The endophytic strain XYLARIA SP. KET18 is biologically pure and capable of synthesizing antioxidant and cytotoxic compounds against cancer cells.

Abstract

The invention relates to an endophytic fungal strain XyỊtíria sp. K.OΊΊ8 with biologically active stem isolated from the stem of the purslane plant (Keỉeỉeeria evelyniana Mast) distributed in Lam Dong, Vietnam, possessing antioxidant properties (hydroxyl and DPPH) exceeding 78% at a concentration of 000 pg / mL; It exhibits cytotoxic activity against two cancer cell lines, A549 and MCF7 (ICsíi 18,843,1 ug / mL, 24tl±2.5pg / mL, respectively) and carries the DNA sequence ITS15b8S"lTS2 with a length of 530bp and is registered in GenBank (code PQ03 9693). Crude extracts of strain ICET18 were isolated, purified, and their chemical structures were determined. Five pure compounds (hydroxyl, DPPH, sphenoxide) and three compounds with cytotoxic activity against A549 and MCF7 were identified.