml.

14. The spraying method as claimed in claim 12, wherein the pressure value of the first gas pressure is less than the pressure value of the second gas pressure.

15. The spraying method as claimed in claim 14, wherein the pressure value of the first gas pressure is between 0 and 10 kPa, and the pressure value of the second gas pressure is between 50 and 200 kPa.

16. The spraying method as described in claim 12, wherein the liquid contains cells or a pharmaceutical agent.

17. The spraying method as claimed in claim 12, further comprising providing a check valve at one end of the spray head relatively close to the pipeline unit, wherein the check valve is located between a turbine of the spray head and the pipeline unit to prevent the liquid from flowing back into the pipeline unit.

18. The spraying method as described in claim 17, wherein the opening and closing of the check valve is linked to the gas pressure source.

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