Nanoprobe and uses thereof

Abstract

This article provides a nanoprobe comprising: a magnetic nanoparticle core and a coating layer. The coating layer encapsulates the magnetic nanoparticle core and comprises fucoidan or a derivative thereof, gelatin or a derivative thereof, and cationic macromolecules. This article also provides applications of this nanoprobe.

Claims

1. A nanoprobe comprising: a magnetic nanoparticle (MNP) core; and a coating layer covering the magnetic nanoparticle core, the coating layer comprising: fucoidan or a derivative thereof; gelatin or a derivative thereof; and a cationic macromolecule.

2. The nanoprobe of claim 1, wherein the cationic macromolecule is selected from the group consisting of cationic polysaccharides, cationic polypeptides, and cationic proteins.

3. The nano probe as requested in claim 2, wherein the cationic macromolecule is protamine.

4. The nano probe of claim 1, wherein the weight ratio of the magnetic nanoparticles: the fucoidan or its derivatives: the gelatin or its derivatives: the cationic macromolecule is about 0-3:0.5-3:0-5:0.1-2.

5. The nano probe of claim 4, wherein the weight ratio of the magnetic nanoparticles: the fucoidan or its derivatives: the gelatin or its derivatives: the cationic macromolecule is about 1.35:0.8:1.6:0.

6.

6. The nano probe in request item 1 is a magnetic resonance imaging agent for thrombi.

7. Use of a nanoprobe as claimed in any one of claims 1 to 5 in the preparation of a contrast agent for magnetic resonance imaging.

8. Use of a nanoprobe as claimed in any one of claims 1 to 5 in the preparation of a pharmaceutical product for the detection or diagnosis of thrombosis-related diseases.

9. As requested in item 7, it is used to detect or diagnose the age and / or composition of thrombi.

10. As claimed in claim 8, wherein the thrombosis-related diseases include stroke, deep vein thrombosis, pulmonary embolism, and coronary thrombosis.

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