MONOCLONAL ANTIBODIES THAT ARE UNISPECIFIC AND BIND ANTI-HUMAN PD-1

Abstract

The study refers to the selection of anti-PD-1 antibodies capable of binding to both cytomolgus PD-1 and human PD-1: PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-1 mAb 11, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14 or PD-1 mAb 15, and their human analogues. The invention relates to PD-1-binding molecules, including PD-1-binding fragments of anti-PD-1 antibodies, immune conjugates, and to double-specific molecules, including double-specific antibodies, B-B ...