THE COMPOSITION FOR INDUCING STEM CELLS TO INCREASE THEIR PROLIFERATION RATES AND / OR THEIR ACTIVITIES AND / OR THE EXPRESSION OF SELF-PROTECTION PROTEIN ANNEXIN A5 (Anxa5)

TWI942387BActive Publication Date: 2026-10-11ASIA XUANQI TECH TECHNOLOGY CO LTD
View PDF 2 Cites 0 Cited by

Patent Information

Application Number
TW114126644
Authority / Receiving Office
TW · TW
Patent Type
Patents
Current Assignee / Owner
Filing Date
2025-07-14
Publication Date
2026-10-11
Estimated Expiration
2045-07-13

Smart Images

  • Figure TWG2TB001915564_001
    Figure TWG2TB001915564_001
  • Figure TWG2TB001915564_002
    Figure TWG2TB001915564_002
  • Figure TWG2TB001915564_003
    Figure TWG2TB001915564_003
Patent Text Reader

Abstract

This invention discloses a composition for promoting the growth rate and / or enhancing the activity of stem cells and / or promoting the expression level of self-protective annexin A5, comprising adenine, a green tea polyphenol, and biotin. The concentrations of the adenine, the green tea polyphenol, and the biotin are 1-100 μM, 0.1-10 μM, and 0.5-50 μM, respectively.
Need to check novelty before this filing date? Find Prior Art

Claims

1. A composition that promotes the proliferation of skin mesenchymal stem cells and enhances their activity, comprising adenosine, green tea polyphenols, and biotin, wherein, The green tea polyphenol is selected from at least one of the group consisting of epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate; the concentration of adenosine is 1-100 µM; the concentration of the green tea polyphenol is 0.1-10 µM; the concentration of biotin is 0.5-50 µM; and the composition increases the proliferation rate of skin mesenchymal stem cells by at least 15%.

2. The composition as described in claim 1 may further comprise a carrier acceptable for pharmaceutical and / or skin-related products.

3. An in vitro method for promoting the proliferation of skin mesenchymal stem cells, comprising adding the composition as described in claim 1 to a cell culture medium to culture skin mesenchymal stem cells.

4. A composition for enhancing the expression of alkaline phosphatase in skin mesenchymal stem cells, comprising adenosine, green tea polyphenols, and biotin, wherein, The green tea polyphenol is selected from at least one of the group consisting of epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate; the concentration of adenosine is 20-100 µM; the concentration of the green tea polyphenol is 2-10 µM; the concentration of biotin is 0.5-20 µM; and the composition increases the alkaline phosphatase expression level of skin mesenchymal stem cells by at least 350%.

5. The composition as described in claim 4 may further comprise a pharmaceutical and / or other acceptable carrier.

Citation Information

Patent Citations

  • Serum-free culture medium for human mesenchymal stem cells

    CN117511861A

  • Use of epicatechin and derivatives and salts thereof for cardiac protection of ischemic myocardium and to ameliorate adverse cardiac remodeling

    US20110021466A1