Slow-release hydrogel dressing for promoting wound healing and method for manufacturing the same

Abstract

This invention discloses a sustained-release hydrogel dressing that promotes wound healing and its manufacturing method. The sustained-release hydrogel dressing includes a substrate layer, a hydrogel absorbent layer, and a hydrogel dressing layer formed on the substrate layer. The hydrogel absorbent layer has a first surface away from the substrate layer and a second surface opposite to the first surface. The first surface serves as the contact surface of a wound. The hydrogel dressing layer is disposed between the second surface and the substrate layer. The hydrogel dressing layer is formed in a mesh-like structure and contains a bioactive ingredient. The hydrogel absorbent layer is formed in a foam-like structure and does not contain the bioactive ingredient, so that when absorbing exudate from the wound, the bioactive ingredient is driven to migrate towards the first surface by a concentration difference.

Claims

1. A sustained-release hydrogel dressing that promotes wound healing, comprising a substrate layer, a hydrogel absorbent layer, and a hydrogel dressing layer formed on the substrate layer, the hydrogel absorbent layer having a first surface away from the substrate layer and a second surface opposite to the first surface, the first surface serving as a contact surface for a wound, and the hydrogel dressing layer disposed between the second surface and the substrate layer; wherein, The hydrogel dressing layer is formed in a mesh shape, with the mesh being N-sided and N≧3; and the hydrogel dressing layer contains a bioactive ingredient; wherein, the hydrogel absorbent layer is formed in a foam shape and does not contain the bioactive ingredient, thereby the bioactive ingredient is driven to migrate to the first surface by the concentration difference between the hydrogel absorbent layer and the hydrogel dressing layer; wherein, the bioactive ingredient is a cell or a cell-secreting factor; the cell is a mesenchymal stem cell, a fibroblast, or a combination thereof, and the cell-secreting factor is selected from the group consisting of growth factors, extracellular matrix, exosomes, thrombin, and secretory proteome.

2. The sustained-release hydrogel dressing as described in claim 1, wherein, The hydrogel dressing layer has a multi-layer structure, and the upper and lower layers of the multi-layer structure have an alternating grid distribution.

3. The sustained-release hydrogel dressing as described in claim 2, wherein, The mesh density of the upper layer is greater than that of the lower layer.

4. The sustained-release hydrogel dressing as described in claim 1, wherein, The thickness of the hydrogel absorbent layer is in the range of 0.5 mm to 5 mm, and the thickness of the hydrogel dressing layer is in the range of 0.5 mm to 5 mm.

5. The sustained-release hydrogel dressing as claimed in claim 1 further includes a dressing carrier and a release liner, wherein the hydrogel absorbent layer and the hydrogel dressing layer are supported on the dressing carrier via the substrate layer, and the release liner covers the hydrogel absorbent layer.

6. A method for preparing a sustained-release hydrogel dressing that promotes wound healing, comprising: Provide a substrate layer; A hydrogel absorbent layer and a hydrogel dressing layer are formed on the substrate layer. The hydrogel absorbent layer has a first surface away from the substrate layer and a second surface opposite to the first surface. The first surface serves as the contact surface of a wound. The hydrogel dressing layer is disposed between the second surface and the substrate layer. The hydrogel dressing layer is formed in a mesh shape, with an N-sided mesh (N ≥ 3). The hydrogel dressing layer contains a bioactive ingredient. The hydrogel absorbent layer is formed in a foam shape and does not contain the bioactive ingredient, thereby driving the bioactive ingredient to migrate towards the first surface due to the concentration difference between the hydrogel absorbent layer and the hydrogel dressing layer. The bioactive ingredient is a cell or a cell-secreting factor. The cell is a mesenchymal stem cell, fibroblast, or a combination thereof. The cell-secreting factor is selected from the group consisting of growth factors, extracellular matrix, exosomes, thrombin, and secretory proteome.

7. The method for preparing the sustained-release hydrogel dressing as described in claim 6, wherein, In the steps of forming the hydrogel absorbent layer and the hydrogel dressing layer, the hydrogel dressing layer is first formed on an adhesive surface of the substrate layer, and then the hydrogel absorbent layer is formed on the hydrogel dressing layer.

8. A method for preparing a sustained-release hydrogel dressing as described in claim 7, wherein, The hydrogel dressing layer is formed by 3D printing of a hydrogel material containing the bioactive ingredients and under natural air-drying conditions, wherein the natural air-drying conditions include air-drying temperatures from room temperature to 37°C; the hydrogel absorbent layer is formed by freeze-drying another hydrogel material.

9. A method for preparing a sustained-release hydrogel dressing as described in claim 8, wherein, The steps of forming the hydrogel dressing layer include: pre-crosslinking a hydrogel matrix in the hydrogel material; printing the hydrogel material onto the bonding surface of the substrate layer by the 3D printing method; post-crosslinking the pre-crosslinked hydrogel matrix in the printed hydrogel material; and air-drying the hydrogel material naturally.

10. A method for preparing a sustained-release hydrogel dressing as described in claim 8, wherein, The steps of forming the hydrogel absorbent layer include: applying the other hydrogel material onto the hydrogel dressing layer; crosslinking a hydrogel matrix in the other hydrogel material; and freeze-drying the other hydrogel material.

11. A method for preparing a sustained-release hydrogel dressing as described in claim 10, wherein, The other hydrogel material can be applied by 3D printing, coating, or adhesive.

12. The method for preparing the sustained-release hydrogel dressing as described in claim 6 further includes: The hydrogel absorbent layer and the hydrogel dressing layer are transferred to a dressing carrier via the substrate layer; And a release liner is applied to the hydrogel absorbent layer.

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